Levamlodipine beaylate tablets and preparation method thereof

Abstract

The invention belongs to the technical field of medicament, and provides levamlodipine beaylate tablets and a preparation method thereof. The tablets consist of tablet cores using the levamlodipine beaylate as an active component and film coatings coated on the outer layer, wherein diluent in the tablet cores contains diatomite or aerosil, or a mixture of diatomite and aerosil, and contains other pharmaceutically acceptable supplementary materials; and the outer film coating accounts for 8 to 12 percent of the weight of the tablets, and can play a role in resisting humidity and avoiding light to ensure that the medicinal stability can be greatly improved, and related substances are obviously reduced. Furthermore, the tablets have small specification, so the tablets ensure uniform content, and improve dissolution; and the method is simple and controllable, and ensures that the hygroscopicity of the medicament is obviously reduced.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a tablet of levamlodipine besylate and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the major diseases that endanger human health in the world. In China alone, millions of people die of cardiovascular disease every year. According to the latest medical data, the incidence of cardiovascular disease is increasing year by year, and Patients are younger. Cardiovascular disease has the characteristics of high morbidity, high mortality, high disability rate, and high recurrence rate. People pay more and more attention to the treatment of cardiovascular disease, and its drug market potential is huge. Hypertension is one of the most common cardiovascular diseases in the world today and the leading cause of death and disability in adults. Due to the improvement of people's living standards and increasingly tense job com...

AI Technical Summary

Problems solved by technology

[0008] These patent documents make levamlodipine besylate into dripping pills and ordinary tablets respectively, which improves the dissolution rate of the main drug to a certain extent, but the drug specification is small, and has strong hygroscopicity and instability. The stability of adopting common tablet medicine can not be guaranteed, and dripping pill technology also is difficult to make preparation reach uniform, stable requirement really, in a word each patent document all can not overcome the shortcoming of levamlodipine besylate fully

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