Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation

A technology of atorvastatin calcium and atorvastatin, which is applied in the direction of drug combination, liposome delivery, active ingredients of heterocyclic compounds, etc., and can solve the problems of single drug and inability to fully control mild to moderate hypertension

Inactive Publication Date: 2010-10-20
HAINAN MEILAN SMITH KLINE PHARMA
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many antihypertensive drugs on the market, but each has advantages and disadvantages. Most of them are single drugs, which cannot fully control mild to moderate essential hypertension.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation
  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation
  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The preparation prescription (1000) of embodiment 1 amlodipine atorvastatin calcium liposome tablet:

[0072] Amlodipine besylate (calculated as amlodipine) 5g

[0073] Atorvastatin calcium (calculated as atorvastatin) 10g

[0074] Soy Phosphatidylglycerol 20g

[0075] Sodium Glycocholate 4g

[0076] Cholesterol 8g

[0077] Starch 38g

[0078] Lactose 30g

[0079] Crospovidone 6g

[0080] Povidone K30 5g

[0081] Magnesium Stearate 1.5g

[0082] Preparation Process:

[0083] (1) Dissolve 20g of soybean phosphatidylglycerol, 4g of sodium glycocholate and 8g of cholesterol in 400ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0084] (2) Add phosphoric acid-disodium hydrogen phosphate buffer solution with a pH value of 6.0, shake and stir to completely hydrate the phospholipid membrane, emulsify at a high speed, and filter th...

Embodiment 2

[0089] The preparation prescription (1000) of embodiment 2 amlodipine atorvastatin calcium liposome tablet:

[0090]Amlodipine besylate (calculated as amlodipine) 5g

[0091] Atorvastatin calcium (calculated as atorvastatin) 80g

[0092] Soy Phosphatidylglycerol 120g

[0093] Sodium Glycocholate 30g

[0094] Cholesterol 40g

[0095] Microcrystalline Cellulose 55g

[0096] Lactose 76g

[0097] Low-substituted hydroxypropyl cellulose 25g

[0098] Hypromellose 4g

[0099] Magnesium Stearate 5g

[0100] Talc powder 15g

[0101] Preparation Process:

[0102] (1) Dissolve 120g of soybean phosphatidylglycerol, 30g of sodium glycocholate and 40g of cholesterol in 700ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0103] (2) Add phosphoric acid-disodium hydrogen phosphate buffer solution with a pH value of 6.0, shake and stir to complete...

Embodiment 3

[0109] The preparation prescription (1000) of embodiment 3 amlodipine atorvastatin calcium liposome capsules:

[0110] Amlodipine besylate (calculated as amlodipine) 10g

[0111] Atorvastatin calcium (calculated as atorvastatin) 10g

[0112] Soy Phosphatidylglycerol 150g

[0113] Sodium Glycocholate 30g

[0114] Cholesterol 50g

[0115] Starch 90g

[0116] Carboxymethyl Starch Sodium 15g

[0117] Povidone K30 10g

[0118] Magnesium Stearate 5g

[0119] Preparation Process:

[0120] (1) Dissolve 150g of soybean phosphatidylglycerol, 30g of sodium glycocholate and 50g of cholesterol in 800ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0121] (2) Add citric acid-sodium citrate buffer solution with a pH value of 6.0, shake and stir to completely hydrate the phospholipid membrane, emulsify at a high speed, and filter through a 0.45 μm...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation which is prepared from amlodipine besylate and atorvastatin calcium medicine compound liposome and other solid preparation auxiliary materials; and the amlodipine besylate and atorvastatin calcium medicine compound liposome is prepared from benzene sulfonic acid amlodipine, atorvastatin calcium, soybean phosphatidyl glycerin, kennedy acute-inflammation sodium and cholesterol. Compared with traditional preparation, the preparation greatly improves the stability and the bioavailability, and has the advantages of stable medicine delivery, small side effect and more significant curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical solid preparation, in particular to an amlodipine atorvastatin calcium pharmaceutical composition liposome solid preparation and a preparation method thereof, which belong to the technical field of medicine. Background technique [0002] With the development of society, people's living standards are getting higher and higher, and more and more people suffer from hypertension. However, hypertension itself is not terrible, and diagnosis and treatment are easy. Complications: In hypertensive patients, due to the continuous increase of arterial pressure, arteriolar sclerosis in the whole body is caused, which affects the blood supply of tissues and organs, causing various serious consequences and becoming a complication of hypertension. [0003] There are many antihypertensive drugs currently on the market, but each has advantages and disadvantages, and most of them are single drugs, which cannot fully control mild...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4422A61K31/40A61K9/127A61P9/12A61P9/10
Inventor 王明
Owner HAINAN MEILAN SMITH KLINE PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com