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The Sterne strain is avirulent, meaning its ability to cause illness in people or animals have been reduced. This is because the Sterne strain has lost its ability to produce a capsule, or a layer of polysaccharides, which protects it from being consumed and destroyed by our defensive immune system cells.
Avirulent live bacterial vaccines cured of plasmids containing antimicrobial resistance genes
PendingUS20260097106A1Antibody medical ingredientsVector-based foreign material introductionMicroorganismImmunogenicity
A vaccine comprising a live avirulent strain of bacteria or an immunogenic composition that comprises a live avirulent strain of bacteria, wherein the bacteria is cured of plasmids and / or transposons that contain AMR genes, and a non-conjugative synthetic curing plasmid that cures plasmids and / or transposons that contain AMR genes from such bacteria. A method for producing the live avirulent strain of bacteria or an immunogenic composition that comprises a live avirulent strain of bacteria; a method for treating, preventing, or reducing the severity, duration, or incidence of clinical signs, of a virulent bacterial infection; and a method for preventing, or reducing the risk or incidence of transference of AMR genes are also disclosed.
Owner:DRS KOEHNK & FELDMAN LLP