Application of tanshinone óÄA in pharmacy

A technology for tanshinone and atherosclerosis, which is applied in the field of compound tanshinone IIA, can solve problems such as unreported uses, achieve sufficient extraction, strong pharmacological effects, and ensure industrial production

Inactive Publication Date: 2005-06-29
昆明希捷医药研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ester-soluble components of Salvia miltiorrhiza contain tanshinone IIA, cryptotanone and others. The extraction process of tanshinone IIA has been reported, but its use has not been reported, especially the use in pharmaceuticals has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Tanshinone IIA is extracted by known methods.

[0024] Dry 50 kg of boiled salvia miltiorrhiza (the same is true for unboiled raw medicinal materials), add 5 times the amount of 95% alcohol, reflux for 3 hours, filter, and repeat the operation once more, and concentrate the ethanol solution under reduced pressure for the first time To about 20 to 25 liters, the second and third reflux liquids were combined and concentrated under reduced pressure to the same volume, and left for about 15 hours respectively. The mother liquor continued to stand for about 15 hours to be analyzed. Filter out the precipitate, then concentrate the mother liquor under reduced pressure to 1 / 3 volume, and leave it for more than 10 hours, the crude product still precipitates, and repeat the operation until there is no precipitate, and place the mother liquor for extraction of other components of Danshen. Utilize thin-layer chromatography to identify the purity of each batch of crude tanshinone I...

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PUM

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Abstract

The invention relates to the use of tanshinone IIA in the preparation of medicaments for treating atherosclerosis, myocardial infarction, coronary heart disease, tumor, purulency osteomyelitis and tonsillitis. The tanshinone IIA of the invention can be prepared into various dosage types.

Description

technical field [0001] The present invention relates to a kind of compound Tanshinone IIA (molecular formula: C 19 h 18 o 3 ), especially in the pharmaceutical field. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant in the Labiatae family. It was first recorded in "Shen Nong's Materia Medica", and has been recorded in successive dynasties of herbal medicines. It is bitter in taste, slightly cold in nature, and enters the two meridians of Guixin and Liver. Tool dispelling blood stasis and relieving pain, promoting blood circulation to stimulate menstrual flow, clearing away heart-fire and eliminating troubles. Salvia miltiorrhiza is a traditional Chinese medicine for promoting blood circulation and removing blood stasis, and its commonly used preparations are mainly used to treat cardiovascular and cerebrovascular diseases. The chemical composition of Danshen is water-soluble phenolic acid and ester-solubl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P9/10A61P11/04A61P19/08A61P35/00
Inventor 秦引林颜培玲何龙其
Owner 昆明希捷医药研发有限公司
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