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Preparation method and application of a kind of lignan compound

A technology of lignans and compounds, which is applied in the field of medicine, can solve the problems of unknown active ingredients, unclear substances that act on liver diseases, etc., and achieve the effect of reducing the content

Active Publication Date: 2021-01-01
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its related varieties are mostly used clinically for diseases related to the liver. However, the main active ingredients in Qingfengteng are unknown at present, and the active substances of its liver diseases are still unclear

Method used

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  • Preparation method and application of a kind of lignan compound
  • Preparation method and application of a kind of lignan compound
  • Preparation method and application of a kind of lignan compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: preparation embodiment

[0032] The preparation method of a kind of new lignans compound in Teng chrysantha, comprises the following steps:

[0033] (1) Take the dried medicinal material of Qingfengteng, add 12 times the concentration of 70% ethanol for reflux extraction each time, the number of extractions is three times, and the three extraction times are 3 hours, 2 hours, and 1.5 hours respectively, filter, and combine the extracts, Concentrate under reduced pressure to obtain the extract;

[0034] (2) Take the extract from step (1) and dissolve it with 20% ethanol, filter to remove the insoluble matter, obtain the supernatant, apply it to HP-20 resin (medicine resin ratio 1:3), and elute 3 columns with water Volume, remove water-soluble impurities, and then elute with 20% ethanol solution for 3 column volumes, combine the eluents, and concentrate to obtain the elution site;

[0035] (3) Dissolve the elution fraction obtained in step (2) with 70% etha...

Embodiment 2

[0036] Embodiment 2: preparation embodiment

[0037] The preparation method of a kind of new lignans compound in Teng chrysantha, comprises the following steps:

[0038] (1) Take the dried herbal material of Qingfengteng, add 10 times the concentration of 50% ethanol for reflux extraction each time, the number of extractions is three times, and the three extraction times are 3 hours, 2 hours, and 1.5 hours respectively, filter, and combine the extracts, Concentrate under reduced pressure to obtain the extract;

[0039] (2) Take the extract from step (1) and dissolve it with 20% ethanol, filter to remove the insoluble matter, obtain the supernatant, apply it to HP-20 resin (medicine resin ratio 1:3), and elute 3 columns with water Volume, remove water-soluble impurities, and then elute with 20% ethanol solution for 3 column volumes, combine the eluents, and concentrate to obtain the elution site;

[0040] (3) Dissolve the elution fraction obtained in step (2) with 70% ethanol...

Embodiment 3

[0041] Embodiment 3: preparation embodiment

[0042]The preparation method of a kind of new lignans compound in Teng chrysantha, comprises the following steps:

[0043] (1) Take the dried herbal material of Qingfengteng, add 14 times the concentration of 70% ethanol for reflux extraction each time, the number of extractions is three times, and the three extraction times are 3 hours, 2 hours, and 1.5 hours respectively, filter, and combine the extracts, Concentrate under reduced pressure to obtain the extract;

[0044] (2) Take the extract from step (1) and dissolve it with 20% ethanol, filter to remove the insoluble matter, obtain the supernatant, apply it to HP-20 resin (medicine resin ratio 1:3), and elute 3 columns with water Volume, remove water-soluble impurities, and then elute with 25% ethanol solution for 3 column volumes, combine the eluents, and concentrate to obtain the elution site;

[0045] (3) Dissolve the elution fraction obtained in step (2) with 70% ethanol,...

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Abstract

The invention relates to the technical field of medicines, in particular to a preparation method of a lignan compound in sabia parviflora and an application thereof, and further provides an application of the lignan compound in preparation of medicines or health care products for preventing and treating fatty liver injury. The pharmacological studies show that the compound provided by the invention can significantly reduce a large amount of cell apoptosis caused by FFA treatment of LO2 cells, can reduce the cell apoptosis rate caused by FFA when the concentration of the compound is greater than 2.5 [mu]g / ml, and has concentration dependence; meanwhile, when the concentration of the compound is greater than 2.5 [mu]g / ml, the content of Albumin can be up-regulated; the activity of AST and ALT is weakened, and the content of TG is reduced, so that the compound has a protective effect on FFA-induced liver normal cell damage, and is expected to be developed into a new medicine or health care product for preventing and treating fatty liver injury diseases.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a preparation method and application of a lignan compound in Teng hua qingfeng. Background technique [0002] Xiaohua Qingfengteng is a liana of Qingfeng rattan family Qingfeng rattan, Xiaohua Qingfengteng Sabia parviflora Dried stems and leaves of Wall. exRoxb. The small flower Qingfengteng produced in Guizhou is a folk medicine of the Buyi and Miao nationalities. It is mainly distributed in Xingyi City, Anlong County, Ceheng County, Wangmo County and other places in Guizhou. Its rhizomes and leaves can be used as medicine. Anti-inflammatory and analgesic effects, the treatment of viral hepatitis A and B has remarkable curative effect, and the side effects are small. Its related varieties are mostly used clinically for diseases related to the liver. However, the main active ingredients in Qingfengteng are unknown at present, and the active substances of its liver diseases ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08A61P1/16A23L33/105
CPCA23V2200/00A23L33/105A61P1/16C07H1/08C07H15/18A23V2200/30
Inventor 李志峰冯育林王琦杨世林钟国跃杜伟东粟杰林炳锋
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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