The invention discloses application and
salvianolic acid B and analogues of the
salvianolic acid B in preparing anti-HPV-viral-infection
medicine, and belongs to the field of
biomedicine. The inventordiscovers that the
salvianolic acid B and the analogues, such as
myricetin and dihydromyricetin, of the
salvianolic acid B for the first time through researches, the
salvianolic acid b and the analogues of the
salvianolic acid B have good anti-HPV-viral-infection activity and can effectively block adhering of HPV viruses to target cells, and then HPV
viral infection is inhibited. Experiments prove that the
salvianolic acid B and
capsid protein of the viruses can be directly bound, and adhesion of
antagonism viruses to the target cells achieves an anti-
virus effect. The salvianolic acid B actsin the early stage that the viruses enter the cells, and can also act in the middle stage and the later stage that the viruses enter the cells. The effects are better than
medicine only acting on theearly stage that the viruses enter the cells in the prior art. The salvianolic acid B is harmless to the
human body in a concentration range where the salvianolic acid B can achieve the anti-
virus function. It is very likely that the salvianolic acid B is developed into a novel
microbicide for preventing and treating HPV and other sexually transmitted
viral infection.