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44results about How to "Guaranteed industrial production" patented technology

Production of high-performance polyisoprene water latex, its gloves and related products

ActiveCN101029163AEmulsion polymerization process is stableImprove conversion rateMale contraceptivesGlovesSynthetic polymerEmulsion
Production of polyisoprene water latex, its gloves and related products is carried out by polymerization reacting for isoprene monomer, emulsifying agent and evocating agent by emulsion free-radical at normal-temperature and pressure or mixing polyisoprene water latex with other synthetic polymer. It has excellent strength and extensibility.
Owner:SHANGHAI SHENGDA ENTERPRISE +1

Spinning-grade polyoxymethylene material and preparation method thereof

The invention discloses a spinning-grade polyoxymethylene material and a preparation method thereof. The spinning-grade polyoxymethylene material is prepared from the following raw materials by melt extrusion: 100 parts by weight of polyoxymethylene resin polymer, 0.01-3 parts of an anti-oxidant, 0.01-7 parts of a formaldehyde absorbent and 0.05-5 parts of a lubricant. By adding auxiliary agent capable of performing combined action with the base material into the base material and optimizing and adjusting the ratio parameters of the formula, the polyoxymethylene product has good dispersibility and fluidity, the spinnability of the material is substantially improved in spinning process, and the strength / elasticity modulus of the fiber are substantially improved, so that the industrialized production of the spinning-grade polyoxymethylene material is guaranteed. Also, under the condition of optimizing and adjusting different ratios of polymerization monomers of the polyoxymethylene resin, by employing conventional production technology, the polyoxymethylene material has appropriate melt index, the crystallization of the fiber-grade polyoxymethylene resin can be effectively controlled, high-strength fiber products can be produced, and the production technology is simple and easy to operate, and compared with prior art, the cost is relatively low and the production efficiency is relatively high.
Owner:YUNNAN YUNTIANHUA

Application of tanshinone óÄA in pharmacy

The invention relates to the use of tanshinone IIA in the preparation of medicaments for treating atherosclerosis, myocardial infarction, coronary heart disease, tumor, purulency osteomyelitis and tonsillitis. The tanshinone IIA of the invention can be prepared into various dosage types.
Owner:昆明希捷医药研发有限公司

Electronic shift device

The invention relates to an electronic shift device, comprising a servo motor, a locomotory apparatus and a shift straining ring, wherein the locomotory apparatus comprises a main locomotory apparatus and an assistant locomotory apparatus, and the servo motor is fixedly installed on the main locomotory apparatus; the main locomotory apparatus comprises a guide holder, a connecting flange, a ball screw, a ball nut and a propeller shaft, wherein the connecting flange is fixedly installed on one end of the guide holder to be connected with the servo motor; the shift staining ring is positioned on the other end of the guide holder; the propeller shaft is positioned in the guide holder, one end of the propeller shaft is fixed with the shift straining ring, and a cavity is formed in the other end of the propeller shaft; the ball screw and the ball nut are fixed in the cavity; and the ball screw is connected with the connecting flange by a screw shaft on the end of the ball screw. The assistant locomotory apparatus comprises a spring shaft, a transition shaft, a linear bearing and an assistant straining ring, wherein one end of the spring shaft is fixed with the shift straining ring, the other end of the spring shaft is fixedly arranged on the assistant straining ring, and the transition shaft is installed in the guide holder by the linear bearing. The invention is favorable for ensuring product quality and maintenance, prevents dust from entering, has low cost, and simple and compact structure and improves the service life of products.
Owner:CHANGZHOU WUJIN WUYANG TEXTILE MACHINERY

Extract of yangtao actinidia root and preparation method and applications thereof

The invention discloses an extract of yangtao actinidia root and a preparation method and applications thereof. The extract of yangtao actinidia root, which is provided by the invention, is prepared by the following method: using water and / or an organic solvent as an extractant to extract the extract of yangtao actinidia root from yangtao actinidia root. Experiment shows that the extract of yangtao actinidia root can effectively inhibit the activity of fatty acid synthase. The inhibition kinetic analysis shows that the inhibition of the extract of yangtao actinidia root for the fatty acid synthase and the substrates of acetylcoenzyme A and NADPH have a competitive and non-competitive mixed type relationship, but more close to the non-competitive relationship; and the inhibition of the extract of yangtao actinidia root for the fatty acid synthase and the substrate of malonyl coenzyme A have a competitive and non-competitive mixed type relationship. The extract of yangtao actinidia root can be applied to the preparation of weight-reducing medicament and the medicament for preventing and treating cancers, and also can be widely applied as food, health product and daily chemical additive.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES

