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Amlodipine besylate sustained-release capsules

A technology of amlodipine besylate and amlodipine besylate, which is applied in the new field of medicine, can solve life-threatening problems, and achieve the effects of convenient administration, stable blood drug concentration, and long action time

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Severe malignant hypertension is an emergency of clinical hypertension. Although it is not as dangerous as hypertensive encephalopathy, if it is not treated in time, it can often endanger life. According to statistics, the survival rate within one year is only 10-20%.

Method used

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  • Amlodipine besylate sustained-release capsules

Examples

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Effect test

specific Embodiment approach

[0047] Specific embodiments are as follows, but do not limit the present invention in any way.

Embodiment

[0049] (1) Preparation of pill core

[0050] Amlodipine Besylate 10g

[0051] Blank ball core 50g

[0052] 7% PVP solution (solvent is 90% ethanol) 30g

[0053] Talc powder 1.5g

[0054] Preparation Process:

[0055]Amlodipine besylate is passed through a 160 mesh sieve, the prescription amount is weighed, and poured into the lower hopper. Start the granulation coating machine, the air inlet pressure is 0.5bar, CYL (air inlet air pressure) 3bar, CAP1 (atomization pressure) 0.9bar, pour blank ball cores, granulate, feeding speed 4rpm, peristaltic pump 10%, Turn blue at 150rpm, and dry at 50°C. The granulation is finished, and the output is 65g.

[0056] (2) Eight kinds of specific prescriptions are as follows: (determine the type and quantity of sustained release agent)

[0057] Prescription A:

[0058] With pill core 500g

[0059] Ethylcellulose 2g

[0060] Stearic acid 5g

[0061] Diethyl phthalate 0.2g

[0062] Talc powder 10g

[0063] 95% ethanol 1000g

[0064...

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Abstract

The invention belongs to the novel technical field of medicament and relates to a novel dosage form of amlodipine besylate sustained release capsules used for treating high blood pressure, chronic stable angina and variant angina and composed of amlodipine besylate, sugar spheres, sustained release agent, plasticizer and antisticking agent between which the weight ratio is 10:100:(0-20):(0-20):(0-25). Ethanol is used to prepare slurry, and weight of the antisticking agent is 1% that of the ethanol. The preparation technique comprises steps of preparing medicament containing spheres by granule coater, after drying, coating sustained release coating layer, drying by blowing, packing in hard capsules, thus obtaining the Manidipine sustained release capsules. Each capsule contains Manidipine 10mg-100mg, preferably 20mg-60mg. The inventive Chinese traditional medicine is slowly released so as to maintain relatively stable blood concentration and longer action time, and has advantages of reducing side effect, more convenient administration etc.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of amlodipine besylate, a pharmaceutical preparation for treating hypertension, chronic stable angina pectoris and variant angina pectoris and a preparation method thereof, specifically a benzene amlodipine besylate A preparation method and application of amlodipine sulfonate sustained-release capsules. Background technique [0002] Hypertension has become the number one killer of human health in most countries in the world, involving more than 20% of adults. According to statistics, there are 43 million people in the United States suffering from high blood pressure, and the number of hypertensive patients in my country has reached 120 million, and the number is increasing at a rate of 3 million per year. Among them, the incidence rate of severe hypertension in essential hypertension is more than 1%, and it can occur in all age groups, but it is most common...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K9/52A61K47/12A61K47/14A61K47/32A61K47/34A61K47/38A61P9/10A61P9/12
Inventor 王翰斌
Owner BEIJING HOPE HUGE PHARM SCI
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