Application, vaccine and preparation method of an avirulent strain toxoplasma and traditional Chinese medicine polysaccharide adjuvant composition

A technology without virus strain and toxoplasma, applied in the fields of tumor drugs, vaccines and preparation, can solve the problems of host harm, low immunity of cancer patients, treatment of patients with less toxoplasma, etc., and achieve a significant therapeutic effect.

Active Publication Date: 2020-07-14
SUN YAT SEN UNIV
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Problems solved by technology

However, due to the harm of wild-type Toxoplasma infection to the host, live Toxoplasma is not suitable for the treatment of tumor patients. In addition, cancer patients are often accompanied by low immunity and are more susceptible to Toxoplasma infection.

Method used

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  • Application, vaccine and preparation method of an avirulent strain toxoplasma and traditional Chinese medicine polysaccharide adjuvant composition
  • Application, vaccine and preparation method of an avirulent strain toxoplasma and traditional Chinese medicine polysaccharide adjuvant composition
  • Application, vaccine and preparation method of an avirulent strain toxoplasma and traditional Chinese medicine polysaccharide adjuvant composition

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Embodiment Construction

[0029] The use of an adjuvant composition of an avirulent strain Toxoplasma gondii and traditional Chinese medicine polysaccharides, the composition is used in the treatment of tumors and the preparation of drugs for the treatment of tumors. The traditional Chinese medicine polysaccharide has curative effect, and the polysaccharide of the traditional Chinese medicine of the present invention adopts one, any two or a mixture of more than two of lentinan, astragalus polysaccharide, ginseng polysaccharide and ganoderma polysaccharide.

[0030] Traditional Chinese medicine polysaccharide adjuvants can cooperate with the immune activation of Toxoplasma through immune synergy, and effectively activate some specific anti-tumor immune regulatory pathways at multiple targets, especially the anti-tumor immune pathways related to immune activation of killer T cells. The experiment of intraperitoneal injection of mice proves that it has a certain therapeutic effect on bladder cancer, brain...

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Abstract

The invention discloses application of a composition of an avirulent toxoplasma strain and a traditional Chinese medicine polysaccharide adjuvant, and a vaccine and a preparation method thereof. The traditional Chinese medicine polysaccharide adjuvant can be cooperated with the immune activation effect of toxoplasma via immune synergism for multi-target high-efficiency activation of certain specific anti-tumor immunoregulation pathways, especially anti-tumor immunoregulation pathways related to immune activation of cytotoxic T-cells. The composition can be used for treating tumors and preparing biological drugs used for treating tumors, especially for treatment of gastrointestinal tumors; and in particular, the composition has substantial treatment effect on bile duct carcinoma.

Description

technical field [0001] The invention relates to the field of tumor biotherapy, in particular to a tumor drug, a vaccine and a preparation method. Background technique [0002] Digestive tract tumors including cholangiocarcinoma (including gastric cancer, colorectal cancer, hepatobiliary and pancreatic cancer, etc.) are multiple cancers in my country, which seriously threaten people's health. Cholangiocarcinoma is a highly malignant tumor originating from the epithelium of the biliary tract. The incidence of cholangiocarcinoma accounts for 3% of malignant tumors of the digestive tract. Its morbidity and mortality have continued to increase globally in recent years. Incidence rates are also rising rapidly. The hyperplastic nature of cholangiocarcinoma is characterized by extremely rich tumor microvessels and strong heterogeneity of tumor genes, which makes it difficult to treat with adjuvant therapies such as chemotherapy and radiotherapy. Currently, radical tumor resection ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K39/00A61P35/00
CPCA61K39/0011A61K39/39A61K2039/55583A61K2039/572A61K2039/585
Inventor 周兴旺廖婉琴杨兆收
Owner SUN YAT SEN UNIV
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