Preparations containing rosuvastatin calcium and amlodipine and method for preparing the same

A technology of rosuvastatin calcium and amlodipine is applied to the preparation field containing rosuvastatin calcium and amlodipine and the preparation field thereof to achieve the effect of synergistic effect
CN101095680AInactive Publication Date: 2008-01-02SHANGHAI SINE PHARMA LAB
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI SINE PHARMA LAB
Publication Date
2008-01-02
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a medical compound, which comprises effective amount of rosuvastatin calcium and amlodipine, which is characterized in that said two material are combined together and they can reduce blood fat and blood pressure, and they are cooperative.
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Description

technical field

[0001] The invention relates to a medicine for treating hyperlipidemia, hypercholesterolemia and antihypertension and a preparation method thereof, in particular to a preparation containing rosuvastatin calcium and amlodipine and a preparation method thereof. Background technique

[0002] Rosuvastatin calcium is an HMG-CoA reductase inhibitor, which can be used to treat atherosclerosis, hyperlipidemia, familial hypercholesterolemia and similar diseases. The molecular formula of rosuvastatin calcium is as follows:

[0003]

[0004] Rosuvastatin calcium is a calcium salt formed by basification of a single enantiomer (3R, 5S) carboxylic acid. The dihydroxyheptenoic acid part of the molecule is the common pharmacophore of statins, and the rest is different from other The presence of a polar methanesulfonyl amino group makes it relatively less lipophilic. The hydrophilicity of rosuvastatin calcium means that its passive diffusion ability is low, so it is diff...

Claims

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