143 results about "Anti inflammatories" patented technology

A construction and use of an environmentally adaptive co-regulated mRNA nanodelivery system. By incorporating EACR molecules into mRNA nanoparticles, the microenvironment is remodeled to be suitable for robust and sustained mRNA expression, while tissue damage associated with the self-immunogenicity of mRNA drugs is avoided. The nanodelivery system is compatible with ionizable lipid nanoparticles, cationic liposomes, cationic nanoemulsions, and polymeric nanoparticles. The EACR molecules include: anti-inflammatory drugs, tyrosine kinases / adaptors, JAK / STAT and MAPK pathway inhibitors, nutrients and metabolites, membrane transporters / ion channels, phosphodiesterase and cellular stress inhibitors, and natural viral proteins. The therapeutic mRNAs may encode tumor, viral, or bacterial antigens, immunomodulatory factors, therapeutic antibodies, or functional proteins / enzymes, and can play a role in the fields of regenerative medicine, protein supplementation / replacement therapy, targeted gene editing, and immunotherapy.

The invention discloses a hydrogel microsphere system for sequential delivery of drugs as well as a preparation method and application thereof, and particularly relates to the technical field of biomedical materials. The microsphere system comprises inflammation responsive hydrogel microspheres obtained by grafting molecules containing inflammation responsive groups with hyaluronic acid as a skeleton, common microspheres obtained by grafting non-responsive molecules with hyaluronic acid as a skeleton, an anti-inflammatory drug and a healing promoting drug. Wherein the molecular weight of the hyaluronic acid is 74-800kDa, the inflammation responsive hydrogel microspheres are loaded with anti-inflammatory drugs, and the common microspheres are loaded with healing promoting drugs. According to the hydrogel microsphere system, the drug release rate and degradation time of the microspheres are adjusted by limiting the molecular weight of hyaluronic acid, and a molecular basis is provided for subsequent differentiated drug release.

The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.

The invention relates to the technical field of biological materials, and particularly discloses catechol and metal ion-based nano-microspheres as well as a preparation method and application thereof. The catechol and metal ion-based nano-microspheres are prepared from catechol-based small molecules, metal ions, ammonia water, an organic solvent and water; the catechol-based small molecules comprise catechol, gallic acid or dopamine, and the concentration of the catechol-based small molecules is 5-50 mM. The metal ions comprise Mg < 2 + >, Zn < 2 + >, Ca < 2 + > or Cu < 2 + >, and the concentration is 2.5 mM to 25mM. The content of the ammonia water is 5vol%-10vol%. The preparation method comprises the following steps: dissolving catechol-based micromolecular monomers and metal ions in a mixed solution of an organic solvent and water, and continuously stirring for reaction to obtain the nano-microspheres. The prepared nano-microspheres have excellent cell compatibility, can be used for inflammation treatment and tissue regeneration and repair, and can be used for preparing anti-inflammatory drugs and drugs for promoting tissue repair and regeneration in the biomedical field.

The invention discloses a neuroprotective peptide with anti-inflammatory and anti-oxidation effects and application of the neuroprotective peptide. The neuroprotective polypeptide is a polypeptide with any one of the following sequences: FPDFVYK and APDTRLF. The invention provides an antioxidant effect of the neuroprotective polypeptide in a PC12 cell injury model induced by hydrogen peroxide, and the neuroprotective polypeptide can be used for preparing antioxidant drugs. The invention provides an anti-inflammatory effect of the neuroprotective polypeptide in a PC12 cell injury model induced by hydrogen peroxide, and the neuroprotective polypeptide can be used for preparing anti-inflammatory drugs. The invention provides the influence of the neuroprotective polypeptide on the expression of pathways and neurotrophic factors in PC12 nerve cells. The neuroprotective polypeptide reduces the activity of acetylcholin esterase (AChE) and up-regulates the expression of neurotrophic factors so as to alleviate nerve cell damage and enhance memory, thereby achieving the purpose of preventing and treating neurodegenerative diseases.

