44results about How to "Reduce tendency to aggregate" patented technology

The invention relates to processes for the preparation of highly concentrated, liquid formulations comprising at least one anti-EGFR antibody and / or one of its variants and / or fragments, in particular monoclonal antibodies against the EGF receptor, particularly preferably of Mab C225 (cetuximab) and Mab h425 (EMD 72000), by ultrafiltration. The invention furthermore relates to highly concentrated, liquid formulations of anti-EGFR antibodies, in particular of monoclonal antibodies against the EGF receptor, particularly preferably Mab C225 (cetuximab) and Mab h425 (EMD 72000) and / or variants and / or fragments thereof, characterised in that the highly concentrated, liquid formulations have a content of anti-EGFR antibodies of 10-250, preferably 50-180 mg / ml, particularly preferably of 100-150 mg / ml, and to the use thereof.

The present invention relates to a new method for purifying acrylic acid. It uses tetrafluoroethylene single coboiling agent or tetrafluoroethylene and aromatic hydrocarbon compounded cobiling agent, in the light-removing tower adopting parallel-flow jet tray it adopts azeotropic rectification process to remove the water and acetic acid from acrylic acid aqueous solution. Said process method has higher dewatering rate and acrylic acid removing rate and lower acrylic acid carrying-out rate.

The invention discloses an ultrasonic vibrating aided welding test device. The device mainly comprises an ultrasonic vibration processing device, a supporting and adjusting mechanism, a welding platform, etc. According to the device, a welding part in normal welding is subjected to regular ultrasonic vibration processing through a vibrating gun, and a welding pool is vibrated, thus the welding seam metal crystallizing process is changed, and the uniformity of the structure performance of a welding joint can be improved, and as a result, the welding quality is improved; alternative pressure isapplied to the metal in crystallizing in the welding pool by the ultrasonic vibration, thus high impact wave is generated for cutting off the growing crystal grains with sufficient energy, and as a result, the quantity of crystal nucleuses can be increased, the crystal form can be changed, and the condensed welding seam metal crystal grains can be refined; and meanwhile, metal in the welding poolis stirred at high speed, thus gas and impurities can quickly float, and the components are uniform, and as a result, the condensing state of the metal in the welding pool can be improved, and the comprehensive mechanical properties of the welding seam metal can be improved.

The invention relates to a microcapsule dispersion stabilizer, which comprises a dispersing agent, a lubricating agent and a humectant, wherein the mass ratio of the dispersing agent to the lubricating agent to the humectant is 0.02-1.6: 1-60: 20. When the microcapsule dispersion stabilizer is stirred into microcapsule emulsion, the microcapsule dispersion stabilizer is dispersed between microcapsule particles so as to keep stability of the microcapsule emulsion and dispersion uniformity of the microcapsule particles, wherein through components of the dispersing agent, a gathering trend of the microcapsule particles is reduced and stability of the microcapsule emulsion is kept; components of the humectant have water-lock and moisturized functions, so that the speed of loss of core materials of the microcapsule particles can be reduced, and stability of performances of the microcapsule particles can be ensured in a long-term storage process; and components of the lubricating agent are beneficial to reduce damage of technique processes on microcapsules, such as spraying of the microcapsule emulsion and the like, and improve usability of the microcapsule emulsion. The invention further relates to the microcapsule emulsion and paper for daily use utilizing the microcapsule dispersion stabilizer.

The invention relates to an urban road system and a corresponding underground railway system, aiming at providing a scheme which can not only improve traffic efficiency of an urban road network and reduce energy consumption of urban traffic, but also improve urban structure and urban livable value. The technical scheme comprises the essential that in the whole or part of the urban area, a road network is structured according to the way of forming a net structure of hexagon added with triangle. Compared with a traditional rectangle city, the road of the hexagon added with the triangle can reduce at least 18.4 percent of road distance, and enable the road in each area inside the road network to be closed relatively, thereby enhancing traffic speed on an urban main road, and effectively improving traffic efficiency and urban traffic structure.

The present invention provides an acrylic acid purification light-removing tower whose lower stage adopts macroporous sieve-plate and upper stage adopts parallel flow jet tray. Said tower can effectively raise separation power and reduce temp. of tower bottom, reduce energy consumption and reduce the polymerization tendency of acrylic acid of tower bottom.

The present invention relates to antigen-binding compounds that inhibit CD39. The invention also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent diseases, e.g. cancer.

