Uncaria slow-release pill preparation and preparation method thereof

A technique for sustained-release dropping pills and Uncaria chinensis, which is applied in the field of sustained-release dropping pills preparations and preparation fields of Uncaria chinensis, and can solve the problems of lack of sustained-release effect, inability to control blood pressure stably, unfavorable storage and the like.

Inactive Publication Date: 2010-11-17
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, total alkaloids of Uncaria can be used to treat hypertension, but the more common decoctions are not only not conducive to storage, carrying and taking, but also lack of slow-release effect, and cannot control blood pressure stably, so the long-term effect is not good

Method used

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  • Uncaria slow-release pill preparation and preparation method thereof
  • Uncaria slow-release pill preparation and preparation method thereof
  • Uncaria slow-release pill preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Weigh 20g of matrix PEG400020g, PEG1000015g, and 30g of stearic acid; place in a heating container and heat to 80°C and stir to melt, add 15g of rhynchophylline or total alkaloids of rhynchophyllum, fully stir, Drop the molten or mixed liquid medicine into the condensation column filled with 150# simethicone oil. The temperature of the liquid at the top of the condensation column is 30°C to 45°C, and the temperature of the liquid at the bottom is -2°C to 2°C. Take it out after molding to get Uncaria sustained-release dropping pills. The obtained product has a 2-hour cumulative release percentage of 37%-63%, a 6-hour cumulative release percentage of 64%-85%, a 10-hour cumulative release percentage of 82%-93%, and a 12-hour cumulative release percentage of 95%-100%. , better release rate, qualified dissolution time limit, better roundness.

Embodiment 2

[0076]Example 2: Weigh 20g of matrix PEG400020g, 10g of PEG10000, 17g of stearic acid, and 13g of glyceryl monostearate, place in a heating container and heat to 70°C and stir to melt, add rhynchophylline or total alkaloids of rhynchophyllum 20g, fully stirred, and under the condition of heat preservation, drop the molten or mixed liquid medicine into the condensation column filled with liquid paraffin. 5°C. Take it out after molding to get Uncaria sustained-release dropping pills. The obtained product has a cumulative release percentage of 35% to 57% in 2 hours, a cumulative release percentage of 55% to 73% in 6 hours, a cumulative release percentage of 80% to 91% in 10 hours, and a cumulative release percentage of 92% to 100% in 12 hours. , better release rate, qualified dissolution time limit, better roundness.

Embodiment 3

[0077] Example 3: Weigh 25g of matrix PEG4000, 15g of PEG6000, 10g of polyoxyethylene monostearate, 20g of stearic acid, place in a heating vessel and heat to 45°C-55°C and stir to melt, add rhynchophylline or 40g of vine total alkaloids, fully stirred, under the condition of heat preservation, drop the molten or mixed liquid medicine into the condensation column filled with 150# dimethyl silicone oil, the temperature of the liquid in the upper part of the condensation column is 50 ℃ ~ 60 ℃, and the liquid temperature in the bottom The temperature of the liquid is 4°C to 8°C. Take it out after molding to get Uncaria sustained-release dropping pills. The resulting product has a 2-hour cumulative release percentage of 65% to 77%, a 6-hour cumulative release percentage of 75% to 85%, a 10-hour cumulative release percentage of 80% to 97%, and a 12-hour cumulative release percentage of 92% to 100%. , better release rate, qualified dissolution time limit, better roundness.

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Abstract

The invention discloses an uncaria slow-release pill preparation and a preparation method thereof. The uncaria slow-release pill preparation is prepared from 10-40 parts by weight of uncarine or rhomotoxine and 50-90 parts by weight of substrates, wherein the substrates comprise 40-60 parts by weight of hydrophilic substrates and 10-30 parts by weight of hydrophobic substrates. In the invention, the uncaria slow-release pill preparation is slowly released by a slow-release technique so that the fluctuation of plasma drug concentration can be effectively reduced, the phenomenon of 'peak valley' generated from frequent administration of the common preparation can be avoided, the utilization rate of the drug is improved, and medical expenses can be reduced; the uncaria slow-release pill preparation reduces the direct stimulation of the drug to gastrointestinal tracts to reduce the generation of side effects of the drugs and be easier for patients to tolerate, is beneficial to long-term treatment and is more beneficial to the treatment of hypertension. In addition, the process is simplified so that the uncaria slow-release pill preparation process is easy to operate, the uncaria slow-release pill preparation is easy to carry and take, the problems existing in the prior art are solved and the purpose of the invention is achieved.

Description

technical field [0001] The invention relates to an uncaria sustained-release dropping pill preparation and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Hypertension refers to the increase of systemic arterial blood pressure, which is a common clinical syndrome. It can also be said that it is a systemic disease characterized by increased systolic and diastolic blood pressure, often accompanied by heart, brain, kidney and other organ functions or organic changes. Hypertension is a common disease and the most important risk factor for major diseases such as coronary heart disease and cerebrovascular disease that lead to human death. The morbidity and mortality of cardiovascular and cerebrovascular diseases are closely related to the blood pressure level of patients. Therefore, all countries in the world attach great importance to it. Prevention and research of hypertension. According to statistics from the national ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/20A61K47/34A61K47/42A61P9/12A61K47/10A61K47/14
Inventor 黄文荣周方勇李江
Owner GUIZHOU BAIHUA PHARMA
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