The invention belongs to the technical field of natural pharmaceutical chemistry, and discloses a flavonoid compound in lomatogonium radiatum as well as a preparation method and application thereof.The flavonoid compound is separated from lomatogonium radiatum of a gentiaceae lomatogonium plant, the medicinal material of lomatogonium radiatum is extracted and concentrated, and the flavonoid compound is obtained. And sequentially carrying out macroporous adsorption resin separation, gel column chromatography separation, medium-low pressure ODS column chromatography separation and semi-preparative high performance liquid chromatography separation. Pharmacological studies show that the compound provided by the invention can effectively inhibit the levels of COX2, IL-6 and TNF-alpha in mouse macrophages RAW246.7 caused by lipopolysaccharide (LPS), which indicates that the compound has obvious anti-inflammatory activity and can be used for preparing anti-inflammatory drugs.

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The application discloses a psoralen derivative or a pharmaceutical salt thereof, and a structure general formula of the psoralen derivative is shown in the following formula: The psoralen derivative is obtained by optimizing the structure of psoralen, and the antibacterial activity test is carried out on common gram-positive bacteria such as drug-resistant staphylococcus aureus and gram-negative bacteria such as escherichia coli and klebsiella pneumoniae, and it is found that the compound or the pharmaceutical salt thereof has excellent anti-drug-resistant bacteria, anti-inflammatory and anti-tumor activities, and has good development value in preparation of anti-infection treatment drugs, anti-inflammatory drugs and anti-tumor drugs.

The present invention discloses an anti-inflammatory compound, its biosynthetic gene cluster, synthesis method and application, belonging to the technical field of genetic engineering. An anti-inflammatory compound is provided, and the chemical molecular formula of the anti-inflammatory compound is C<subgt;15< / subgt;H<subgt;22< / subgt;O<subgt;5< / subgt>, and the structural formula is shown in Formula I, named: phaseolinone B. The present invention first discloses the biosynthetic pathway of the anti-inflammatory compound phaseolinone B, laying an important foundation for realizing its green and efficient synthesis; this compound exhibits significant anti-inflammatory activity in the zebrafish Tg 3dpf tail amputation infection model, providing resources for discovering anti-inflammatory drug lead compounds.

The invention provides an application of 10E, 12Z-octadecadienoic acid in inhibition of inflammatory reactions, and the inflammatory reactions comprise macrophage inflammatory reactions induced by lipopolysaccharide. According to the invention, a mouse mononuclear macrophage RAW264.7 cell inflammatory response model is constructed. The method comprises the following steps: firstly, measuring CC50 of 10E, 12Z-octadecadienoic acid by a CCK-8 method; 10E, 12Z-octadecadienoic acid is used for pretreating macrophages for 24 hours before lipopolysaccharide stimulation at the final concentration of 25 mu mol / L to 100 mu mol / L, qPCR (quantitative polymerase chain reaction) and ELISA (enzyme-linked immuno sorbent assay) experiments prove that the 10E, 12Z-octadecadienoic acid plays an anti-inflammatory role by inhibiting mRNA (messenger ribonucleic acid) expression and protein secretion of IL-6, IL-1beta and / or TNF-alpha, and the anti-inflammatory effect is optimal at the final concentration of 100 mu mol / L. The 10E, 12Z-octadecadienoic acid is a single unmodified fatty acid isomer, is clear in structure, good in anti-inflammatory effect repeatability and good in biocompatibility, and can reduce adverse reactions compared with traditional anti-inflammatory drugs; compared with existing fatty acid anti-inflammatory components, the composition is clear in component and simple and convenient to prepare. The application scenarios of the invention cover the development of anti-inflammatory drugs, functional foods and biological agents.

The invention relates to the technical field of organic synthetic chemistry, in particular to a preparation method and medical application of selenophosphate promoted by tris (pentafluorophenyl) borane. The preparation method of the selenophosphate ester comprises the following steps: under the action of tris (pentafluorophenyl) borane, taking seleno cyanate ester and phosphate ester as reaction raw materials, and carrying out stirring reaction under a certain temperature condition to obtain the selenophosphate ester compound. The synthesis method is mild in condition, does not need a metal catalyst and an oxidizing agent, and accords with the idea of green chemistry. The method also has the advantages of simplicity in operation, few byproducts, high purity and the like. In-vitro anti-inflammatory experiments prove that the selenophosphate compound disclosed by the invention has remarkable anti-inflammatory activity, can effectively inhibit the generation of inflammatory factors and cell inflammatory response, can be used as an active ingredient of anti-inflammatory drugs, and has a wide clinical application prospect.