The invention discloses a nodular cast iron manhole cover casting method for preventing cold shut defects. Molten iron component selection is controlled, microelements exceeding general standards arenot allowed, reasonable nodulizing agents and nucleating agents are added, lanthanum can eliminate graphite deterioration and graphite floatation, the tendency of blooming graphite aggregation is decreased, the number of graphite nodules can be increased, nodulizing rate is increased, shrinkage porosity tendency is decreased, high-quality nodular cast iron liquid is provided, and the cold shut defects of a formed cast iron manhole cover are decreased. By strictly controlling casting temperature and casting modes, the probability of casting defects such as sand burning, shrinkage and deformation is reduced, and each casting mould is uniformly filled with molten iron. The cold shut defects are prevented by the aid of component control, casting temperature and mode control and the like in thecasting process, the nodular cast iron manhole cover is excellent in quality and mechanical property and worthy of popularization, and the process is conveniently controlled.

The invention relates to a concrete admixture for buildings. The concrete admixture is prepared by using alkali paper pulp liquid wastes as raw materials, adding rosins to react for 20-80min at 100-180 DEG C to obtain a product, and carrying out spray drying on the product to obtain a powder product. The product is applied to the concrete, reduces the water consumption and greatly improves the frost resistance of the concrete due to the air entrained property under the condition of ensuring the strength of the concrete. The invention can not only reduce the environmental pollution produced bypaper mills, but also provide inexpensive admixtures with excellent quality for the cement and concrete industries, thereby being a good strategy to protect environment and turn waste into wealth.

Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.

The invention provides a high-weatherability aqueous wall coating. The high-weatherability aqueous wall coating is prepared from, by weight, 30-38 parts of a pure acrylic emulsion, 18-24 parts of a PEVE emulsion, 8-10 parts of CPVC, 4-6 parts of a pigment, 10-16 parts of a filler, 15-21 parts of water, 0.2-0.4 parts of a wetting agent, 0.2-0.5 parts of a dispersant, 2-2.5 parts of a film forming assistant, 0.1-0.6 parts of a thickener, 0.1-0.3 parts of a mildew inhibitor, 0.5-0.6 parts of glycol and 9-14 parts of aluminum doped zinc oxide. The invention also provides a preparation method of the high-weatherability aqueous wall coating. The high-weatherability aqueous wall coating has the advantages of very good ozone ageing resistance, very good infrared reflection performance, and very good weatherability.

The invention discloses a quenching oil extraction visbreaking system. The quenching oil extraction visbreaking system comprises an extraction tower and a solvent recovery tower. The extraction tower is provided with a quenching oil inlet and a solvent inlet. The top of the extraction tower is connected to the middle of the solvent recovery tower. The top of the solvent recovery tower is connected to the solvent inlet of the extraction tower. Large-hole sieve trays are arranged at the lower section of the extraction tower. Any one plate-type tower or packed tower structure is arranged at the upper section of the extraction tower. The number of the large-hole sieve trays is 20-100% the total number of the tower plates. The sieve tower plates are used in the quenching oil extraction visbreaking system so that a heavy component can be separated well and visbreaking effects are improved. The extraction tower can effectively improve a tower separation capability, reduces polymerization tendency of the quenching oil at the tower bottom, reduces scaling and blocking of members in the tower, improves visbreaking effects and prolongs a production period.

The invention discloses a method for preparing a lightweight energy-saving building wall material by using high-content steel slag, and solves the problems of low utilization rate, low additional value and low consumption of the existing steel slag. The preparation method comprises the following steps: mixing 40-50 parts of steel slag, 10-20 parts of clinker, 0-20 parts of blast furnace slag, 40-50 parts of fly ash and 5 parts of desulfurized gypsum powder; performing mixing, adding 0.02-0.05% of a grinding-aid early strength agent, and performing fine grinding; adding 0-2% of reinforcing fibers into the mixture after fine grinding; mixing with foaming slurry, and adding a water reducing agent; after uniform stirring, pouring the mixture into a mold; curing the test piece for 1 day under the condition of constant humidity of 30 DEG C, performing demolding, performing curing for 3-6 days under the condition of constant humidity of 35-65 DEG C, and performing natural curing for 28 days to prepare the qualified light energy-saving wall material. The solid waste utilization rate can reach 90%, and the steel slag utilization rate can reach 42.5% or above.

