19 results about "Gastrointestinal tissue" patented technology

This invention relates to a method for detecting colorectal cancer tumor cell-associated microorganisms, specifically a method for eliminating intestinal fecal microbial contamination and detecting colorectal cancer tumor-associated microorganisms, belonging to the field of biotechnology. This invention initially eliminates fecal microbial contamination from the sample structure by coarsely shearing and enzymatically digesting the intestinal folds and villi; then, it uses a 40μm cell sieve to filter out incompletely digested tissue fragments, further eliminating intestinal fecal bacteria contamination, and collecting a single-cell suspension; subsequently, the collected single-cell suspension is repeatedly washed with 300g centrifugation to remove as many intercellular or loosely bound "transient bacteria" as possible, retaining intracellular and firmly colonized microorganisms. Ultimately, this eliminates the severe contamination from the large and complex fecal microorganisms, allowing the detection of tumor cell-associated microorganisms, which are already present in low biomass. This method is suitable for detecting microorganisms in gastrointestinal tissues that are in direct contact with the environment.

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

The application provides a kind of based on digestive tract tissue protein expression abundance determination method and system, applied to digestive tract tissue image processing technical field. Including: based on the PVDF membrane image after color development of digestive tract tissue acquisition in vitro, contain at least one protein standard band and the protein band of multiple target proteins;When determining the presence of electrophoresis distortion according to the band of target protein standard, construct pixel space coordinate system;The target image is obtained by angle correction and linear repair to PVDF membrane image, and the protein band corresponding to multiple target proteins in target image is in horizontal alignment state under pixel space coordinate system;Determine the development area of each target protein in target image and the irregular region of interest wrapped the protein band corresponding to multiple target proteins, and for each target protein, the expression abundance of target protein is obtained by analyzing the development area and the irregular region of interest, and the accuracy of the protein expression abundance is higher.

The anchoring method of the gastrointestinal tract inner sleeve comprises the steps that the gastrointestinal tract sleeve is arranged outside the anchoring device in a sleeving mode, so that the anchoring holes are aligned with the negative pressure holes one by one; when the gastrointestinal tract sleeve is conveyed to a pre-anchoring position in the gastrointestinal tract, the negative pressure source is started, gastrointestinal tract tissues are adsorbed into the negative pressure holes in the negative pressure cylinder through the anchoring holes in the gastrointestinal tract sleeve under the action of negative pressure, and when the gas pressure in the negative pressure cylinder is reduced to a certain threshold value, the normally-closed constant pressure valve is opened, so that the gastrointestinal tract sleeve is anchored in the gastrointestinal tract. The gas in the cylindrical needle pushing part flows into the negative pressure cylinder, and the cylindrical needle pushing part slides in the axial direction of the negative pressure cylinder to push the mechanical latch to puncture and be adsorbed into gastrointestinal tract tissues, so that the anchoring of the gastrointestinal tract sleeve is realized, the anchoring operation of a plurality of anchoring points of the gastrointestinal tract sleeve can be completed at one time, and the anchoring efficiency of the gastrointestinal tract sleeve is improved. One-by-one adsorption and puncture are avoided, and the method is efficient and convenient.

To provide a novel gastrointestinal tissue recovery promoter. [Solution] A gastrointestinal tissue recovery promoter containing β-hydroxybutyric acid as an active ingredient, for promoting the recovery of gastrointestinal tissue. [Effects] By including β-hydroxybutyric acid at a predetermined concentration as an active ingredient, it can promote the recovery of gastrointestinal tissue, thus making it a convenient gastrointestinal tissue recovery promoter.

Avian coccidiosis is a disease caused by an intracellular parasitic protozoan of the genus Eimeria, which induces lesions in the gastrointestinal tissues of birds due to its replication. The process of qualifying an oocyst is almost entirely manual, using, in particular, the optical microscope counting technique, in which each identified object must be classified as sporulated or non-sporulated, stained or unstained. For the identification process, the method used is PCR (polymerase chain reaction), in which the presence of each species is detected, but without identifying each oocyst. This manual process is time-consuming and susceptible to errors. The method proposed herein introduces a computer vision model, based on Artificial Intelligence, capable of automating this classification process. The model analyzes samples and provides quantitative results, including the classification of oocysts into the categories of sporulated, non-sporulated, stained, and unstained, as well as the identification of Eimeria species (acervulina, brunetti, maxima, mitis, necatrix, praecox, or tenella). This computational model is entirely based on machine learning and is capable of identifying the presence of oocysts in a sample (image), classifying each identified oocyst into categories such as sporulated or non-sporulated, stained or unstained, quantifying the objects in each category, and identifying the Eimeria species.

