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Application of alpha-bromocinnamyl aldehyde in prevention and treatment of bacterial infectious diseases

A technology of bromocinnamaldehyde and bacterial infection, applied in antibacterial drugs, resistance to vector-borne diseases, active ingredients of aldehydes, etc., can solve the problem of unclear antibacterial spectrum and antibacterial mechanism, difficulty in screening bacterial infectious diseases, and no research Reported the effect of α-bromocinnamaldehyde and other issues, achieved significant antibacterial effect, good antibacterial activity, and improved protective effect

Inactive Publication Date: 2021-05-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

However, the lipid bilayer outer membrane structure of bacteria can prevent the penetration of various substances, making it difficult to screen for FtsZ protein targeting molecules that can be actually used in bacterial infectious diseases based on the inhibitory activity of FtsZ protein
α-Bromocinnamaldehyde (BCA) is often used in anti-mold, antibacterial, deodorizing and other aspects of articles. However, its antibacterial spectrum and antibacterial mechanism are still unclear, and there is no research report on α-Bromocinnamaldehyde in the treatment of bacterial infections in vivo. role in disease

Method used

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  • Application of alpha-bromocinnamyl aldehyde in prevention and treatment of bacterial infectious diseases
  • Application of alpha-bromocinnamyl aldehyde in prevention and treatment of bacterial infectious diseases
  • Application of alpha-bromocinnamyl aldehyde in prevention and treatment of bacterial infectious diseases

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Embodiment Construction

[0024] The present invention will be described in further detail below in conjunction with the accompanying drawings and examples. The examples are explanations of the present invention, rather than limiting the protection scope of the present invention.

[0025] 1. Evaluation of antibacterial activity of α-bromocinnamaldehyde in vitro

[0026] 1.1 Determination of minimum inhibitory concentration (MIC): The MIC of α-bromocinnamaldehyde on 6 strains of Gram-negative bacteria and 6 strains of Gram-positive bacteria was determined by microbroth dilution method. Take a sterile 96-well plate, add 100 μL of MHB medium to each well, and pipette 100 μL of antibacterial drug solution (including α-bromocinnamaldehyde, cinnamaldehyde, ampicillin, ceftazidime and ciprofloxacin) with a concentration of 1024 μg / mL to each well. In the first well, the concentration of antimicrobial drugs was adjusted to 256, 128, 64, 32, 16, 8, 4, 2, 1, 0.5, 0.25 and 0.125 μg / mL by serial dilution. Incubat...

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Abstract

The invention discloses an application of alpha-bromocinnamyl aldehyde in prevention and treatment of bacterial infectious diseases, the alpha-bromocinnamyl aldehyde can inhibit FtsZ protein polymerization and interfere normal division of bacteria, and the alpha-bromocinnamyl aldehyde shows broad-spectrum antibacterial activity to gram-positive bacteria and gram-negative bacteria. In a mouse multidrug resistance bacteria abdominal cavity infection model, the alpha-bromocinnamyl aldehyde can significantly improve the survival rate of infected animals, and has the characteristics of safety and low toxicity, which indicates that the alpha-bromocinnamyl aldehyde has good antibacterial activity, and can be used as a leading drug for treating bacterial infectious diseases.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of bacterial infectious diseases, and relates to the application of α-bromocinnamaldehyde in the prevention and treatment of bacterial infectious diseases. Background technique [0002] Bacterial infection is one of the most important diseases threatening human health, with more than 10 million deaths due to infection every year, and the spread of multidrug-resistant bacteria greatly limits the effectiveness of clinical antimicrobial treatment. [0003] FtsZ protein is a key molecule of bacterial division, widely distributed and highly homologous in various bacteria. In the non-proliferating state of bacteria, the FtsZ protein is scattered in the cytoplasm in the form of monomers and oligomers; when the bacteria enter the division stage, the FtsZ protein aggregates to form protofilaments, and participates in the formation of division complexes in the middle of the bacteria, mediat...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/11A61P31/04
CPCA61K31/11A61P31/04Y02A50/30
Inventor 侯征方超王明智马波薛小燕贾敏周珊
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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