Use of the diabecron sustained-release tablet in treating the type 2 diabetes mellitus

Abstract

The invention discloses an application of metformin hydrochloride sustained-release tablets in the treatment of type 2 diabetes. The metformin hydrochloride sustained-release tablets are prepared from the following raw materials and adjuvants of (wt%): metformin hydrochloride 42-60, hydroxypropyl methylcellulose 34-50, sodium carboxymethyl cellulose 2-5, microcrystalline cellulose 1-3, and magnesium stearate 2-4. The tablets can be made by directly adding microcrystalline cellulose powder into granule, mixing and tabletting to reduce the dosage of the hydroxypropyl methylcellulose and the sodium carboxymethyl cellulose, resulting in a simple and convenient production method. The sustained-release tablets can effectively control and release drug at a certain speed, so as to reduce drug peak concentration in blood, reduce administration frequency and dosage, reduce adverse reactions, and be in favor of long-term treatment for patients with type 2 diabetes. The sustained-release tablets have hyperglycemia treating, hypoglycemia preventing, blood lipid reducing, and weight gain preventing effects.

Description

technical field [0001] The invention relates to a medicine for treating diabetes, in particular to the application of a metformin hydrochloride sustained-release tablet in the medicine for treating type 2 diabetes. Background technique [0002] In recent years, due to the improvement of people's living standards, diabetes has become the "third killer" that threatens human beings after cardiovascular diseases and tumors. At present, the number of diabetic patients in the world has exceeded 100 million, and the number of patients in my country has also exceeded 20 million. The most direct and effective way to treat diabetes is to inject insulin, but long-term use of insulin will make the body dependent on insulin and reduce the body's own metabolic function. Metformin, as a commonly used drug for the treatment of diabetes, is mainly aimed at type 2 diabetes. It is a kind of hypoglycemic drug that improves the glucose tolerance of patients with type 2 diabetes. It not only red...

AI Technical Summary

Problems solved by technology

Metformin hydrochloride is a highly water-soluble drug. Due to the short half-life in the body, in order to maintain the effective blood concentration, the dosage used in the treatment of diabetes is relatively large. The clinical oral ordinary tablet needs to be taken 2-3 times a day, 1-2 times each time. Tablets not only bring inconvenience to patients, but also have a high incidence of adverse reactions. For this reason, it is necessary to develop sustained-release drugs using metformin hydrochloride as the main raw material, especially to control the stable release at a certain rate within 24 hours. , maintain a stable therapeutic blood concentration to achieve a good therapeutic effect in the body, at the same time, reduce the number of medications, reduce the peak concentration of the blood drug to reduce the body's adverse reactions to the drug

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