Patents
Literature
3 results about "FtsZ" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division. FtsZ is a prokaryotic homologue of the eukaryotic protein tubulin. The initials FtsZ mean "Filamenting temperature-sensitive mutant Z". The hypothesis was that cell division mutants of E. coli would grow as filaments due to the inability of the daughter cells to separate from one another. FtsZ is found in almost all bacteria, many archaea, all chloroplasts and some mitochondria, where it is essential for cell division. FtsZ assembles the cytoskeletal scaffold of the Z ring that, along with additional proteins, constricts to divide the cell in two.
Mycoplasmic adhesion protein ftsz of bovine mycoplasma and application thereof
PendingCN122104744ABacterial antigen ingredientsAntibacterial agentsCell-Extracellular MatrixECM Protein
The application discloses a Mycoplasma bovum adhesion protein FtsZ and application thereof. The nucleic acid sequence of the Mycoplasma bovum adhesion protein FtsZ is shown as SEQ ID NO. 1. The application also discloses a recombinant plasmid pET-30a-ftsZ and an E. coli containing the recombinant plasmid pET-30a-ftsZ. ftsZ The recombinant protein rFtsZ has the advantages of being capable of specifically combining with EBL cell membrane protein, being capable of combining with extracellular matrix components (fibronectin, fibronectin, laminin and type IV collagen), having the direct adhesion host cell effect, having good antigenicity, being capable of producing high-level antibodies, being capable of providing good immune protection effect, and providing a new target and thought for elucidating the pathogenic mechanism of the Mycoplasma bovum and developing a new vaccine and medicine.
Owner:LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES(LANZHOU BRANCH CENTER OF CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENTER)
Use of bacterial division protein ftsz inhibitor db1 in preparation of drug against drug-resistant bacteria
ActiveCN121337813BEnhanced inhibitory effectIncreased sensitivityFtsZMethicillin resistant Staphylococcus
This invention discloses the application of the bacterial fission protein FtsZ inhibitor DB1 in the preparation of drugs against drug-resistant bacteria, belonging to the field of drug development technology. The inhibitor provided by this invention is compound DB1, named 3-(2,8-dibromo-10,11-dihydro-5H-dibenzo[b,f]azapheno-5-yl)-N,N-dimethylpropylamine hydrochloride, with the molecular formula C2. 19 H 24 Br2ClN2. This compound, DB1, exhibits significant inhibitory effects against various drug-resistant bacteria, particularly vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus (MRSA), and can significantly improve the susceptibility of methicillin to MRSA. The discovery of compound DB1 provides new ideas and technical support for the preparation of drugs against drug-resistant bacteria.
Owner:Guangzhou Cadre and Talent Health Management Center (Guangzhou Talent Training Institute, Guangzhou Eleventh People’s Hospital, Guangzhou Public Employee Mental Health Service Center)
Application of bacterial division protein FtsZ inhibitor DB1 in preparation of drugs for resisting drug-resistant bacteria
ActiveCN121337813AAntibacterial agentsHeterocyclic compound active ingredientsFtsZMethicillin resistant Staphylococcus
The invention discloses application of a bacterial division protein FtsZ inhibitor DB1 in preparation of drugs for resisting drug-resistant bacteria, and belongs to the technical field of drug research and development. The inhibitor provided by the invention is a compound DB1, the name of the compound DB1 is 3-(2, 8-dibromo-10, 11-dihydro-5H-dibenzo [b, f] azepine-5-yl)-N, N-dimethyl propylamine hydrochloride, and the molecular formula of the compound DB1 is C19H24Br2ClN2. The compound DB1 has a remarkable inhibition effect on various drug-resistant bacteria, particularly has a very strong inhibition effect on vancomycin-resistant enterococcus and methicillin-resistant staphylococcus aureus, and can be used for remarkably improving the sensitivity of methicillin to the methicillin-resistant staphylococcus aureus. The discovery of the compound DB1 provides a new thought and technical support for preparation of drugs for resisting drug-resistant bacteria.
Owner:Guangzhou Cadre and Talent Health Management Center (Guangzhou Talent Training Institute, Guangzhou Eleventh People’s Hospital, Guangzhou Public Employee Mental Health Service Center)