The invention relates to the field of light component removal towers, specifically to an acrylic acid purification and light component removal tower. The acrylic acid purification and light componentremoval tower comprises an acrylic acid purification and light component removal tower body, a rectification section sieve plate, a filter screen mechanism, a cooling mechanism and a separation mechanism, wherein a feeding pipe communicating with the interior of the acrylic acid purification and light component removal tower body is fixedly connected to the middle part of the acrylic acid purification and light component removal tower body, and a gas outlet pipe is arranged at the top of the acrylic acid purification and light component removal tower body; the rectification section sieve plateis mounted in the acrylic acid purification and light component removal tower body, and is positioned above the feeding pipe; the filter screen mechanism is mounted in the acrylic acid purification and light component removal tower body, and is positioned above the feeding pipe; the cooling mechanism is connected with the acrylic acid purification and light component removal tower body; and the separation mechanism is connected to the interior of the acrylic acid purification and light component removal tower body. The acrylic acid purification and light component removal tower provided by the invention has the advantages of short acrylic acid production period and capability of reducing the blockage probability of the rectification section sieve plate.

A steel slag powder grinding aid for improving particle aggregation comprises, by weight, 45-48 parts of water, 4-6 parts of industrial salt, 2-3 parts of anhydrous sodium sulfate, 4-5 parts of sodiumnitrite, 2-4 parts of urea, 15-17 parts of compound alcohol amine, 17-20 parts of glycerol and 4-5 parts of sugar. The steel slag powder grinding aid can improve the grinding efficiency, improve theyield, reduce the power consumption of a mill, save energy and reduce the cost.

The invention discloses storable MPC (Milk Protein Concentrate) powder and a preparation method thereof, relating to MPC powder and a preparation method thereof, and solving the problems that the water solubility of existing MPC powder is reduced after the existing MPC powder is stored and an improving method researched for the existing MPC powder commonly has difficulty in industrialized production. A method 1 comprises the following steps: 1, processing a cow milk sample; 2, sterilizing; 3, removing lactose and partial minerals; 4, concentrating; 5, mixing; and 6, drying. A method 2 comprises the following steps: 1, processing a cow milk sample; 2, sterilizing; 3, removing lactose and partial minerals; 4, concentrating; 5, drying; and 6, mixing. According to the storable MPC powder, by adding different types of surfactants, the trend of polymerization of protein molecules is weakened, the emulsion stability of a system is improved, and the probability of particle enlargement and water solubility characteristic reduction caused by fat precipitation is lowered. The preparation method disclosed by the invention is simple in operation, low in cost, large in capacity, and capable of realizing industrialized production; conventional equipment is adopted in the preparation method.

The present invention relates to, among other things, methods and systems for recognizing and characterizing protein aggregation processes at the earliest possible time and use of such new methods and systems for (1) the identification and selection of protein formulations that minimize aggregation and extend long-term stability and (2) the identification of protein variants with the lowest tendency to aggregate.

The invention discloses a modified grinding-aiding early strength agent for steel slag as well as a preparation method and an application method of the modified grinding-aiding early strength agent, and relates to the field of steel slag grinding aiding. The modified grinding-aid early strength agent comprises (a) 60%-75% of ester compounds based on the total weight of the modified grinding-aid early strength agent; (b) 5%-15% of polyacrylic acid based on the total weight of the modified grinding-aid early strength agent; (c) 10%-35% of alcohol amine and acrylic acid monomers based on the total weight of the modified grinding-aid early strength agent, the preparation method comprises the following steps: adding water into alcohol amine and acrylic acid, uniformly mixing, heating while stirring, reacting at 60-80 DEG C for 3-4 hours, and cooling the solution to room temperature to obtain the modified grinding-aiding early strength agent which is applied to grinding of a gel material with high doping amount of steel slag, so the problems of low grinding efficiency of an existing grinding aid, low activity of the steel slag in the early stage, complex synthesis process, high cost and the like are solved. The preparation process is simple, the raw material cost is low, the finished product quality and performance are stable, the use effect is good, and the 7d strength increase is greater than or equal to 30%.

The present invention relates to a mouthwash including microspheres that incorporate an active ingredient, wherein the microspheres are obtained directly in situ in the aqueous phase of the mouthwash by cross-linking. These microspheres do not tend to aggregate and the mouthwash appears in the form of a homogenous and stable suspension even after prolonged storage.

The invention provides a high-W-content high-Mo-content nickel-base high-temperature alloy. The high-W-content high-Mo-content nickel-base high-temperature alloy comprises the following element components in percentage by mass of 0.013-0.018wt% of C, 20-21wt% of Cr, 7.9-8.1wt% of W, 7.9-8.1wt% of Mo, 0.6-0.75wt% of Al, 0.6-0.75wt% of Ti, 0.28-0.33wt% of Mn, 0.15-0.20wt% of Si, 0.002-0.013wt% of P,0.001-0.013wt% of S, 0.11-0.19wt% of Fe, 0.002-0.005wt% of B, 0.02-0.05wt% of Ce, 0.02-0.06wt% of Zr, and the balance Ni. According to the high-W-content high-Mo-content nickel-base high-temperaturealloy disclosed by the invention, the elemental composition compounding ratio is optimized, so that deposition tendency of carbides is reduced, the distribution of the carbides is more uniform, and gathering tendency is reduced.

