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Application of artemisinin in preparation of drugs to treat c-myc/mTOR-activated human hepatoma SMMC7721 cells

A technology of p-c-myc and artemisinin, which is applied in the field of medicine and achieves good time- and concentration-dependent effects

Inactive Publication Date: 2019-06-21
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in liver cancer cells, no reports have been found after literature research

Method used

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  • Application of artemisinin in preparation of drugs to treat c-myc/mTOR-activated human hepatoma SMMC7721 cells
  • Application of artemisinin in preparation of drugs to treat c-myc/mTOR-activated human hepatoma SMMC7721 cells
  • Application of artemisinin in preparation of drugs to treat c-myc/mTOR-activated human hepatoma SMMC7721 cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The artemisinin medicine is made into a suppository, and the preparation method is as follows:

[0033] 1) Add 203.7g polyethylene glycol 4000, 101.8g polyethylene glycol 400, 33.9g purified water, 4g Tween-80, and melt at 80°C; 2) Add 50g artemisinin under constant stirring, and then add 4g Vitamin E, stir for 30 minutes to make it uniform; 3) Add the prepared solution into the storage medicine tank of the BZS-1 suppository filling and sealing unit, set the heat preservation temperature to 54°C, start the filling unit, and the filling speed is 3000 capsules per hour to obtain artemisinin suppositories.

[0034] Administration method:

[0035] Common dosage for adults: rectal administration, 0.6g for the first time, 0.6g after 4 hours, 0.4g each on the second and third day.

[0036] Precautions: 1. If you defecate within 2 hours after the anal plug, you should reapply it once.

Embodiment 2

[0038] The artemisinin drug is made into microcapsule particles, and the preparation method is as follows:

[0039] 1) Pass 1-10 mg of artemisinin through a 100-mesh sieve, and dissolve it in ethanol 7 times its weight; 2) Add 20 mg of sodium starch phosphate and 50 mg of Tween emulsifier, and stir evenly to obtain a core material solution; 3) With 10mg of chitosan, 20mg of carboxymethyl chitosan octadecyl quaternary ammonium salt and 50mg of gelatin are used as the wall material, water 7 times the weight of the wall material is added, the temperature is raised to 55°C, and the mixture is evenly stirred to obtain a wall material suspension; 4) Homogenize the above-mentioned core material solution and wall material suspension in a latex ultrasonic homogenizer for 25 minutes according to the weight ratio of 1:4 to obtain an emulsion; 5) Transport the emulsion obtained in step 4) to the granulation spray machine for spray drying, cooled to room temperature, and packaged to obtain...

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Abstract

The invention discloses application of artemisinin in the preparation of drugs to treat c-myc / mTOR-activated human hepatoma SMMC7721 cells. Artemisinin is a colorless needle crystal of sesquiterpene lactone with peroxyl groups, extracted from stems and leaves of the compound inflorescence plant Artemisia annua. In the invention, it is discovered for the first time that artemisinin can inhibit theproliferation of human hepatoma SMMC7721 cells, with good time and concentration dependence presented, can induce apoptosis of the human hepatoma SMMC7721 cells by inhibiting the expression of P-c-mycand P-S6 of c-myc / mTOR pathway, and therefore, can be studied and developed as a candidate drug to induce the apoptosis of human hepatoma SMMC7721 cells.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of artemisinin in the preparation of medicines for treating human liver cancer SMMC7721 cells activated by c-myc / mTOR. Background technique [0002] Liver cancer is the fifth most common cancer and the third leading cause of death worldwide, followed by lung and colon cancers. Liver cancer is a malignant tumor of the liver, which can be divided into two categories: primary and secondary. Primary liver malignant tumors originate from the epithelial or mesenchymal tissues of the liver. The former is called primary liver cancer, which is a malignant tumor with high incidence and great harm in my country; rare. Secondary or metastatic liver cancer refers to malignant tumors originating from multiple organs throughout the body and invading the liver. Generally, it is more common in liver metastases of malignant tumors in stomach, biliary tract, pancreas, ...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P35/00
Inventor 唐玲李雨桐韩鑫龙蔡珂袁立霞汤庆发邢学锋陈飞龙
Owner SOUTHERN MEDICAL UNIVERSITY
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