The invention discloses a pharmaceutical composition of a pentacyclic triterpenoid and capecitabine and application of the pharmaceutical composition, and belongs to the technical field of biological medicines. By reducing the hydrolysis of capecitabine in gastrointestinal tracts and livers, the pharmaceutical composition not only slows down the early release of capecitabine drug bodies in gastrointestinal tracts and livers, increases the total bioavailability of the drug bodies and 5-fluorouracil, reduces the non-uniform high distribution of capecitabine in normal tissues such as gastrointestinal tissues, but also improves the bioavailability of capecitabine in gastrointestinal tracts and livers. Reducing toxicity in these tissues; meanwhile, the effectiveness of the medicine is improved by relatively increasing the medicine distribution of the targeted tumor part. The combination will be suitable for all tumor treatment, especially solid tumor treatment.

The invention relates to the technical field of surgical cutting devices, in particular to a gastrointestinal tissue electrosurgical cutting device for digestive surgery, which comprises a gun body, an operating rod is arranged on the gun body, a nail anvil, a nail box and a blade are arranged on the operating rod, and a driving motor and a battery for supplying energy to the driving motor are arranged in the gun body. The driving motor is used for driving the blade to move, a limiting groove is formed in the nail box, two expansion pieces used for expanding holes are arranged in the limiting groove, and auxiliary plates are fixedly installed on the expansion pieces. The expansion piece is provided with a straight part and a first elastic part, the first elastic part is fixedly connected with the straight part, and the first elastic part is bent outwards. According to the invention, the insertion performance of an existing electrosurgical cutting device through a tissue hole in a narrow operation space is improved, the operation difficulty is reduced, and the overall smoothness and safety of the operation are improved.

The invention relates to the technical field of medical instruments, in particular to an intestine and stomach lifting device for a laparoscope in the general surgery department, which comprises a clamping frame, a lifting support block is slidably connected to the clamping frame, a telescopic cylinder is fixedly connected to the bottom of the lifting support block, a locking assembly is arranged on the telescopic cylinder, and a clamping jaw assembly is arranged at the bottom end of the telescopic cylinder; the clamping jaw assembly comprises a clamping seat and a plurality of finger branches, the finger branches are elastic colloidal silica bodies, a plurality of air chambers and interlayers are arranged in the finger branches, a plurality of negative pressure pipes are arranged on the finger branches, and an air pump assembly is arranged at the bottom of the lifting supporting block; a button assembly is arranged on the surface of the telescopic cylinder piece and is in signal connection with the controller. The flexible clamping jaw made of the elastic silica gel material is adsorbed on the contact surface of the clamping jaw and the gastrointestinal tissues in combination with negative pressure, so that flexible adaptation and dynamic stable lifting of the gastrointestinal tissues with different anatomical sizes are realized, and the problems of size mismatching and tissue damage caused by immobilization parameter design are solved.

The application provides a mass spectrum processing method and system based on digestive tract tissues, and is applied to the technical field of mass spectrum data processing. By acquiring mass spectrum of each digestive tract tissue; the retention time and mass-to-charge ratio information of each main peak in the mass spectrum are automatically extracted to obtain a core feature vector representing the protein abundance of the digestive tract tissue; and the protein identity information associated with the index of the core feature vector is determined; according to the core feature vector of the healthy digestive tract tissue, a first protein abundance is determined; and according to the core feature vector of each of the multiple diseased digestive tract tissues, multiple second protein abundances are determined; the fold change and the significant difference value are calculated according to the first protein abundance and the multiple second protein abundances; the target protein abundance corresponding to the fold change and the significant difference value satisfying the preset condition is determined; and according to the protein identity information corresponding to the target protein abundance, a protein differential quantification list is output. It has high credibility and data traceability.

