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Starch hollow capsule and preparation method thereof

A hollow capsule and starch technology, which is applied in the fields of medicine and health care and health care products, can solve the problems of high price, fragility and high cost of capsules, and achieve the effects of good promotion prospects, good quality and low price.

Active Publication Date: 2013-05-01
北京爱特康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents 200510013285.3, 02134750.6, 200510124563.2 and 200910261415.3 disclose starch capsule production methods, the starch used is ordinary starch or modified starch, resulting in insufficient capsule strength and fragile
The production method of starch capsule disclosed in Chinese patent 200610022606.0, the main component is cellulose, starch is only a small part, resulting in high capsule price
Chinese patents 200610069021.4 and 200610093987.1 disclose the production method of starch capsules. The starch used is pure amylose, which needs to be extracted from starch, resulting in high cost, no crosslinking, and insufficient strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation of cross-linked high-amylose starch: dissolve 90 grams of mung bean starch in 360 ml of water, stir the emulsion evenly, add 0.2% of the weight of the starch composite cross-linking agent, adjust the pH to 10 with 10% NaOH, and heat to Stir and react at 50°C for 1 hour. After the reaction is completed, cool to room temperature, filter, wash with water, dry, and pulverize to obtain cross-linked high amylose starch.

[0026] The composite crosslinking agent is composed of sodium hexametaphosphate and adipic acid, and its weight ratio is 30 parts of sodium hexametaphosphate and 50 parts of adipic acid.

[0027] 2. Preparation of starch hollow capsules: Dissolve 70 grams of the above-prepared cross-linked high straight-linked starch in 1330 ml of water, stir evenly to form an emulsion, heat at 50°C for 15 minutes and then add 4 grams of tributyl citrate according to the formula ratio, 6 grams of guar gum, 2 grams of Span-80, and 2 grams of inulin, mixed thoro...

Embodiment 2

[0029] 1. Preparation of cross-linked high-amylose starch: dissolve 80 grams of pea starch in 320 ml of water, stir the emulsion evenly, add 0.5% of the weight of the starch as a composite cross-linking agent, adjust the pH to 11 with 10% NaOH, and heat to Stir and react at 60°C for 3 hours. After the reaction is completed, cool to room temperature, filter, wash with water, dry, and pulverize to obtain cross-linked high amylose starch.

[0030] The composite crosslinking agent is composed of sodium hexametaphosphate and adipic acid, and its weight ratio is 50 parts of sodium hexametaphosphate and 30 parts of adipic acid.

[0031] 2. Preparation of starch hollow capsules: Dissolve 80 grams of the above-prepared cross-linked high straight-linked starch in 453 ml of water, stir evenly to form an emulsion, heat at 55°C for 10 minutes and then add 10 grams of tributyl citrate according to the formula ratio, 10 grams of guar gum, 4 grams of Span-80, and 4 grams of inulin, mixed well...

Embodiment 3

[0033] 1. Preparation of cross-linked high-amylose starch: Dissolve 140 grams of mung bean starch in 560 ml of water, stir the emulsion evenly, add 0.4% of the weight of the starch as a composite cross-linking agent, adjust the pH to 10.5 with 10% NaOH, and heat to Stir and react at 40°C for 2.5 hours. After the reaction is completed, cool to room temperature, filter, wash with water, dry, and pulverize to obtain cross-linked high-amylose starch.

[0034] The composite crosslinking agent is composed of sodium hexametaphosphate and adipic acid, and its weight ratio is 40 parts of sodium hexametaphosphate and 40 parts of adipic acid.

[0035] 2. Preparation of starch hollow capsules: Dissolve 75 grams of the cross-linked high straight-linked starch prepared above in 502 ml of water, stir evenly to form an emulsion, heat at 53°C for 20 minutes and then add 7 grams of tributyl citrate according to the formula ratio, 8 grams of guar gum, 3 grams of Span-80, and 3 grams of inulin, m...

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PUM

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Abstract

The invention provides a starch hollow capsule and a preparation method thereof. The starch hollow capsule comprises components in parts by weight as follows: 60 parts to 90 parts of cross-linking high amylose, 3 parts to 15 parts of tributyl citrate, 5 parts to 15 parts of guar gum, 1 part to 5 parts of span-80 and 1 part to 5 parts of inulin. The cross-linking high amylose is prepared by cross-linking natural high direct connection starch through a cross-linking agent consisting of sodium metaphosphate and adipic acid. The starch hollow capsule has the advantages that the price is low, the quality is good, and the strength is high, standards of Chinese Pharmacopoeia are achieved, the friability is 5%, the disintegration time is five minutes, and obvious effects are achieved in practical application.

Description

technical field [0001] The invention relates to the technical field of medical hygiene and health care products, in particular to a starch hollow capsule formula and a preparation method thereof. Background technique [0002] The basic components of traditional capsule shells are gelatin, glycerin and water. Gelatin is produced by hydrolyzing the bones and skins of animals and plants. In view of the fact that gelatin capsules are easy to lose water and harden, absorb water and soften, and are prone to cross-linking and curing reactions when encountering aldehydes, solid traditional capsules should not be filled because they are easy to absorb moisture, weather, and occur with capsule materials. content of the reaction. In recent years, with the successive outbreaks of infectious diseases of animal origin all over the world, the international community has become more and more concerned about the safety of animal products. Recently, the detection of gelatin capsules in my co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 王美岭郝卫国程乐松
Owner 北京爱特康医疗科技有限公司
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