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Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone

a technology of albendazole and wolbachia, which is applied in the field of filarial disease drugs, can solve the problems of simultaneous targeting other nematode infections as well, and achieve the effect of reducing the risk of infection

Inactive Publication Date: 2018-06-28
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Albendazole sulfone exhibits anti-Wolbachia activity equivalent to Doxycycline, effectively reducing Wolbachia infection and disrupting FtsZ, providing a more specific targeting mechanism that distinguishes between nematode infections, potentially reducing the persistence of filarial parasites in co-infection areas.

Problems solved by technology

A significant drawback of antihelminthic therapies currently used to treat River Blindness and Lymphatic filariasis is that they simultaneously target other nematode infections as well.
This is a particular problem in areas where people are co-infected with Loa Loa and either O. volvulus or B. malayi.

Method used

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  • Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone
  • Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone
  • Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone

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Embodiment Construction

[0025]Wolbachia bacteria carried by filarial nematodes give rise to the neglected diseases African River Blindness and Lymphatic Filariasis in millions of people worldwide. In effort to identify new anti-Wolbachia therapies, we conducted a high-throughput chemical screen using Wolbachia-infected tissue culture cells. This screen yielded several compounds that resembled Albendazole, an antihelminthic drug used to treat millions of people with neglecte disease. Follow-up testing of Albendazole and its metabolites in Drosophila oogenesis showed that the metabolite Albendazole sulfone exerted anti-Wolbachia activity equivalent to Doxycycline. Immunostaining indicated that Albendazole sulfone treatment disrupts Wolbachia FtsZ, a key binary fission protein, in Brugia malayi nematodes associated with Lymphatic Filariasis. This highlights Albendazole sulfone as a potential new treatment for neglected disease as well as a starting point for developing a new class of anti-Wolbachia compounds

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Abstract

Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.

Description

RELATION TO OTHER APPLICATIONS[0001]This application claims priority to and the benefit of U.S. provisional application No. 61 / 553,214 filed 30 Oct. 2011 which is hereby incorporated by reference for all purposes.FIELD OF THE INVENTION[0002]The invention relates novel uses of drugs for treating filarial disease.BACKGROUND[0003]Wolbachia are obligate-intracellular, maternally transmitted bacteria. Antihelminthic drugs have been widely used to combat Lymphatic Filariasis and African River Blindness. A significant drawback of antihelminthic therapies currently used to treat River Blindness and Lymphatic filariasis is that they simultaneously target other nematode infections as well. This is a particular problem in areas where people are co-infected with Loa Loa and either O. volvulus or B. malayi. In effort to identify new anti-Wolbachia therapeutics, we developed a Wolbachia-infected Drosophila cell line and conducted a high-throughput screen to identify compounds that reduced intrace...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4184A61K31/65A61K31/428A61K31/404A61K31/429
CPCA61K31/4184A61K31/65A61K31/429A61K31/404A61K31/428Y02A50/30A61K2300/00
Inventor SERBUS, LAURALANDMANN, FREDRICLINDLEY, CATHARINAWHITE, PAMELASULLIVAN, WILLIAM
Owner RGT UNIV OF CALIFORNIA
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