Method used for extracting burdock fructose oligosaccharides from burdock root

The invention provides a method used for extracting burdock fructose oligosaccharides from burdock root. The method mainly comprises following steps: processed burdock root is subjected to high intensity pulsed electric field extraction; an obtained extract is subjected to centrifugation precipitation so as to obtain a supernate; the supernate is subjected to secondary ultrafiltration membrane filtration so as to obtain a burdock fructose oligosaccharide concentrated solution; and the burdock fructose oligosaccharide concentrated solution is subjected to drying so as to obtain burdock fructose oligosaccharides with uniform molecular weight.
Owner:博德生物技术(德州)有限公司

Polymer composite material containing micro-nano hybrid structure filler, and preparation method thereof

The invention discloses a polymer composite material containing a micro-nano hybrid structure filler, and a preparation method thereof, wherein the composite material is composed of graphene nanosheets, magnesium salt whiskers and a polymer matrix. According to the invention, a stable, perfect and efficient heat-conducting network chain is constructed in a polymer matrix by adopting an organic-inorganic hybrid composed of multi-scale and multi-dimensional graphene nanosheets and magnesium salt whiskers, so that the heat-conducting property of the composite material is greatly improved under the condition of low filler addition amount while good melt processability is ensured; the hybrid structure filler also has good reinforcing and toughening effects on the composite material, and significantly improves the comprehensive mechanical properties of the composite material; and the method is simple in production process, easy to implement, rich in raw material source, safe, environment-friendly and low in production cost.
Owner:ENN GRAPHENE TECH CO LTD

Application of germacrone in preparation of liver cancer treatment medicines

The invention provides an application of germacrone as a liver cancer treatment medicine. Results of experiments about the cytotoxicity of germacrone to HepG2 cells show that IC50 is about 160mum; and results of experiments about the detection of the influences of germacrone to liver cancer HepG2 cell cycle and apoptosis by using a flow cytometer show that germacrone can induce HepG2 cell G2 / M cycle arrest and promote the cell apoptosis. Results of the detection of the cycle arrest and the apoptosis related protein expression situation by processing HepG2 cells through different concentrations of germacrone show that germacrone induces the HepG2 cell G2 / M cycle arrest by reducing the cyclinB1 and CDK1 proteins and promotes the HepG2 cell apoptosis through p53 regulated mitochondrial apoptosis. Results of the detection of the ROS output of the germacrone processed HepG2 cells show that germacrone can promote the rise of the ROS output and cause the oxidative damages of the cells.
Owner:HUAZHONG UNIV OF SCI & TECH

Perovskite type solar cell based on multi-orientation ordered crystallization and preparation method thereof

The invention discloses a perovskite type solar cell based on multi-orientation ordered crystallization and a preparation method thereof. The preparation method comprises the steps that: step 1, methylammonium iodate, lead chloride, indium chloride or indium iodide dissolves in a N,N-dimethylformamide solution to obtain a perovskite type DMF solution; step 2, an electrode is processed by a poly (3,4-ethylenedioxythiophene) : polystyrene sulfonic acid salline solution to form an anode decoration layer; step 3, annealing is carried out on a thin film to form an anode decoration layer; step 4, the perovskite type thin film is processed and then is treated by annealing to obtain a photosensitive layer; step 5, a methyl [6,6]-phenyl-C61-butyrate (PCBM) thin film is processed to obtain an electron transfer layer; step 6, a 1,10-phenanthronline,4,7-diphenyl (Bphen) thin film is continuously processed to obtain a cathode decoration layer; and step 7, a cathode electrode is processed. With the prepared solar cell, the energy conversion efficiency of the device and the device stability are improved obviously.
Owner:SUZHOU UNIV

Closing edge capable of adjusting allowance of decoration panel and application thereof