The present application relates to the field of medical devices, in particular to a gastrointestinal lifting device for general surgery laparoscopy, comprising a non-invasive clamp and a puncture cannula, the non-invasive clamp is composed of a clamp head, a connecting rod and a handle operating end, the surface of the handle operating end is provided with an angle locking assembly for locking the opening and closing angle of the handle operating end; the top end of the puncture cannula is provided with a plurality of limiting holes, the surface of the connecting rod is provided with a sliding ring, the bottom of the sliding ring is fixedly connected with a plurality of limiting seats corresponding to the limiting holes; the inside of the sliding ring is provided with a sliding locking assembly; the surface of the connecting rod is provided with a fitting assembly. The clamp head clamping angle is stably locked by the angle locking assembly, avoiding hand fatigue caused by long-time hand holding operation of the operator; by the cooperation of the sliding ring, the limiting seat and the puncture cannula, the non-invasive clamp can be fixed on the puncture cannula as a whole, preventing the lifted gastrointestinal tissue from resetting, shifting or rebounding due to its own elasticity, abdominal pressure change or surgical disturbance, effectively maintaining the exposure state of the surgical field.

The utility model relates to medical supplies technical field, especially a kind of gastrointestinal postoperative nursing device, including abdominal belt, the front end middle part of abdominal belt is fixedly connected with nursing assembly, the left part and the right part of front end of abdominal belt are fixedly connected with connecting band, the front end of two connecting bands is fixedly connected with several silica gel balls, the left end of abdominal belt is fixedly connected with first fixed band, the right end of abdominal belt is fixedly connected with second fixed band, the outside of first fixed band and second fixed band is fixedly connected with elastic component, the outside of two elastic components is fixedly connected with fixed component with together.The utility model relates to a kind of gastrointestinal postoperative nursing device, the inflatable nursing pad in nursing assembly can be inflated according to patient's demand adjustment, the nursing pad after proper inflation can form accurate local compression to surgical site, play the effect of hemostasis, alleviate swelling, while providing buffer protection for fragile postoperative gastrointestinal tissue, avoid direct impact of external force.

The invention discloses a flurbiprofen axetil-containing pharmaceutical composition in the technical field of pharmaceutical preparations. The flurbiprofen axetil-containing pharmaceutical composition comprises flurbiprofen axetil and an intestinal carboxylesterase 2 inhibitor. The intestinal carboxylesterase 2 inhibitor can obviously inhibit intestinal carboxylesterase 2 from hydrolyzing flurbiprofen axetil to release flurbiprofen, so that the local concentration and accumulation of flurbiprofen in gastrointestinal tract tissues are obviously reduced, the damage of flurbiprofen to gastrointestinal mucosa is reduced, the bioavailability of flurbiprofen is improved, the effect is enhanced, the toxicity is reduced, and the preparation method is simple and convenient. The composition is suitable for inflammatory disease and pain management requiring long-term administration.

A gastrointestinal implant comprising a stent adapted to be positioned distal to a pyloric sphincter, within a superior duodenum of a patient, and having non-point spring elements for contacting an inner surface of the superior duodenum. A lumen of a flexible sleeve coupled to the stent receives food from the stomach and allows it to pass through the sleeve lumen without contacting gastrointestinal tissue adjacent to the sleeve. The stent may be sized to fit securely in the superior duodenum without proximal or distal migration.

The present application relates to the field of traditional Chinese medicine, and particularly relates to a composition for treating constipation and application thereof, wherein the composition is prepared from the following raw medicinal materials according to weight parts: perilla seed 8-12 parts, astragalus 12-18 parts, citrus aurantium 8-12 parts, allium 7-12 parts, cistanche 8-15 parts, bitter almond 12-20 parts, dried tangerine or orange peel 13-18 parts, and hemp seed 12-18 parts. The present application effectively solves the problems of the existing drug, i.e. polyethylene glycol as a world gastrointestinal tissue constipation guideline IA recommended drug, such as single action pathway, easy tolerance failure, and unsatisfactory Bristol V-VII type STC efficacy, and other limitations, and has important theoretical value and clinical conversion prospect for promoting modernization of traditional Chinese medicine.

