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Medicine containing toad venom lipid-soluble substances and preparation method thereof

A technology of toad venom fat-soluble matter and toad venom, which is applied in the field of medicine, can solve the problems of high cost, poor safety, and side effects, and achieve the effects of reducing toxicity, improving stability, and reducing direct stimulation

Inactive Publication Date: 2015-12-09
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effectively reduce the toxicity and irritation of venom fat-soluble extract or its monomers, but venom lipid nanoparticle and lipid microsphere injection are both injection emulsions, which have relatively high requirements for excipients, and the inevitable existence of excipients in oil phase Sterols are easy to cause toxic and side effects, and have the disadvantages of high cost and poor safety

Method used

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  • Medicine containing toad venom lipid-soluble substances and preparation method thereof
  • Medicine containing toad venom lipid-soluble substances and preparation method thereof
  • Medicine containing toad venom lipid-soluble substances and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Extraction of Toad Sutra

[0060] Crush the toad venom medicinal material and pass through a 200-mesh sieve to obtain the fine powder of the toad venom medicinal material. Weigh the fine powder, add 5 times the amount of absolute ethanol, heat and reflux in a water bath at 60°C for 1 hour, let cool to room temperature, suction filter, and evaporate the filtrate to dryness , and the dried filtrate was dried in a vacuum oven (60° C.) for 24 hours to obtain the extract of toad venom.

Embodiment 2

[0062] Extraction of Toad Sutra

[0063] Crush the toad venom medicinal material and pass through a 200-mesh sieve to obtain the fine powder of the toad venom medicinal material. Weigh the fine powder, add 15 times the amount of absolute ethanol, heat and reflux in a water bath at 60°C for 1 hour, let cool to room temperature, suction filter, and evaporate the filtrate to dryness , and the dried filtrate was dried in a vacuum oven (60° C.) for 24 hours to obtain the extract of toad venom.

Embodiment 3

[0065] Extraction of Toad Sutra

[0066] Crush the toad venom medicinal material and pass through a 200-mesh sieve to obtain the fine powder of the toad venom medicinal material. Weigh the fine powder, add 10 times the amount of absolute ethanol, heat and reflux in a water bath at 60°C for 1 hour, let cool to room temperature, suction filter, and evaporate the filtrate to dryness , and the dried filtrate was dried in a vacuum oven (60° C.) for 24 hours to obtain the extract of toad venom.

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Abstract

The invention provides medicine containing toad venom lipid-soluble substances and a preparation method thereof. According to the toad venom lipid-soluble substances, the weight sum of bufalin, cinobufagin and resibufogenin is larger than 50% of the total weight of the toad venom lipid-soluble substances. The preparation method of the toad venom lipid-soluble substances includes the steps that toad venom herbs are smashed, then absolute ethyl alcohol is added, the amount of the absolute ethyl alcohol is 5-50 times that of the herbs, heating reflux is performed on the mixture for 1 h in a water bath of 60 DEG C, then the mixture is cooled to indoor temperature, suction filtration is performed, dry extract is obtained after filtrate is evaporated to dryness, purified water is added into the extract for ultrasonic suspending, the amount of the purified water is 5-30 times that of the extract, and extracting is performed through chloroform, wherein the amount of chloroform is 5-50 times that of the mixture. The invention further provides a medicine composite and a preparation method thereof. The medicine composite is a toad venom extract lipid microsphere oral solution and is used for treating gastrointestinal tumors.

Description

technical field [0001] The invention relates to the technical field of medicine, specifically, it relates to a method for extracting fat-soluble matter containing toad venom, and an oral solution of lipid microspheres thereof. Background technique [0002] In recent years, cancer has gradually become the number one killer of human beings in the new century. According to the report of the World Health Organization (WHO), there are currently 24.6 million cancer patients worldwide; by 2020, it is estimated that it will reach 30 million. In 2005, 7.6 million people died of cancer, accounting for 13% of the world's 58 million population. By 2020, cancer will cause more than 10 million deaths every year. In 2005, the number of cancer deaths in China was nearly 1.9 million, of which 1.2 million lived below the age of 70. Experts predict that by 2020, the number of deaths from cancer will exceed 4 million. [0003] Cancer pain is the most common and difficult-to-control symptom o...

Claims

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Application Information

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IPC IPC(8): A61K35/65A61K9/16A61P35/00A61P29/00A61P39/00
Inventor 陶秀梅尚丽霞牟昳崔健
Owner NKD PHARMA CO LTD
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