Panaxadiol-type triterpene saponins with anti-inflammatory activity

A technology of ginseng diol and triterpene saponins, which is applied in the direction of organic active ingredients, anti-inflammatory agents, and medical preparations containing active ingredients, etc., can solve the problems of limited growth environment and insufficient resources of Panax notoginseng, and achieve the effect of inhibiting release
CN110922444BActive Publication Date: 2022-04-15TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Publication Date
2022-04-15

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Abstract

The present invention utilizes a variety of separation means, including forward and reverse phase silica gel column chromatography, macroporous adsorption resin column chromatography, gel column chromatography and preparation of high performance liquid chromatography, etc., and obtains 7 leaves of Panax notoginseng Panaxadiol-type triterpene saponins including new compounds. These 7 new compounds have been shown to have anti-inflammatory activity by activity assay, which has laid a material foundation for further pharmacological activity screening and clinical research to develop anti-inflammatory drugs with definite curative effect and less toxic and side effects.
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Description

technical field

[0001] The invention belongs to the field of natural medicines, and in particular relates to a class of novel panaxadiol-type triterpene saponins with anti-inflammatory activity. Background technique

[0002] Inflammation is a basic pathological process in which the living tissue with vascular system is stimulated by various damage factors and is mainly a defense response. Anything that can cause tissue damage can be a cause of inflammation. The basic pathological changes of inflammation usually include degeneration, exudation and hyperplasia of local tissues. Inflammation is closely related to the occurrence and development of various diseases such as diabetes, tumors, and cardiovascular and cerebrovascular diseases.

[0003] Panax notoginseng (Burk.) F.H.Chen is a plant of the genus Panax of the family Araliaceae, also known as Tianqi, blood ginseng, Tianzhi, Dianzhi, and Sanqi. It is mainly produced in Wenshan Prefecture, Yunnan, and in Guangxi, Guangdon...

Claims

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