8results about How to "Highly toxic" patented technology

The utility model relates to a water-soluble hexavalent chromium filtering and collecting device, which belongs to the field of laboratory collection, and comprises a Buchner funnel (1) and a tray (2), the Buchner funnel (1) comprises a funnel opening (3) and a funnel neck (4), the funnel neck (4) is arranged at the bottom of the funnel opening (3), the funnel neck (4) is connected with the tray (2), the Buchner funnel (1) is taken out, and a beaker (11) filled with filtrate is taken out at the same time. The Buchner funnel (1) is provided with a suction filtration bottle (5), the suction filtration bottle (5) is provided with an extraction opening (6), the extraction opening (6) is connected with an extraction pipe (7), the extraction pipe (7) is connected with the suction filtration bottle (5), and the suction filtration bottle (5) is connected with the suction filtration bottle (5). The exhaust pipe (7) is connected with a vacuum pump (8), so that the filtering effect is improved, and the filtering is faster.

The invention belongs to the field of microbial fermentation and the technical field of daily chemicals, and particularly relates to deacetylated sophorolipid as well as a preparation method and application thereof. By using cheap culture medium components and screening out saccharomycetes with high yield of lactone type sophorolipid, the problem that the production cost of the sophorolipid is too high is effectively solved, and the application of the sophorolipid in various fields is promoted; through the step of carrying out enzymolysis on a fermentation substrate in advance, the problems of long single fermentation period, low thallus utilization rate, high energy consumption and high cost of traditional saccharomycetes are solved. A multi-round fermentation circulation system is designed, and bacteria liquid is settled and recycled and then inoculated and fermented, so that thalli are efficiently and repeatedly utilized, the unit yield is increased, the fermentation period is shortened, and the production cost is effectively controlled. The structure is adjusted through a resin modification technology, a final product mainly comprises acetylated sophorolipid, and compared with acetylated sophorolipid and deacetylated sophorolipid, the sophorolipid has better foam stability and sensitive skin repairing effect and is suitable for the application fields of cosmetics, washing care and the like.

The invention discloses an exosome composition containing resveratrol, astragalus membranaceus and ginseng as well as a preparation method and application of the exosome composition, and belongs to the technical field of biological medicines. The exosome composition disclosed by the invention is obtained by inducing alveolar epithelial cells by active ingredients containing resveratrol, an astragalus extract and a ginseng extract and then secreting the alveolar epithelial cells. The preparation method of the exosome composition mainly comprises the following steps: co-culturing the active component and alveolar epithelial cells, and then sequentially carrying out differential centrifugation and ultracentrifugation on the collected cell supernatant to purify the exosome. The invention also provides a pharmaceutical preparation containing the exosome composition. According to the composition, traditional Chinese medicine active ingredients are combined with a modern cell exosome technology, a potential strategy is provided for prevention and treatment of pulmonary fibrosis, and the composition has a good application prospect.

This invention discloses the application of NADK inhibitors in the preparation of drugs for treating liver cancer, such as siRNA targeting NADK. This invention demonstrates that NADK inhibitors can be used to treat liver cancer, and the siRNA provided by this invention exhibits stronger cytotoxicity against HepG2 cells compared to previously disclosed NADK target sequences, effectively inhibiting the proliferation of liver cancer cells both in vitro and in vivo, achieving a tumor-suppressive effect. Furthermore, the siRNA designed in this invention can simultaneously knock down the mRNA levels of both human and mouse NADK genes, facilitating scientific research and the development of tumor drugs.

The invention relates to lactobacillus rhamnosus KXW1 with a hypoglycemic function and application of the lactobacillus rhamnosus KXW1, and belongs to the technical field of microorganisms. In order to excavate a microecological preparation for treating hyperglycemia-related diseases, a strain of lactobacillus rhamnosus KXW1 is separated, and in-vivo and in-vitro experiments prove that the strain has remarkable blood sugar reducing capacity, including promoting proliferation of high-glucose-induced INS-1 cells and increasing the relative expression quantity of MafA genes in the high-glucose-induced INS-1 cells, so that the hyperglycemia-related diseases can be treated. The fasting blood glucose level, postprandial blood glucose level, insulin resistance level, glycosylated hemoglobin level, liver copper ion level and the expression level of copper death related genes FDX1 and DLAT in the liver of the type II diabetes mellitus patient are reduced, and the oral glucose tolerance of the type II diabetes mellitus patient is enhanced. The strain KXW1 provided by the invention can be used for preparing medicines for reducing blood sugar and preventing and / or treating diabetes mellitus or health-care foods for assisting in reducing blood sugar, and opens up a new way for preventing and treating diabetes mellitus.

The application belongs to the technical field of biology, and particularly relates to a bacillus cereus for preventing and treating root-knot nematode and application thereof. The bacillus cereus is named as bacillus cereus ZWL-B-24, is preserved in Guangdong Microbial Culture Collection Center (GDMCC) with an address of 5th floor, building 59, Guangdong Academy of Microbiology, 100, Middle Junli Street, Guangzhou, and a preservation number of GDMCC No: 63680, and a preservation time of July 24, 2023. The bacillus cereus obtained in the application is derived from sweet potato soil, has a strong soil colonization capacity, and due to a long-term coexistence with sweet potato root systems, mutual symbiosis, a series of similar survival mechanisms are formed, and the bacillus cereus is applied to the prevention and treatment of sweet potato root-knot nematode disease, and is more safe and reliable for the growth, edible and processing products of sweet potato.

The application relates to the technical field of anti-counterfeiting materials, in particular to a bio-based anti-counterfeiting filter paper and a preparation method thereof. The application provides a bio-based anti-counterfeiting filter paper which comprises a base material and an anti-counterfeiting dye layer compounded on the base material; the anti-counterfeiting dye layer is prepared from anti-counterfeiting dyes; the anti-counterfeiting dyes are prepared from raw materials including isocyanate, polyethylene glycol, 2,2-dimethylol propionic acid, ethylenediamine and hematoxylin. The bio-based anti-counterfeiting filter paper provided by the application is doped with special anti-counterfeiting dyes, provides unique spectral reflection information, and has the advantages of being difficult to replicate, non-toxic and long service life. Compared with the anti-counterfeiting filter paper currently in circulation, the bio-based anti-counterfeiting filter paper provided by the application can reduce the inflow of fake and inferior products into the market, reduce the use risk of customers, and protect the legal rights and interests of customers.

The invention discloses composite paclitaxel albumin nanoparticles as well as a preparation method and application thereof, paclitaxel and a non-nucleotide interferon gene stimulating factor agonist are co-loaded by human serum albumin in a simple manner to form nanoparticles which are uniform in size, proper in particle size, relatively good in dispersity and stable in physicochemical property; the added non-nucleotide interferon gene stimulating factor agonist forms a dimer in a tumor acidic microenvironment, and active targeting of the carrier is combined, so that the nanoparticles have excellent selectivity on tumor tissues; a non-nucleotide interferon gene stimulating factor agonist starts congenital immunity and is combined with adaptive immunity of paclitaxel, so that the defect of low immune responsiveness of'cold 'tumors is overcome. In-vivo and in-vitro toxicity experiments prove that the nanoparticles provided by the invention can solve the problem of strong toxic and side effects of paclitaxel and have synergistic effects on anti-tumor immunotherapy of paclitaxel at the same time, so that the effect of combined treatment is achieved.