The invention discloses a lipidosome composite hydrogel microsphere for repairing damaged intestinal mucosa and a preparation method thereof, LHMs (at) 4-OI is composed of hyaluronic acid modified targeted drug-loaded lipidosome, sodium alginate, hydrochloric acid treated sucralfate and a CaCl cross-linking agent, and rapid gel forming is carried out under the voltage of 11.0 KV through an electrospray technology. The microspheres have pH responsiveness and gastric juice digestion resistance, CD44 receptor targeting is achieved through hyaluronic acid modification, sodium alginate and Ca form an egg box structure to provide a three-dimensional network, and sucralfate enhances adhesion to isolate harmful substances. The preparation method comprises the steps of preparation of the drug-loaded liposome by a film hydration method, hyaluronic acid modification and electrospray crosslinking, is simple to operate and low in cost, and can be used for large-scale production. The microspheres can effectively load an anti-inflammatory drug 4-OI, inhibit expression of inflammatory factors and promote self-repair of damaged intestinal mucosa, and have wide application prospects in the fields of abdominal infection, inflammatory bowel diseases, colorectal cancer and the like.

The present application relates to the field of eggshell membrane peptide, in order to solve the problem that the proportion of polypeptide with main function of anti-inflammatory effect is low in the eggshell membrane peptide product obtained by hydrolysis of existing eggshell membrane, provide an eggshell membrane peptide and a preparation method thereof, and an application of the eggshell membrane peptide in preparation of anti-inflammatory drugs, comprising: S100, after adding eggshell membrane powder into pure water, adjusting pH, then adding pepsin, enzymolysis for 2-5h, and the enzymolysis temperature is 35-38 DEG C, to obtain a first mixture; S200, the first mixture is subjected to enzyme inactivation process and ultrafiltration process to obtain a first hydrolysate and a first ultrafiltrate; S300, after adjusting the pH value of the first ultrafiltrate to 8-9, adding alkaline protease, enzymolysis for 6-10h, and the enzymolysis temperature is 36-38 DEG C, to obtain a second mixture; S400, the second mixture is subjected to ultrafiltration process to obtain a second ultrafiltrate and a second hydrolysate; S500, after drying the second hydrolysate, a first polypeptide composition is obtained. The present application explores the effect of different hydrolysate components on chondrocyte anti-inflammatory, and screens out eggshell membrane peptides with better effect.

The application discloses a pterosin sesquiterpenoid compound and a preparation method and application thereof, belongs to the technical field of biological medicines, aims at the problems of a research blank of pterosin sesquiterpenoid compounds in Anemone raddeana and a lack of structure-confirmed anti-inflammatory active monomers, and provides a pterosin sesquiterpenoid compound with a structural formula as shown in the following.The compound preparation needs to first crush dried whole grass of Anemone raddeana, extract by heating and refluxing with an organic solution, concentrate under reduced pressure to obtain total extract; then, the extract is extracted by petroleum ether, ethyl acetate and n-butanol step by step, the ethyl acetate part extract is enriched, and the high-purity product is prepared through multi-step purification of a silica gel column, a C-18 reverse phase column, a gel column and semi-preparative liquid chromatography.In addition, the compound can dose-dependently inhibit the NO release of LPS-induced macrophages, and can be used for preparing anti-inflammatory drugs for treating or preventing inflammatory diseases related to excessive production of nitric oxide, fills the research blank, and provides a high-quality candidate component for anti-inflammatory drug research and development.

The present application relates to the technical field of biological medicine, in particular to streptomyces AH1901-2 and application thereof, preparation method and application of naphthymycin compounds, and belongs to the field of biological medicine. The streptomyces AH1901-2 is isolated from rhizosphere soil of Ligularia sibirica in Tianshan region (5.8°E, 28.0°N) in Xinjiang, and naphthymycin compounds are isolated and purified from liquid fermentation liquor of the streptomyces AH1901-2, and subsequent studies show that the naphthymycin compounds have obvious inhibitory effect on NO production of mouse mononuclear macrophages, and can be used for preparing anti-inflammatory drugs and treating inflammation.