An electrode therapy device (300, 600, 700, 800, 900, 902, 1000, 1100, 1200, 1300, 1400, 1400', 1400a, 1400b, 1400c, 1600, 1600', 1800, 1900, 2000, 2100, 2200, 2300, 2400) for treating gastrointestinal tissue or other tissues includes an actuable electrode deployment system (310, 610, 710, 810, 910, 912, 1010, 1110, 1210, 1310, 1410, 1410', 1410a, 1410b, 1410c, 1610, 1610', 1810, 1910, 2010, 2110, 2210, 2310, 2410), the actuable electrode deployment system (310, 610, 710, 810, 910, 912, 1010, 1110, 1210, 1310, 1410, 1410', 1410a, 1410b, 1410c, 1610, 1610', 1810, 1910, 2010, 2110, 2210, 2310, 2410) can be attached to the endoscope (320) and flexible electrodes (366, 666, 766, 1066, 1166, 1266, 1366, 1466, 2466), such as flexible printed circuit strips, can be moved from a collapsed configuration to a deployment configuration in situ with the tissue. When in the retracted configuration, the electrodes are at least partially coiled within the housing (1316, 1416, 1616, 2016, 2116), and the actuating elements (1314, 1414, 1414a, 1414b, 1414c, 1614) are mounted at the proximal end (1306) of the endoscope or anterior to the distal end (328) of the endoscope and at least partially located within the housing. Deployment of the electrodes can be automatically stopped or controlled based on a current drawn by the actuating elements, indicating the mechanical resistance encountered by the electrodes. The electrode treatment system may include shafts (370, 770, 870, 970, 972, 1370, 1470, 2470) that pass through the working channel (372) of the endoscope and are electrically and / or mechanically connected to a controller (14) and / or an actuating element at the proximal end.

The utility model discloses an endoscope alimentary canal treatment auxiliary part and a puncture stitching instrument assembly, and the endoscope alimentary canal treatment auxiliary part comprises a mounting seat and a resisting part. After entering a human body along with an endoscope, the endoscope alimentary canal treatment auxiliary piece penetrates through the through hole through the clamping piece to pull alimentary canal tissue to enable the alimentary canal tissue to be located on the resisting part, and then other structures are matched with the resisting part to extrude the alimentary canal tissue and prepare before puncture of a stitching instrument. Then the digestive tract tissue is punctured and sutured by the suturing instrument; the auxiliary part for endoscopic digestive tract treatment can be provided with multiple through holes, and an ultrasonic endoscope is used for scanning pulled tissues and external conditions of a digestive tract lumen before puncture, so that the condition that visceral organs and large vessels are damaged in the puncture process is avoided, and the safety is improved. Besides, the auxiliary part for endoscopic digestive tract treatment is simple in structure, and meanwhile, the problems of effective puncture of a stitching instrument and turning of a stitching needle are effectively solved through matching of other structures and the stopping part.

The invention relates to a preoperative simulation and evaluation method for gastrointestinal system reconstruction, which comprises the following steps of: acquiring multi-source preoperative clinical data, identifying stress and strain response trajectories formed in a lesion process of gastrointestinal tissues, and calibrating a structural response lag region in the gastrointestinal tissues so as to determine an adjustable tissue boundary range; synthesizing tissue deformation adaptability, anatomical continuity and adjacent organ space constraint conditions, and screening a plurality of anatomical pathways as reconstruction candidate paths; evaluating the stress concentration trend of the anastomotic stoma and the peripheral area in the postoperative stage based on the candidate paths in combination with the operation parameters of a traction angle, suture displacement and tension transfer generated in the operation, identifying the area with potential structural fatigue or deformation accumulation risk, and establishing strain adaptability indexes corresponding to the paths; by analyzing the pressure distribution pattern and the peristalsis direction of the gastrointestinal system of a patient, a pressure migration intersection point caused by structural adjustment is identified, and in combination with a path change trend, a potential fluid backflow, pressure accumulation or negative pressure interference risk area existing after anastomosis is judged.

The present invention relates to methods for regenerating gastrointestinal tissue (e.g., esophageal tissue) and synthetic scaffolds.