Application of salvianolic acid B and analogues of salvianolic acid B in preparing anti-HPV-viral-infection medicine

Abstract

The invention discloses application and salvianolic acid B and analogues of the salvianolic acid B in preparing anti-HPV-viral-infection medicine, and belongs to the field of biomedicine. The inventordiscovers that the salvianolic acid B and the analogues, such as myricetin and dihydromyricetin, of the salvianolic acid B for the first time through researches, the salvianolic acid b and the analogues of the salvianolic acid B have good anti-HPV-viral-infection activity and can effectively block adhering of HPV viruses to target cells, and then HPV viral infection is inhibited. Experiments prove that the salvianolic acid B and capsid protein of the viruses can be directly bound, and adhesion of antagonism viruses to the target cells achieves an anti-virus effect. The salvianolic acid B actsin the early stage that the viruses enter the cells, and can also act in the middle stage and the later stage that the viruses enter the cells. The effects are better than medicine only acting on theearly stage that the viruses enter the cells in the prior art. The salvianolic acid B is harmless to the human body in a concentration range where the salvianolic acid B can achieve the anti-virus function. It is very likely that the salvianolic acid B is developed into a novel microbicide for preventing and treating HPV and other sexually transmitted viral infection.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of salvianolic acid B and its structural analogues in the preparation of anti-HPV virus infection drugs. Background technique [0002] Human papillomavirus (human papillomavirus, HPV) is a kind of epitheliophilic virus, belonging to papillomavirus genus of Papovaviridae, is a kind of non-enveloped double-stranded circular epitheliophilic DNA with small molecular weight (7.9Kb) Virus. There are currently about 200 different subtypes of HPV, which are divided into low-risk and high-risk types according to their pathogenicity. Low-risk HPVs mainly cause low-grade lesions at the site of infection, genital or skin warts, and condyloma acuminatum, while high-risk HPVs mainly cause high-grade lesions at the site of infection and invasive cancer. At the same time, the persistent infection of high-risk HPV has been proved to be an important risk factor for the indu...

AI Technical Summary

Problems solved by technology

Although RNA interference (RNAi) nucleotide analogs can interfere with the expression of HPV virus-related genes to achieve antiviral effects, they only work at the post-transcriptional level and have no impact on the incubation period of the virus. Therefore, RNAi nucleosides Acid analogs cannot be used alone in the treatment of HPV-related diseases

In addition, antioxidants and herbal derivatives have also shown effective therapeutic potential for HPV infection, and the research results of herbal derivatives are the most notable, such as Berberine, Curcumin, Norda Hydrogen Generic acid (NGDA), EGCG, etc., these herbal derivatives can partially inhibit the diseases caused by HPV infection by blocking the transcription of viral genes or antagonizing the function of viral proteins, but these drugs have shown high antiviral efficacy in the research and development stage. effect, but it is forbidden for pregnant women. In addition, the above-mentioned drugs were shelved due to safety and effectiveness issues when they were used in clinical research, resulting in the failure of research and development

[0006] At the same time, a group of antimicrobial candidate drugs, such as Praneem, Carrageenan, curcumin polymeric herbal preparation Basant and JB01-BD, can prevent HPV infection by blocking HPV virus from invading human cells effect, but again, their role is limited to the prevention of HPV infection, and cannot be treated in the case of HPV infection

It is speculated that it may be because the above candidate drugs mainly work before the virus invades the cells, and the effect is not good after the virus invades the cells and reproduces in large numbers

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