The invention discloses application of an aromatic hydrocarbon receptor stimulant in preparation of a medicine for treating diarrhea of weaned piglets and / or inhibiting inflammation, and belongs to the field of biological medicine. According to the present invention, with the PAS-B structural domain of the AHR as the target, the virtual screening technology, the target verification test and the weaned piglet diarrhea pharmacodynamic evaluation test are performed to determine the arctigenin as the AHR strong agonist and the anti-inflammatory drug, and the arctigenin has the good treatment effect on the weaned piglet diarrhea. Experimental results show that 10 mg / kg of arctigenin can significantly relieve diarrhea and hemafecia symptoms of weaned piglets, reduce the content of inflammatory factors in serum and intestinal tissues and improve the intestinal structure of weaned piglets, has no significant cytotoxicity, hepatorenal toxicity and intestinal epithelial cell growth inhibition effect, and can be used for preparing a feed additive for weaned piglets. The compound can be used for preparing medicines for treating diarrhea of weaned piglets. The invention provides a new raw material medicine for treating diarrhea of weaned piglets, and has great economic value and wide application prospect.

The invention provides a rehmannia pigment compound as shown in a formula (I), a stereoisomer thereof or pharmaceutically acceptable salt thereof, and particularly relates to the technical field of natural pharmaceutical chemistry and pharmaceutical compounds. The invention aims to solve the problems that the radix rehmanniae pigment is not clear in material basis and lacks a compound with a clear structure and excellent anti-inflammatory activity. The rehmannia pigment compound disclosed by the invention comprises a structure as shown in a formula (I). The invention also discloses a preparation method of the compound and application of the compound in medicines. The compound has a novel chemical structure and remarkable anti-inflammatory activity, release of nitric oxide can be effectively inhibited in a lipopolysaccharide induced macrophage model, the cytotoxicity is far lower than that of a positive control drug quercetin, and the compound shows huge potential as an anti-inflammatory drug lead compound.

The present application relates to tetrahydroprotoberberine THPB derivatives, and particularly relates to application of a tetrahydroprotoberberine THPB derivative GP10 in preparation of a medicine for improving or treating epilepsy and neuroinflammation; the new candidate compound GP10 discovered by the present application has significant anti-epilepsy activity, not only expands the pharmacological effect spectrum of THPBs, but also provides a new strategy for research and development of anti-epilepsy drugs or auxiliary treatment drugs. Meanwhile, the present application research proves that GP10 can interfere with the structure of DAMP molecules, affect the combination of DAMP molecules and PRR and the downstream signal transduction, and the mechanism is verified through in-vivo and in-vitro experiments, which provides a new theoretical basis and thought for development of anti-inflammatory drugs.

The invention provides application of a virtual screening compound in preparation of an NLRP3 inflammasome inhibitor, and relates to the technical field of medicines.The application is characterized in that NLRP3 protein is used as a target point, and LRamp is adopted; an RF-ECFP4 integrated machine learning model is used for carrying out preliminary screening on a ZINC compound database, and nine small molecule compounds with high binding affinity are finally obtained by combining molecular docking, clustering analysis, in-vitro activity detection and ADMET property prediction. Experimental results show that the compounds can be stably combined with NLRP3 protein key residues, can significantly inhibit expression of inflammatory factors IL-1beta, IL-18 and TNF-alpha in an in-vitro level, and show good drug-likeness, oral absorption characteristic and safety. The compounds can be used for preparing drugs for treating NLRP3 inflammasome abnormal activation related diseases, and important lead compounds are provided for developing novel anti-inflammatory drugs.

