Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver

A technology of polyvinyl alcohol sponge and polyvinyl alcohol, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of high efficiency, wide size distribution, and large particle size that affect antibacterial performance, and achieve the promotion of wound healing and high porosity , the effect of dense and uniform voids

Inactive Publication Date: 2010-12-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nano-silver materials prepared by traditional methods have large particle sizes and wide size distributions, which affect the high efficiency of their antibacterial properties.

Method used

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  • Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver
  • Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver
  • Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Slowly dissolve 400 mg of silver nitrate in 50 ml of polyethylene glycol (molecular weight 400 g / mol) solution. Under light-shielding conditions, the mixture was stirred for 2 hours, and the color of the solution changed from light yellow to orange-red to obtain a nano-silver / polyethylene glycol solution.

[0028] Dissolve 0.05g of chitosan in 5% volume fraction of dilute acetic acid aqueous solution to prepare a 1.0% mass fraction of chitosan solution. Dissolve 0.05 g of polyvinyl alcohol in 5 ml of boiling water to prepare a 1.0% polyvinyl alcohol solution. The above chitosan solution and polyvinyl alcohol solution are mixed at a volume ratio of 1:1 and then fully stirred to obtain a chitosan / polyvinyl alcohol blend. Weigh 20g of polyvinyl alcohol, dissolve it in 200mL of boiling water, cool down to 50°C, add 0.20g of sodium lauryl sulfate, 22mL of formaldehyde with a mass fraction of 37% and 2.0g of sodium bicarbonate, and stir at 1500r / min for 20min , keep at 50°C...

Embodiment 2

[0032] Slowly dissolve 300 mg of silver nitrate in 40 ml of polyethylene glycol (molecular weight: 400 g / mol) solution at room temperature 25°C. Under the condition of avoiding light, react under stirring for 6 hours, the color of the solution changes from light yellow to orange red, and a nano-silver / polyethylene glycol solution is obtained.

[0033]Dissolve 0.05g of chitosan in 5% dilute acetic acid aqueous solution to prepare a chitosan solution with a mass fraction of 1.0%. Dissolve 0.05 g of polyvinyl alcohol in 5 ml of boiling water to prepare a 1.0% polyvinyl alcohol solution. The above chitosan solution and polyvinyl alcohol solution are mixed at a volume ratio of 1:1 and then fully stirred to obtain a polyvinyl alcohol / chitosan blend. Weigh 20g of polyvinyl alcohol, dissolve it in 120mL of boiling water, cool down to 35°C, add 0.10g of sodium lauryl sulfate, 20mL of formaldehyde with a mass fraction of 37% and 3.0g of sodium bicarbonate, and stir at 1500r / min for 20m...

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Abstract

The invention discloses a preparation method of a chitosan/polyvinyl alcohol sponge dressing containing nano-silver. The invention relates to an antibacterial dressing for therapy of trauma, and the chitosan/polyvinyl alcohol sponge dressing containing the nano-silver is prepared by adding nano-silver/polyvinyl alcohol solution and polyvinyl alcohol/chitosan blend solution. The obtained dressing has good biocompatibility and hemostatic and antibacterial effects, and can promote the wound healing; the product can accelerate the wound healing, release nano-silver particles in a sustained manner, be acted on regenerated bacteria constantly, have the lasting and high-efficient sterilization characteristics and avoid the drug resistance during the wound treatment process; the research on the toxic effect of the material to mouse fibroblasts shows that the product has no obvious toxicity to the cells and has the effect of promoting the growth of the cells; and preparation method has simple process equipment and low price of experimental raw materials and is conductive to industrialization.

Description

technical field [0001] The invention relates to an antibacterial dressing for wound treatment, in particular to a preparation method of a nanosilver-containing chitosan / polyvinyl alcohol sponge dressing. Background technique [0002] A medical dressing is a protective covering over a wound to help control bleeding, prevent infection, and absorb secretions. Modern medical biological dressings are new types of wound repair and protection materials developed on the basis of the "moist healing" theory of wound repair by Winter and Hinman. Compared with traditional medical dressings (such as absorbent cotton yarn), modern medical biological dressings have accelerated wound healing. Healing, avoiding wound adhesion, promoting tissue repair, antibacterial and anti-inflammatory and other characteristics. In the treatment of burns, the use of antibacterial dressings containing antibacterial drugs is still one of the important measures to prevent invasive infection of wounds. A good...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/18A61L15/44C08L5/08C08L29/14C08K3/08C08J9/08C08F16/38
Inventor 魏坤曾晓峰
Owner SOUTH CHINA UNIV OF TECH
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