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Application of screwtree root extractive in the preparation of anti-HBV medicament

A technology of hepatitis B and mountain sesame, applied in the application field of preparing anti-hepatitis B drugs, can solve the problems of few pharmacodynamic studies, achieve the goal of alleviating liver tissue cell damage, stable and long-lasting effect, and reducing hepatitis B inflammation Effect

Inactive Publication Date: 2013-07-24
林兴
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the publicly reported studies on Sesame chinensis mainly focus on the separation and identification of its chemical components, while there are few studies on its pharmacodynamics, and no studies on anti-hepatitis B have been reported.

Method used

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  • Application of screwtree root extractive in the preparation of anti-HBV medicament
  • Application of screwtree root extractive in the preparation of anti-HBV medicament
  • Application of screwtree root extractive in the preparation of anti-HBV medicament

Examples

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experiment example

[0023] One, the preparation of mountain sesame extract

[0024] 1. Preparation of Sesame water extract:

[0025] Take 1000g of decoction pieces of sesame sesame, add 10 liters of water to extract twice, each time for 1.5h, combine the extracts, dry under reduced pressure and constant temperature at 60°C to obtain 268.9g water extract of sesame sesame.

[0026] 2. Preparation of Sesame Alcohol Extract:

[0027] Add 10 liters of 75% ethanol to soak 1000g of mountain sesame herbal medicine pieces for 30 minutes, reflux extraction for 2 hours for the first time, and recover ethanol; then use 8 liters of 75% ethanol for reflux extraction for 1.5 hours, recover ethanol, combine the two extracts, and reduce the temperature at 60°C. Press and dry at constant temperature to obtain 113.5 g of ethanol extract of sesame.

[0028] 3. Preparation of Sesame triterpenoids:

[0029] Take 1000g of wild sesame, add 60% ethanol to soak for 1h, reflux extraction, extract 8000ml for 2h for the f...

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Abstract

The invention discloses application of traditional Chinese medicine screwtree root extractives in the preparation of anti-HBV medicament. In the invention, the performance of screwtree root extractives like aqueous extractive, alcohol extractive, and triterpenoid in resisting hepatitis B is studied for the first time. According to results of in-vitro and in-vivo tests, the screwtree root extractives can significantly inhibit HBV, mitigate hepatitis B inflammation, alleviate damage to liver histocyte, and have stable and lasting drug effect and no rebound phenomenon; therefore, the screwtree root extractives are superior to Lamivudine, a western medicine commonly used in clinical practice, and have unique advantages in controlling hepatitis B. The screwtree root extractives provided in theinvention have a very good research and development prospect in the treatment of hepatitis B and can be used to prepare traditional Chinese medicine preparation of various dosage forms like tablets, particulate agents, mixtures, and the like for the treatment of hepatitis B.

Description

technical field [0001] The present invention relates to the use of the Chinese medicinal herb sage extract, in particular the use of the sage water extract, alcohol extract and triterpenoids as raw materials in the preparation of anti-hepatitis B medicines. Background technique [0002] Hepatitis B is a common infectious disease and frequently-occurring disease caused by infection with hepatitis B virus (Hepatitis B Virus, HBV), which can easily become chronic and even develop into liver cirrhosis and liver cancer. The complexity of the disease's onset and its chronic refractory nature, especially the severity of its development to liver cancer, have made it one of the focuses of the current medical community, especially medical staff in my country. Current research shows that the pathogenesis of hepatitis B is mainly related to low immunity, persistent virus infection and progressive liver cell damage, and some traditional Chinese medicine extracts can pay equal attention t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K36/185A61P1/16A61P31/20
Inventor 林兴何敏黄权芳廖明黄仁彬张士军
Owner 林兴
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