Oxaliplatin chitosan nanoparticle and application thereof

A technology of chitosan nanoparticles and oxaliplatin is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, digestive system, etc., which can solve the problem of chitosan nanoparticles without oxaliplatin. and other problems, to achieve the effects of cheap raw materials, high encapsulation rate and simple process

Inactive Publication Date: 2013-06-26
HANGZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Oxaliplatin chitosan nanoparticle and application thereof

Examples

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Effect test

Embodiment 1

[0019] Example 1 Oxaliplatin chitosan nanoparticles 1

[0020] 40 mg chitosan (molecular weight 1 x 10 4 ) was dissolved in 13 mL acetic acid aqueous solution (pH=4.0), weighed 5.7 mg sodium tripolyphosphate (TPP) was dissolved in 5 mL water, 10 mg oxaliplatin was dissolved in 2 mL water, and the TPP solution was mixed with oxaliplatin After the platinum solution was mixed, it was slowly added to the chitosan solution, and magnetically stirred at room temperature for 30 min to obtain a colloidal solution of chitosan nanoparticles. Using a tangential flow membrane bag (molecular weight 10K) for ultrafiltration, using water as a replacement liquid, repeating ultrafiltration, and adjusting the volume of the suspension to obtain oxaliplatin-chitosan nanoparticles. Its average particle size is 59 nm, and the encapsulation efficiency is 86.54%.

Embodiment 2

[0021] Embodiment 2 Oxaliplatin chitosan nanoparticles 2

[0022] 40 mg chitosan (molecular weight 1 x 10 4 ) was dissolved in 13 mL acetic acid aqueous solution (pH=4.0), 8 mg sodium tripolyphosphate (TPP) was weighed and dissolved in 5 mL water, 10 mg oxaliplatin was dissolved in 2 mL water, and TPP solution was mixed with oxaliplatin After the platinum solution was mixed, it was slowly added to the chitosan solution, and magnetically stirred at room temperature for 30 min to obtain a colloidal solution of chitosan nanoparticles. Dilute to 20 mL with water, perform ultrafiltration with a tangential flow membrane bag (molecular weight: 10K), use water as a replacement liquid, repeat ultrafiltration, and adjust the volume of the suspension to obtain oxaliplatin-chitosan nanoparticles. Its average particle size is 88nm, and the encapsulation efficiency is 82.13%.

Embodiment 3

[0023] Embodiment 3 Oxaliplatin chitosan nanoparticles 3

[0024] 40 mg chitosan (molecular weight 1 x 10 4 ) was dissolved in 13 mL acetic acid aqueous solution (pH=4.0), 13.3 mg sodium tripolyphosphate (TPP) was weighed and dissolved in 5 mL water, 10 mg oxaliplatin was dissolved in 2 mL water, and TPP solution was mixed with oxaliplatin After the platinum solution was mixed, it was slowly added to the chitosan solution, and magnetically stirred at room temperature for 30 min to obtain a colloidal solution of chitosan nanoparticles. Dilute to 20 mL with water, perform ultrafiltration with a tangential flow membrane bag (molecular weight: 10K), use water as a replacement liquid, repeat ultrafiltration, and adjust the volume of the suspension to obtain oxaliplatin-chitosan nanoparticles. Its average particle size is 116 nm, and the encapsulation efficiency is 83.37%.

[0025] The particle size figure of embodiment 4 experimental example 1 gained oxaliplatin chitosan nanopart...

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Abstract

The invention discloses an oxaliplatin chitosan nanoparticle and an application thereof. The preparation materials of the oxaliplatin chitosan nanoparticle comprise oxaliplatin, chitosan, sodium tripolyphosphate and an acetic acid aqueous solution. The oxaliplatin chitosan nanoparticle disclosed by the invention can be applied to preparing a drug for treating gastrointestinal tumors. Compared with the prior art, the oxaliplatin chitosan nanoparticle disclosed by the invention is small in grain size, high in encapsulation efficiency, low in material price and simpler in process.

Description

(1) Technical field [0001] The invention relates to the field of drug nanoparticles, in particular to an oxaliplatin-chitosan nanoparticle and an application thereof. (2) Background technology [0002] Oxaliplatin is a third-generation platinum-based anticancer drug. In 2004, the FDA approved oxaliplatin for injection in combination with 5-fluorouracil and folinic acid for the first-line treatment of advanced colorectal cancer. Oxaliplatin preparations currently on the market include water injection and freeze-dried powder injection. Oxaliplatin has a significant effect on advanced colorectal cancer, and can also treat other gastrointestinal tumors such as gastric cancer. However, with the extensive clinical application of oxaliplatin, its adverse reactions have been continuously discovered and reported. Neurotoxicity, gastrointestinal reactions, and bone marrow suppression are common adverse reactions. [0003] Nanoparticles are a kind of drug delivery system with good ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/282A61K31/194A61K47/36A61P35/00A61P1/00
Inventor 曾昭武王俊洁肖人钟谢恬王小丽周广林刘星言
Owner HANGZHOU NORMAL UNIVERSITY
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