The present application relates to the technical field of gel dressing, in particular to a concentrated growth factor gel dressing based on broad-spectrum active oxygen cluster scavenging nanoparticles and a preparation method and application thereof. The present application uses 4-hydroxy-2,2,6,6-tetramethylpiperidine nitroxide and 4-hydroxymethylphenylboronic acid pinacol ester to modify and combine a skeleton molecule such as glucose to construct degradable nanoparticles, so that the nanoparticles can be combined with concentrated growth factors derived from platelets to form a gel, effectively scavenge different types of active oxygen such as free radicals, superoxide anions, hydrogen peroxide and hypochlorite generated in a refractory wound environment, and promote wound healing in combination with the repair-promoting effect of CGF cytokines. The present technical solution can solve the technical problem of the lack of platelet glue containing broad-spectrum active oxygen cluster scavenging materials with good compatibility and therapeutic effect in the prior art, and can be used to prepare active oxygen scavenging drugs, anti-inflammatory drugs and drugs for promoting wound healing, and has a good application prospect.

The present invention relates to a composition for preventing, improving and treating an inflammatory macrophage-mediated autoimmune disease, including a stem cell-derived exosome surface-modified with a sugar compound to target an activated macrophage, and the composition according to the present invention may specifically target an activated macrophage to increase the therapeutic efficiency for various types of autoimmune diseases including rheumatoid arthritis. In addition, the composition according to the present invention has a more excellent therapeutic effect and minimizes side effects compared with conventional antiinflammatory agents, stem cell therapeutic agents or exosomes because it contains a gene, protein or growth factor related to the proliferation, differentiation and regeneration of stem cells, and does not include an antibiotic or serum, or harmful factors of the cell culture.

The present application provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, and uses thereof in treating or preventing inflammation, reducing release of inflammatory factors (especially inflammatory factors of immune cells), treating or preventing diseases associated with excessive release of inflammatory factors, inhibiting a cGAS-STING pathway, or treating diseases associated with the cGAS-STING pathway. (I)

The invention discloses a 1, 10-split ring type guaiane sesquiterpene lactone quasi-natural product as well as a preparation method and application of the 1, 10-split ring type guaiane sesquiterpene lactone quasi-natural product. The quasi-natural product and the derivative thereof are prepared by taking (R)-Carvone as a raw material through a chemical synthesis method. Experiments show that the 1, 10-split ring type guaiane sesquiterpene lactone compound prepared by the invention has the effect of inhibiting red blood cell hemolysis, can be used as a candidate drug molecule for preventing and / or treating NLRP3 inflammasome related diseases, and has the potential of being developed into related anti-inflammatory drugs.

The invention discloses a method for improving the yield and purity of cyclic peptide compounds produced by aspergillus fermentation and application, components of a fermentation culture medium for producing the cyclic peptide compounds by aspergillus fermentation are optimized through a single factor test and an orthogonal test, and it is found that the yield of JBIR-15 is effectively improved by adding a certain amount of amino acid, the yield reaches 984 mg / L, and the yield of the JBIR-15 reaches 984 mg / L. The yield of JBIR-15 (321mg / L) is increased by about 3.07 times compared with that of JBIR-15 (321mg / L) The purity is greater than or equal to 95%, the biological activity is effectively improved, and the compound can be used for preparing anti-tumor drugs and / or anti-inflammatory drugs.

The present application relates to the technical field of separation and purification of Schizonepeta tenuifolia Briq, and relates to a biphenyl compound in Schizonepeta tenuifolia Briq, a preparation method thereof and application of the biphenyl compound as an anti-inflammatory drug. The biphenyl compound in Schizonepeta tenuifolia Briq is obtained by the following steps: soaking Schizonepeta tenuifolia Briq, heating and reflux extraction, recovering and concentrating under reduced pressure, obtaining total extract of Schizonepeta tenuifolia Briq, extracting and concentrating with petroleum ether, dichloromethane and ethyl acetate, obtaining a dichloromethane part extract, gradient elution separation of the dichloromethane part extract, gradient elution separation of the fourth fraction of the obtained eight fractions, gradient elution separation of the third fraction of the obtained six fractions, gradient elution separation of the fifth fraction of the obtained eight fractions, purification and separation of the eluate, and collection of the eluate, and the biphenyl compound in Schizonepeta tenuifolia Briq is obtained at 16.4 minutes. The present application discloses the biphenyl compound in Schizonepeta tenuifolia Briq for the first time, and in vitro anti-inflammatory pharmacodynamic experiments are carried out, which prove that the biphenyl compound has a certain inhibitory effect on RAW264.7 cells and can be applied to preparation of anti-inflammatory drugs.