The invention relates to a high-heat-insulation ultra-thin coating for a centrifugal casting cylinder liner. The coating is prepared from, by weight, 20-30 parts of cryolite powder, 18-22 parts of bentonite, 20-30 parts of high-alumina powder, 13-17 parts of coke powder, 4-6 parts of glaze powder, 1.5-2.5 parts of flour, 0.8-1.3 parts of soap powder, 6-8 parts of water glass and proper amount of water. The invention also discloses a production process of the high-heat-insulation ultra-thin coating. The high-heat-insulation ultra-thin coating has the advantages that in the centrifugal casting process of the cylinder liner, a high-heat-insulation adhesion layer is formed in an inner cavity of a die, a small amount of coating is added every time, when the thickness of the coating on the outersurface of a cylinder liner blank is only 0.2-0.3mm, normal production can be realized, the internal quality of the cylinder liner can be improved, the cost is reduced, the rejection rate is reduced,the cooling speed in the centrifugal casting process is remarkably reduced, A-type graphite is realized, the dendrite and aggregation tendency is reduced, the internal quality of the cylinder liner is improved, and the service life of the die is prolonged.

The present invention relates to novel antibody variable domain combinations with advantageous properties.

The invention discloses a preparation method of a high-temperature-resistant anti-foaming agent, and belongs to the technical field of anti-foaming agent preparation. Poplar wood is used as raw materials and is subjected to crushing, extraction, lignin removal and ultrasonic crushing to obtain lignin nanometer cellulose; then, methylsilicone oil soaking is performed; high-speed dispersion is performed with fumed silica to obtain the high-temperature-resistant anti-foaming agent; the wettability with an organic phase and the dispersibility are improved; at a high temperature, the oil phase diffusion speed of the nanometer cellulose is accelerated; the outer surface energy of surrounding bubbles is reduced, so that bubble breaking is caused; under the high-temperature conditions, the anti-foaming speed of the methylsilicone oil is accelerated to a certain extent; the methylsilicone oil achieving the anti-foaming effect has better chemical stability and cannot easily react with substancesin a foaming system; the affinity of the methylsilicone oil on cellulose is better than the affinity of water; the viscosity is high; the dissolution degree in the water is very low, so that the anti-foaming time of equivalent anti-foaming agent is longer; the pore structure of the cellulose is favorable for conversion of big foam into small bubbles, so that the anti-foaming effect of the anti-foaming agent is enhanced; the foam inhibition time is long; the application prospects are wide.

The invention discloses a preparation method for a textile defoamer, and belongs to the field of textile industry. Soybeans are used as a raw material to prepare epoxidized soybean oil, the epoxidizedsoybean oil in the defoamer and an alcoholic substance are mutually soluble, and undergo ring-opening in a strong alkaline textile slurry to reduce the outer surface tension of bubbles, and an external pressure crushes the bubbles to achieve defoaming, so that the defoamer stably exists in an alkaline environment; and microcrystalline cellulose, silica sol and other effective components are mixedand stirred, the obtained mixture is filtered to obtain a filter cake, the filter cake is a silicon-containing cellulose gel with pores, and is immersed in methylsilicone oil, and the obtained filtercake is dispersed in fumed silica oxidized soybean oil, amino silicone oil, anhydrous ethanol, isopropanol, white carbon black and other components at a high speed to obtain the textile defoamer.

The present invention relates to a process for the manufacture of an infusible beverage ingredient, the process comprising the steps of: (a) providing unsweetened fruit pieces; (b) treating the fruit pieces so as to reduce their total sugar content by at least 35%; and then subsequently (c) drying the fruit pieces to a moisture content of less than 30%, preferably to a moisture content of 0.1 to 10%, wherein step (b) of the process comprises a first centrifugation of the fruit pieces.

The present invention aims at providing a preparation method of novel mussel polypeptide oral liquid by using an enzymolysis technology of mainly using trypsin, pepsin and neutral protease to conduct enzyme digestion of purple mussels, and adding an emulsifier, a stabilizer and a seasoning material, and provides the new mussel polypeptide oral liquid product for the industry of functional food. The enzymolysis technology of different enzymes is used and the enzymolysis is conducted under the enzymolysis conditions at different enzyme activities, temperatures, pH and time. The preparation method uses different types of the protein stabilizer, emulsifier and flavoring agent, reduces the polymerization trend between protein molecules, improves the emulsion stability of the system, and reduces the problems of enlarged particles and decreased water soluble properties caused by fat precipitation.