Control releasing venlafaxine hydrochloride tablet and its prepn
A technology of venlafaxine hydrochloride and controlled-release tablets, which is used in pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of patients with large side effects, fluctuations in blood drug concentration, and poor compliance.
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[0050] Example one
[0051] Venlafaxine hydrochloride controlled-release tablet preparation with a weight ratio of drug tablet core and semipermeable film coating of 1:0.035, wherein:
[0052] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 114 parts of microcrystalline cellulose, 4 parts of sodium chloride, 6 parts of povidone K30, and 1 part of magnesium stearate.
[0053] The composition of the semipermeable film coating is: 9 parts of cellulose acetate, 0.78 parts of diethyl phthalate and 0.22 parts of polyethylene glycol 1500.
[0054] The preparation method of the above-mentioned venlafaxine hydrochloride controlled-release tablet preparation includes the following steps:
[0055] (1) Preparation of the drug tablet core: take the proportion of venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30, mix well, add 95% ethanol solution to make a soft material, over 20 Mesh sieve granulation, drying at 50°C, siz...
Example Embodiment
[0059] Example two
[0060] Venlafaxine hydrochloride controlled-release tablet formulation with a weight ratio of drug tablet core and semipermeable film coating of 1:0.05, wherein:
[0061] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 120 parts of microcrystalline cellulose, 1 part of sodium chloride, 15 parts of povidone K30 and 0.1 part of magnesium stearate.
[0062] The composition of the semipermeable film coating is 6 parts of cellulose acetate, 0.9 part of diethyl phthalate and 0.1 part of polyethylene glycol 1500.
[0063] The preparation method of the above-mentioned venlafaxine hydrochloride controlled-release tablet preparation includes the following steps:
[0064] (1) Preparation of drug tablet core: take the proportion of venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30, mix them evenly, add 90% ethanol solution to make a soft material, over 20 Mesh sieve granulation, drying at 40°C, sizin...
Example Embodiment
[0068] Example three
[0069] Venlafaxine hydrochloride controlled-release tablet preparation with a weight ratio of drug tablet core and semipermeable film coating of 1:0.02, wherein:
[0070] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 100 parts of microcrystalline cellulose, 30 parts of sodium chloride, 1 part of povidone K30 and 10 parts of magnesium stearate.
[0071] The composition of the semipermeable film coating is: 12 parts of cellulose acetate, 0.6 parts of diethyl phthalate and 0.4 parts of polyethylene glycol 1500.
[0072] The preparation method of the above-mentioned venlafaxine hydrochloride controlled-release tablet preparation includes the following steps:
[0073] (1) Preparation of the drug tablet core: take the proportion of venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30, mix well, add 95% ethanol solution to make a soft material, over 20 Mesh sieve granulation, drying at 60℃, siz...
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