The invention provides a closing edge capable of adjusting the allowance of a decoration panel and application thereof and belongs to the technical field of architectural decoration. The closing edge comprises a wall surface mounting U-shaped piece and a top surface mounting U-shaped piece, wherein the wall surface mounting U-shaped piece is used for being mounted on a wall surface; the top surface mounting U-shaped piece is mounted at the top of a wall; the wall surface mounting U-shaped piece is composed of four wall surface connecting edges which are vertically connected end to end sequentially; the top surface mounting U-shaped piece is composed of five top surface connecting edges which are vertically connected end to end sequentially; and a C-shaped covering keel is connected with one end of a hanging type closing edge keel in a fastening way. The obtained closing edge capable of adjusting the allowance of the decoration panel can guarantee industrial production of top plates; when the last top plate of a suspended ceiling plate is quickly mounted in the field, the residual allowance of the plate can be adjusted; the component guarantees the aesthetic property of modeling at the closing edge of the wall top of a suspended ceiling; and the obtained closing edge can be used for a hem of the wall top and also can be used for decoration of the closing edge at a curtain box and the closing edge at a lay-in suspended ceiling inside corner, so that the operability is improved, and the closing edge provided by the invention is applicable to popularization and application.
Owner:ZHEJIANG YASHA DECORATION

Shogging mechanism

The invention relates to a traverser of guide bar, consisting of a service motor and a locomotory apparatus. The locomotory apparatus consists of a main locomotory apparatus and an auxiliary locomotory apparatus; the auxiliary locomotory apparatus is fixed on the outer side of the main locomotory apparatus in a parallel way; the service motor is positioned on a bearing seat of the main locomotory apparatus; a retractable shaft of the auxiliary locomotory apparatus is fixedly connected with a pushing rod shaft of the main locomotory apparatus through a connecting rod. As the pushing rod shaft and a ball screw are on the same axis and the auxiliary locomotory apparatus is arranged on one side of the pushing rod shaft and connected with the pushing rod shaft through the connecting rod, the torsion on the pushing rod shaft is removed by the retractable shaft and is no longer output, and the traversing error of the pushing rod shaft is reduced due to diminished gap between the ball screw and a ball nut, thereby improving the precision and lengthening the service life of the traverser; meanwhile, the ball nut and the ball screw are arranged in a sealed sleeve, which is not only good for ensuring product quality but also good for maintaining and preventing dust from entering, further with the advantages of low cost, simple and compact structure, etc.
Owner:王占洪

Automatic discharging system and discharging method of heat exchanger plate pieces

The invention provides an automatic discharging system and method of heat exchanger plate pieces. The system comprises a stainless steel uncoiling device, a stainless steel coil flat plate device anda laser cutting device in sequence; an automatic stacking machine is arranged above the laser cutting device, the stainless steel uncoiling device is used for uncoiling the stainless steel coil, meanwhile, isolation paper on the stainless steel coil is coiled up, the stainless steel coil flat plate device is used for leveling the uncoiled stainless steel coil, the laser cutting device is used forcarrying out laser cutting on the leveled stainless steel coil, and the heat exchanger plate pieces are formed; the automatic stacking machine is used for stacking the heat exchanger plate pieces. Through automatic uncoiling, automatic leveling, automatic laser cutting and automatic stacking of the stainless steel plate pieces, intelligent production of the heat exchanger plate pieces can be achieved, traditional old processes of plate shearing machines, punching machines and punching molds are replaced, and production efficiency and precision are improved.
Owner:辽宁光阳换热设备制造有限公司

Application of 2,6-bis(2-benzimidazolyl) pyridine in preparation of carbapenem-resistant pseudomonas aeruginosa infection drug

The invention discloses application of 2,6-bis(2-benzimidazolyl) pyridine in preparation of a carbapenem-resistant pseudomonas aeruginosa infection drug. Through circular dichroism, fluorescent real-time quantitative PCR and other methods, it is found that 2, 6-bis (2-benzimidazolyl) pyridine can form a G-quadruplex structure with a core sequence of a MexA gene in pseudomonas aeruginosa, thereby inhibiting expression of the MexA gene. A susceptibility testing verifies that 2, 6-bis (2-benzimidazolyl) pyridine can reduce the drug resistance of carbapenem-resistant pseudomonas aeruginosa to meropenem. When the usage amount of the 2, 6-bis (2-benzimidazolyl) pyridine is 5 <mu>M, the minimum inhibitory concentration of the carbapenem-resistant pseudomonas aeruginosa strain can be reduced to 2<mu> g / ml, and the effect of treating carbapenem-resistant pseudomonas aeruginosa infection by using meropenem is achieved.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Adjustable pipeline measuring control device capable of using electromagnetic induction principle

