Compound contraceptive composition, contraceptive transdermal patch containing composition and preparation method

A technology of a composition and a transdermal penetration enhancer, which is applied in the field of contraceptive transdermal patches and its preparation, can solve the problems of no drug delivery system, poor compliance of users, and high contraceptive failure rate, so as to avoid the first-pass effect, High bioavailability, effect of reducing frequency of dosing
CN101700246AInactive Publication Date: 2010-05-05SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Publication Date
2010-05-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a compound contraceptive composition, a contraceptive transdermal patch containing the composition and a preparation method. The compound contraceptive composition comprises effective contraceptive quantity of active components dispersed in a skeleton polymer substrate: etonogestrel and estrogen with a contraceptive cooperative function. Drugs are carried out bidirectional regulation by distribution and dispersal in two phases of the skeleton polymer substrate and a pressure sensitive adhesive substrate for drug transdermal release; and a crystallization inhibiting agent is added to a drug warehouse or the pressure sensitive adhesive substrate in order to effectively inhibit the drugs from crystallizing and maintain the long-time continuous transdermal high activity and power of the drugs in the substrates. The contraceptive transdermal patch prepared from the compound contraceptive composition maintains longer (1 to 7 days) stable drug release and blood drug concentration, has better effect, reduces administration frequency, adds user compliance and has obvious advantages in medical application.
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Description

technical field

[0001] The invention relates to a contraceptive transdermal patch with etonogestrel and its composition as active substances and a preparation method thereof. Background technique

[0002] The third-generation progestogens, such as desogestrel, gestodene and norethisterone, have strong physiological activity. At present, third-generation progestogens have been widely used in the world either alone or in combination with estrogen. Among them, desogestrel is metabolized into physiologically active etonogestrel (3-ketone-desogestrel) in the body through oral administration. The composition of desogestrel and estrogen is administered orally once a day, and there are many cases of missed doses, and the compliance of users is poor, so the contraceptive failure rate is high; at the same time, due to oral administration of desogestrel, it cannot Complete metabolic conversion to etonogestrel, therefore its bioavailability is low.

[0003] Chinese patent CN1190351A ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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