This invention discloses a method for constructing and evaluating a homeostatic neuroinflammatory microenvironment model. In this invention, brain microvascular endothelial cells and microglia are seeded into the methacrylamide gelatin layer and the paper fiber layer of a methacrylamide gelatin-paper fiber composite membrane (GCC), respectively, and co-cultured for 24–96 hours without LPS stimulation to form a homeostatic neuroinflammatory microenvironment model. The 24-hour GCC group… TNF-alpha Compared to the PET group, CX3CL1 decreased by about 60% and remained at a low level for 72 hours; CX3CL1 increased by nearly 3 times in the GCC group; based on the evaluation of 4 / 10 / 70 kDa graded probes, GCC showed better restriction on 10 kDa than PET, exhibiting molecular weight-dependent permeation characteristics opposite to PET. The homeostatic neuroinflammatory microenvironment model proposed in this application is suitable for simulating the blood-brain barrier in early pathological conditions, and can be used for anti-inflammatory drug screening and research on neurodegenerative diseases, showing good application prospects.

The invention discloses a method for preparing an acetylglucosamine derivative through biotransformation of marine microbacterium and application of the acetylglucosamine derivative, the marine microbacterium is microbacterium HN-3-14 and has been preserved in Guangdong Microbial Culture Collection Center on March 3, 2025, and the preservation number is GDMCC No.65964. The invention further discloses a preparation method of the acetylglucosamine derivative through biotransformation of the marine microbacterium HN-3-14. The method comprises the following specific steps: inoculating a microbacterium seed solution into a special culture medium, carrying out fermentation culture and HPLC separation to obtain four acetanilide derivatives formed by biotransformation of microbacterium HN-3-14, and exploring the cytotoxicity and anti-inflammatory activity of the obtained derivatives, so that the method is expected to be applied to preparation of anti-inflammatory drugs.

The invention belongs to the field of traditional Chinese medicine extracts, and relates to a triterpenoid alkaloid compound as well as a preparation method and application thereof. The triterpenoid alkaloid compound is separated from euonymus japonicus for the first time, and it is proved that the triterpenoid alkaloid compound has remarkable anti-inflammatory activity and anti-tumor activity and has good application prospects in preparation of anti-inflammatory drugs and anti-tumor drugs. The preparation method comprises the following steps: taking dry euonymus japonicus as a raw material, sequentially carrying out heating reflux extraction for multiple times by using methanol, extracting an alkaloid-rich part by using an acid extraction and alkali precipitation method, carrying out preliminary segmentation by means of normal-phase silica gel column, amino silica gel column, gel column chromatography and the like, and carrying out refining purification by a preparative thin-layer chromatography, a semi-preparative high performance liquid chromatograph and the like. The preparation method is easily available in raw materials, environment-friendly, simple to operate and suitable for industrial production.

The application discloses a preparation method of a 3D printing anti-inflammatory biodegradable airway stent, and provides a new solution for rapidly preparing a personalized biodegradable airway stent for clinical application. The preparation method comprises the following steps: preparing a customized airway stent by using a 3D printing technology; obtaining an amine crosslinked stent by using a surface modification method; and further obtaining an anti-inflammatory airway stent by using an amidation reaction between ibuprofen and the surface amino group. The process has good repeatability and excellent personalized customization performance, and can be used as an effective means for treating central airway obstruction.

The present application relates to the technical field of medicine and cosmetics, and provides a paeonol phosphate ester, a preparation method therefor, and a use thereof. The paeonol phosphate ester of the present application is a novel compound, and the preparation method is simple and easy to perform. Esterifying a phenolic hydroxyl group in a paeonol structure prevents the characteristic odor associated with small-molecule phenolic compounds, and also addresses the disadvantage of poor cold-water solubility of paeonol. Research indicates that the paeonol phosphate ester provided in the present application exhibits stronger anti-inflammatory activity than paeonol, and can be used in the preparation of anti-inflammatory drugs or cosmetics.