The invention relates to the technical field of pipeline instrument detection, and discloses an adjustable pipeline measuring control device capable of using an electromagnetic induction principle. The device comprises a pipeline, a plunger rod is in sliding connection into the pipeline, the top of the plunger rod is fixedly connected with a first electromagnet, the bottom of the first electromagnet is fixedly connected with a first spring, the outer portion of the first spring is movably connected with a controller, the interior of the controller is fixedly connected with a second electromagnet, the outer portion of the pipeline is fixedly connected with a floating cylinder, a floating block is movably connected into the floating cylinder, and through cooperative use of the plunger rod, the first electromagnet, the second electromagnet, the floating block, a push rod, a sliding rod and a resistance block, the effect of automatically controlling the flow in the pipeline can be achieved, it is ensured that the flow in the pipeline is constant, measuring is facilitated, measuring result accuracy is ensured, it is ensured that the flow in the pipeline is stable, the equipment cost islow, and industrial production is ensured.
Owner:LINGSHENGCHENG TECH JIANGSU CO LTD

Superconducting magnetic separation method for realizing continuous ore feeding and separation by using swivel structure

The invention discloses a superconducting magnetic separation method for realizing continuous ore feeding and separation by applying a swivel structure. According to the method, continuous ore feedingand sorting are achieved by controlling a swivel medium box containing a plurality of sorting cavities to do circulating rotary motion in a superconducting magnet magnetic field which is horizontallyarranged, and the swivel medium box moves along an annular track to do circulating rotary motion in the superconducting magnet magnetic field. According to the method provided by the invention, restrictions of a solenoid superconducting magnet structure on feeding and sorting modes of a separation system are overcome; continuous ore feeding (uninterrupted ore feeding) and continuous separation (uninterrupted concentrate collection and tailing collection) of a superconducting magnetic separator are achieved through the swivel type structure; the equipment treatment amount is remarkably increased; the method is used for the magnetic separation operation process of non-metal ore and metal ore; blockage is avoided, and valve abrasion is reduced; and continuous industrial production of the superconducting magnetic separator is guaranteed.
Owner:江苏旌凯中科超导高技术有限公司

Mushroom and duck soup with low sodium salt content and industrial preparation method thereof

The invention discloses mushroom and duck soup with low sodium salt content and an industrial preparation method thereof. According to the method, the mushroom and duck soup is obtained by treating soup-stock, a Jingzhou local shelduck and mushrooms respectively, and then carrying out compounding and mixing treatment on the soup-stock, a duck meat loaf, the mushrooms, NaCl, KCl, pepper and I+G (Disodiuminosine 5'-monophosphate and Disodiumguanosine 5'-monophosphate), and carrying out packaging and high-temperature and high-pressure sterilization on an obtained mixture. The content of sodium in every working procedure is detected by using a sodium ion meter; the on-line monitoring on a sodium ion is realized; the sodium salt content is enabled to meet a requirement set for a product; the problem that the content of the sodium ion in a raw material at different production origins and in different batches is different is solved; the range of the content of the sodium ion from the raw material and an auxiliary material to a final finished product process is enabled to be precise and controllable. A prepared duck soup product has distinct characteristics in flavor and taste, is rich in nutrient, low in sodium element content and high in potassium element content, and meets the demands of a modern person on healthy diet.
Owner:WUHAN POLYTECHNIC UNIVERSITY

Application of 3,5-di-tert-butyl copper salicylate to preparing drug for treating high-metastatic breast cancer

The invention discloses application of 3,5-di-tert-butyl copper salicylate to preparing drug for treating high-metastatic breast cancer and administration dosage of 3,5-di-tert-butyl copper salicylate. Experiments prove that 3,5-di-tert-butyl copper salicylate can inhibit transfer of breast cancer cells, and breast cancer cell invasion is inhibited through concentration dependence. New medical application of 3,5-di-tert-butyl copper salicylate is developed, and a new application field is exploited.
Owner:JIANGHAN UNIVERSITY

Potato-rich fine dried noodles based on three-layer composite calendering and preparation method thereof

