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A gel and gastrodin technology, applied in the field of chemical pharmaceuticals, can solve the problems of aggravating the mental burden of patients with neurological diseases, and achieve the effects of avoiding the first-pass effect, delaying release, and good patient compliance
Inactive Publication Date: 2007-10-17
KPC PHARM INC
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In addition, gastrodin is eliminated quickly in the body (after intravenous administration in rabbits, rats and dogs, the elimination half-life is only 10-77 minutes), and the blood drug concentration required for treatment is generally maintained by increa
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Embodiment 1
[0055] Drug formulation:
[0056] Gastrodin 15g
[0057] Carbomer 934 1g
[0058] 1mol / LNaOH to adjust the pH value to 6.5
[0059] Chlorobutanol 0.5g
[0060] Peppermint Oil 0.5ml
[0061] Purified water add water to 100g
[0062] Preparation method: Take Carbomer 934, add 50ml of purified water, stir to make it fully swell, adjust the pH to 6.5 with 1mol / L NaOH to obtain a gel, then add gastrodin, chlorobutanol and peppermint oil, and add water to 100g, stir well to obtain gastrodin nasal gel.
Embodiment 2
[0064] Drug formulation:
[0065] Gastrodin 40g
[0066] Sodium Carboxymethyl Cellulose 2g
[0067] borneol 0.2g
[0068] Thimerosal 0.01g
[0069] Add purified water to 100g
[0070] Preparation method: Take sodium carboxymethyl cellulose, add 50ml of purified water, stir to make it fully swell to obtain a gel, then add gastrodin, thimerosal and borneol, add water to 100g, stir well to obtain gastrodin nasal gel agent.
Embodiment 3
[0072] Drug formulation:
[0073] Gastrodin 10g
[0074] Deacetylated Gellan Gum 0.5g
[0075] Ethylparaben 0.03g
[0076] Add purified water to 100ml
[0077] Preparation method: remove acetylated gellan gum, add 80ml of purified water, dissolve at 90°C and let cool to room temperature, then add gastrodin and ethylparaben to dissolve, filter the solution through a vertical fusing glass funnel, add water to 100ml, stir well to get gastrodin ion-sensitive nasal in-situ gel.
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Abstract
The invention relates to a gastrodin gel administrating by nasal cavity, which is composed of main medicine gastrodin and proper watercraft gel matrix and other additive medicine. The inventive gel can be adhered on the mucous membrane surface and extend the resorting period in the nasal cavity after administration. The released medicine can not only be absorbed into the blood circulation from mucous membrane, but also into the brain from the olfactory system, bypassing the blood-brain barrier to better do a treatment as gastrodin. The invention provides a new gastrodin without mucous membrane cilia toxicity has a high bioavailability, a strong patent compliance, a good stability and a simple production process and can be used for the treatments such as headache, blackout, neurasthenia and etc.
Description
technical field [0001] The invention relates to the technical field of chemical pharmacy, in particular to gastrodin nasal cavity gel. Background technique [0002] The competition in modern society is increasingly fierce, the pace of life is accelerated, mental pressure is increased, insomnia, dizziness, headache, etc. often plague people's work and life, and there is currently no effective treatment for this kind of disease, so it can improve symptoms and have little side effects , and easy to take drugs are welcomed by the majority of patients. [0003] Gastrodin is the main active ingredient of Gastrodia elata, a precious traditional Chinese medicine. Its chemical name is 4-hydroxyphenyl-β-D-glucopyranoside. It has various pharmacological effects such as sedation, analgesia, dilation of blood vessels, and improvement of blood rheology, and has low toxicity. , less adverse reactions. At present, gastrodin has been widely used clinically to treat vertigo (Ménière's disea...
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