40 results about "Concentration dependence" patented technology

A new method is presented for measuring the molecular properties of an unfractionated solution of macromolecules. Sample aliquots spanning a range of concentrations are injected sequentially into a stream of solution and flow towards the detectors. Each aliquot produces, thereby, an effective “peak” whose elements correspond to different concentrations of the diluted aliquot. The weight averaged molar mass, the mean square radius, and the second virial coefficient of the macromolecules in solution are derived from an analysis of the angular and concentration dependence of the scattering signals throughout the corresponding peaks. In contrast to earlier on-line methods, better accuracy is achieved, while using a smaller quantity of sample. A similar method for determining cross virial coefficients between two distinct species of macromolecules is also presented.

A new method is presented for characterizing the associative properties of a solution of macromolecules at high concentration. Sample aliquots spanning a range of concentrations are injected sequentially into a light scattering photometer. Equilibrium association constants and association stoichiometry are derived from an analysis of the angular and concentration dependence of the scattering signals. Thermodynamic nonideality, which becomes important at high concentrations, is dealt with in the analysis in a simplified manner which is applicable to multiple associated species.

The invention discloses the application of 3,5-di-tert-butyl copper salicylate in the preparation of medicines for treating highly metastatic breast cancer and the dosage of 3,5-di-tert-butyl copper salicylate. Experiments have proved that copper 3,5-di-tert-butyl salicylate can inhibit the metastasis of breast cancer cells, and inhibit the invasion of breast cancer cells in a concentration-dependent manner. The invention discovers a new medical application for 3,5-di-tert-butyl copper salicylate, and opens up a new application field.

The invention discloses an application of polyketone compounds pestalpolyol A as a drug for treating the alzheimer disease. A caenorhabditis elegans model CL4176 of the alzheimer disease is taken as aresearch target, a commercial medicine galanthamine of the alzheimer disease is taken as positive control, and small molecule compounds capable of effectively inhibiting caenorhabditis elegans CL4176paralysis can be effectively screened from a large quantity of natural products or artificially synthesized compounds. A paralysis experiment result proves that compared with the positive control galanthamine, the added polyketone compounds pestalpolyol A with the same concentration have a better effect on inhibiting caenorhabditis elegans paralysis, the inhibition function has concentration dependence in the concentration range of 100 mu M, and the cytotoxicity is smaller.

The invention discloses a lanthanide-MOF (Metal Organic Framework) doping-based electrostatic spinning fiber membrane serving as a fluorescent sensor and a preparation method thereof. The sensor is applied to the quantitative detection of uric acid in human urine. The detection process comprises the following steps of: (I) synthesizing Eu-PTA-MOF powder; (II) synthesizing a copolymer PMMA / PVP; (III) preparing an electrostatic spinning solution; (IV) preparing a nanofiber membrane; (V) cutting the nanofiber membrane; (VI) inserting the cut membrane into a cuvette; and (VII) recording fluorescence spectrum data. The prepared electrostatic spinning fiber membrane shows various kinds of characteristic blue fluorescence of Eu<3+> and good hydrophilicity and shows good fluorescence detection stability at the pH value of 4.5-8.0 in 30 minutes; the quenching efficiency of the uric acid on the electrostatic spinning fiber membrane fluorescence shows good concentration dependence and anti-interference performance; the detection range of the uric acid is 3-100 [mu]M and the detection limit is 1.3 [mu]M; in addition, the electrostatic spinning fiber membrane can be used repeatedly. The invention provides a simple and efficient method for the quantitative detection of the uric acid in biological fluids.