The invention provides potato-rich fine dried noodles based on three-layer composite calendering and a preparation method thereof. The potato-rich fine dried noodles comprise the following raw materials in parts by weight: 20-40 parts of potato whole powder, 52.7-77 parts of wheat flour and 3-7.3 parts of vital gluten. The raw materials are premixed: the whole potato flour, the wheat flour and thevital gluten are divided into inner-layer flour and outer-layer flour, which are respectively and uniformly mixed; the inner-layer flour is mixed flour of whole potato flour, wheat flour and vital gluten, the outer-layer flour is wheat flour, and the mass ratio of the inner-layer flour to the outer-layer flour is 1: 0.5-1: 1.5; and the mass ratio of the whole potato flour to the wheat flour to the vital gluten in the inner-layer flour is (0.4-0.6): (0.29-0.54): (0.06-0.11). According to the potato-rich fine dried noodles, the technical problems that potato noodles are poor in tensile capacity, easy to stick to rollers, large in noodle cooking loss, easy to break, difficult in rolling and drying of inner-layer high-moisture sandwich noodles and the like are effectively solved, the potato-rich food fine dried noodles with excellent processing quality, eating quality and functional quality are produced, and the content of whole potato flour is 20%-40%.
Owner:KEMEN NOODLE MFG CO LTD

A method for extracting burdock polysaccharide from burdock root

The invention provides a method for extracting burdock fructo-oligosaccharides from burdock roots, which mainly includes: extracting the treated burdock root material with a high-voltage pulse electric field, extracting the supernatant through centrifugal precipitation, and passing the supernatant twice The burdock fructooligosaccharide concentrate is obtained by ultrafiltration membrane filtration, and finally the concentrate is dried to obtain burdock fructooligosaccharide with relatively uniform molecular weight.
Owner:博德生物技术(德州)有限公司

Pneumatic lifting mechanism for laser cutter for sheet bars of heat exchanger and control method for pneumatic lifting mechanism

PendingCN108555465ASolve the problem of scratching the support platformDisadvantages after optimizing the use of laser cutting machinesLaser beam welding apparatusHigh volume manufacturingEngineering
The invention discloses a pneumatic lifting mechanism for a laser cutter for sheet bars of a heat exchanger and a control method for the pneumatic lifting mechanism. The pneumatic lifting mechanism comprises a lifting platform which consists of a bracket and a plurality of lifting racks, a pneumatic bracket, slide wheel fixing parts, slide wheels and an air cylinder assembly, wherein the lifting platform is mounted on the bracket; the air cylinder assembly is mounted on a beam of the bracket below the lifting platform; the pneumatic bracket is mounted on an extending-out piston rod of the aircylinder assembly; the air cylinder assembly drives the pneumatic bracket to lift between the beam of the bracket and the lifting platform; a gap is formed between every two adjacent lifting racks inthe lifting platform; the slide wheels are uniformly distributed in the gap between every two adjacent lifting racks; the slide wheels are mounted on the slide wheel fixing parts through bearings or rotary shafts; and the slide wheel fixing parts are mounted on the pneumatic bracket. The pneumatic lifting mechanism has the advantages that the defect that laser cutter is used in a laser cutting production line for sheet bars of the heat exchanger is optimized, and guarantee is provided for large-scale production and industrial production.
Owner:辽宁光阳换热设备制造有限公司

Preparation method of compound

The invention provides a preparation method of a compound as described in the formula 1. The method comprises the steps of (1) contacting a compound as described in the formula 2 and a compound as described in the formula 3 in the existence of alkali to obtain a compound as described in the formula 4; and (2) directly contacting a reaction product obtained in the step (1) and paraformaldehyde to obtain the compound as described in the formula 1, wherein weak acid is added in the reaction product before the reaction product obtained in the step (1) is in contact with the paraformaldehyde so that the residual alkali in the reaction product can be neutralized. By using the method, the compound as described in the formula 1 can be effectively prepared.
Owner:湖北华世通生物医药科技有限公司

