Aromatic heterocycle substituted acridine quaternary ammonium salt derivative as well as preparation method and application thereof

A technology of aromatic heterocycles and quaternary ammonium salts, applied in the field of pharmaceutical compounds, can solve the problems of high side effects and antibacterial activity to be further improved, and achieve good bactericidal effect and significant interference effect
CN113444080AActive Publication Date: 2021-09-28SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2021-09-28

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Abstract

The invention belongs to the technical field of pharmaceutical compounds, and relates to an aromatic heterocycle substituted acridine quaternary ammonium salt derivative and a preparation method and application thereof, the aromatic heterocycle substituted acridine quaternary ammonium salt derivative has a structure as shown in a formula (I): wherein R1 is selected from aromatic heterocycle and substituted aromatic heterocycle ; and X is halogen or benzenesulfonic acid anion. The invention provides the aromatic heterocycle substituted acridine quaternary ammonium salt derivatives and the preparation method and application thereof, the aromatic heterocycle substituted acridine quaternary ammonium salt derivatives are designed and synthesized by simplifying the structure, intercepting effective fragments in sanguinarine and berberine, and splicing the effective fragments with aromatic heterocycle pharmacophores. The unique antibacterial effect is expected to be exerted through a dual antibacterial mechanism of inhibiting bacterial FtsZ and bacterial biofilm.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical compounds, and relates to acridinium quaternary ammonium salt derivatives substituted by aromatic heterocycles, a preparation method and application. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] The discovery of antibiotics is hailed as one of the greatest achievements in the history of human medicine. Its wide application not only significantly improves the quality of human life, but also effectively prolongs the overall life span of human beings. At present, more than 200 kinds of antibiotics have been used clinically, and diseases caused by various bacterial infections have also be...

Claims

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