Preparation method for Huangjinya osmanthus-scented Congou black tea

The invention discloses a preparation method for Huangjinya osmanthus-scented Congou black tea, and relates to the technical field of black tea preparation. The preparation method comprises the following steps of S1, collection of fresh leaves, wherein pekoe fresh leaves are selected as raw materials, and the picking standard includes selection of single buds, early development of a bud and a leaf, completeness and tidiness of the buds and leaves, exclusion of no fish leaf or damaged leaf and the like; and S2, withering, the picked fresh leaves of the same level are conveyed to a factory, andspread and withered in time. According to the preparation method for the Huangjinya osmanthus-scented Congou black tea, the osmanthus-scented Congou black tea can be subjected to standard, precise andsanitary treatment, and standardized and industrialized production of products can be ensured; the products can be produced on a large scale in a centralized mode, and it is ensured that the productsare stable in quality and consistent in flavor; according to the preparation method, by adopting a cryogenic freezing-drying technology, the flavor of spring bud tea is ensured, and the fragrance ofosmanthus is further ensured effectively; and the high-quality spring tea and the osmanthus tragrans with best flavor are combined, and the product quality of the osmanthus-scented black tea is improved greatly.
Owner:成都巧匠农业有限公司

Application of 3,5-di-tert-butyl copper salicylate in the preparation of drugs for the treatment of highly metastatic breast cancer

The invention discloses the application of 3,5-di-tert-butyl copper salicylate in the preparation of medicines for treating highly metastatic breast cancer and the dosage of 3,5-di-tert-butyl copper salicylate. Experiments have proved that copper 3,5-di-tert-butyl salicylate can inhibit the metastasis of breast cancer cells, and inhibit the invasion of breast cancer cells in a concentration-dependent manner. The invention discovers a new medical application for 3,5-di-tert-butyl copper salicylate, and opens up a new application field.
Owner:JIANGHAN UNIVERSITY

Guide bar shogging mechanism

The invention relates to a traverser of guide bar, consisting of a service motor and a locomotory apparatus. The locomotory apparatus consists of a main locomotory apparatus and an auxiliary locomotory apparatus; the auxiliary locomotory apparatus is fixed on the outer side of the main locomotory apparatus in a parallel way; the service motor is positioned on a bearing seat of the main locomotoryapparatus; a retractable shaft of the auxiliary locomotory apparatus is fixedly connected with a pushing rod shaft of the main locomotory apparatus through a connecting rod. As the pushing rod shaft and a ball screw are on the same axis and the auxiliary locomotory apparatus is arranged on one side of the pushing rod shaft and connected with the pushing rod shaft through the connecting rod, the torsion on the pushing rod shaft is removed by the retractable shaft and is no longer output, and the traversing error of the pushing rod shaft is reduced due to diminished gap between the ball screw and a ball nut, thereby improving the precision and lengthening the service life of the traverser; meanwhile, the ball nut and the ball screw are arranged in a sealed sleeve, which is not only good forensuring product quality but also good for maintaining and preventing dust from entering, further with the advantages of low cost, simple and compact structure, etc.
Owner:王占洪

A device and process for washing crude glycine by alcohol phase method

The patent of the invention relates to the device and process for washing crude glycine by alcohol phase method. The glycine centrifuge is connected with the dilute methanol washing tank, and the dilute methanol washing tank is connected with the glycine extraction kettle through the dilute methanol pump; the glycine extraction kettle is connected with the extraction glycine centrifuge. ; The extraction glycine centrifuge is connected to the methanol rectification tower through the extract liquid transfer pump, and the methanol rectification tower is connected to the red ammonium concentration system. In the process, alcohol is used as a solvent, chloroacetic acid is used as an initial raw material, and crude glycine is produced by using mixed solvents or organic amines or new halogen-type formula reagents (the main content of glycine is 93% to 96%, and the content of chloride radicals is 2% to 4%, other impurities less than 1%), after the systematic industrial washing process, a glycine product that meets the glyphosate synthesis and national standards (main content ≥ 98.5%, chloride ≤ 0.4%) can be obtained without affecting The yield of glycine synthesis is high, and the waste water is completely reused in the system to achieve clean production.
Owner:HUBEI TAISHENG CHEM

Compound preparation method

The invention provides a preparation method of a compound as described in the formula 1. The method comprises the steps of (1) contacting a compound as described in the formula 2 and a compound as described in the formula 3 in the existence of alkali to obtain a compound as described in the formula 4; and (2) directly contacting a reaction product obtained in the step (1) and paraformaldehyde to obtain the compound as described in the formula 1, wherein weak acid is added in the reaction product before the reaction product obtained in the step (1) is in contact with the paraformaldehyde so that the residual alkali in the reaction product can be neutralized. By using the method, the compound as described in the formula 1 can be effectively prepared.
Owner:湖北华世通生物医药科技有限公司
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