43results about How to "Reduce tendency to aggregate" patented technology

The invention relates to processes for the preparation of highly concentrated, liquid formulations comprising at least one anti-EGFR antibody and/or one of its variants and/or fragments, in particular monoclonal antibodies against the EGF receptor, particularly preferably of Mab C225 (cetuximab) and Mab h425 (EMD 72000), by ultrafiltration. The invention furthermore relates to highly concentrated, liquid formulations of anti-EGFR antibodies, in particular of monoclonal antibodies against the EGF receptor, particularly preferably Mab C225 (cetuximab) and Mab h425 (EMD 72000) and/or variants and/or fragments thereof, characterised in that the highly concentrated, liquid formulations have a content of anti-EGFR antibodies of 10-250, preferably 50-180 mg/ml, particularly preferably of 100-150 mg/ml, and to the use thereof.

The invention discloses an ultrasonic vibrating aided welding test device. The device mainly comprises an ultrasonic vibration processing device, a supporting and adjusting mechanism, a welding platform, etc. According to the device, a welding part in normal welding is subjected to regular ultrasonic vibration processing through a vibrating gun, and a welding pool is vibrated, thus the welding seam metal crystallizing process is changed, and the uniformity of the structure performance of a welding joint can be improved, and as a result, the welding quality is improved; alternative pressure isapplied to the metal in crystallizing in the welding pool by the ultrasonic vibration, thus high impact wave is generated for cutting off the growing crystal grains with sufficient energy, and as a result, the quantity of crystal nucleuses can be increased, the crystal form can be changed, and the condensed welding seam metal crystal grains can be refined; and meanwhile, metal in the welding poolis stirred at high speed, thus gas and impurities can quickly float, and the components are uniform, and as a result, the condensing state of the metal in the welding pool can be improved, and the comprehensive mechanical properties of the welding seam metal can be improved.

The invention relates to an urban road system and a corresponding underground railway system, aiming at providing a scheme which can not only improve traffic efficiency of an urban road network and reduce energy consumption of urban traffic, but also improve urban structure and urban livable value. The technical scheme comprises the essential that in the whole or part of the urban area, a road network is structured according to the way of forming a net structure of hexagon added with triangle. Compared with a traditional rectangle city, the road of the hexagon added with the triangle can reduce at least 18.4 percent of road distance, and enable the road in each area inside the road network to be closed relatively, thereby enhancing traffic speed on an urban main road, and effectively improving traffic efficiency and urban traffic structure.

The present invention provides an acrylic acid purification light-removing tower whose lower stage adopts macroporous sieve-plate and upper stage adopts parallel flow jet tray. Said tower can effectively raise separation power and reduce temp. of tower bottom, reduce energy consumption and reduce the polymerization tendency of acrylic acid of tower bottom.

The invention relates to a concrete admixture for buildings. The concrete admixture is prepared by using alkali paper pulp liquid wastes as raw materials, adding rosins to react for 20-80min at 100-180 DEG C to obtain a product, and carrying out spray drying on the product to obtain a powder product. The product is applied to the concrete, reduces the water consumption and greatly improves the frost resistance of the concrete due to the air entrained property under the condition of ensuring the strength of the concrete. The invention can not only reduce the environmental pollution produced bypaper mills, but also provide inexpensive admixtures with excellent quality for the cement and concrete industries, thereby being a good strategy to protect environment and turn waste into wealth.

Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.

The invention discloses a quenching oil extraction visbreaking system. The quenching oil extraction visbreaking system comprises an extraction tower and a solvent recovery tower. The extraction tower is provided with a quenching oil inlet and a solvent inlet. The top of the extraction tower is connected to the middle of the solvent recovery tower. The top of the solvent recovery tower is connected to the solvent inlet of the extraction tower. Large-hole sieve trays are arranged at the lower section of the extraction tower. Any one plate-type tower or packed tower structure is arranged at the upper section of the extraction tower. The number of the large-hole sieve trays is 20-100% the total number of the tower plates. The sieve tower plates are used in the quenching oil extraction visbreaking system so that a heavy component can be separated well and visbreaking effects are improved. The extraction tower can effectively improve a tower separation capability, reduces polymerization tendency of the quenching oil at the tower bottom, reduces scaling and blocking of members in the tower, improves visbreaking effects and prolongs a production period.

The invention discloses a method for preparing a lightweight energy-saving building wall material by using high-content steel slag, and solves the problems of low utilization rate, low additional value and low consumption of the existing steel slag. The preparation method comprises the following steps: mixing 40-50 parts of steel slag, 10-20 parts of clinker, 0-20 parts of blast furnace slag, 40-50 parts of fly ash and 5 parts of desulfurized gypsum powder; performing mixing, adding 0.02-0.05% of a grinding-aid early strength agent, and performing fine grinding; adding 0-2% of reinforcing fibers into the mixture after fine grinding; mixing with foaming slurry, and adding a water reducing agent; after uniform stirring, pouring the mixture into a mold; curing the test piece for 1 day under the condition of constant humidity of 30 DEG C, performing demolding, performing curing for 3-6 days under the condition of constant humidity of 35-65 DEG C, and performing natural curing for 28 days to prepare the qualified light energy-saving wall material. The solid waste utilization rate can reach 90%, and the steel slag utilization rate can reach 42.5% or above.

The invention discloses storable MPC (Milk Protein Concentrate) powder and a preparation method thereof, relating to MPC powder and a preparation method thereof, and solving the problems that the water solubility of existing MPC powder is reduced after the existing MPC powder is stored and an improving method researched for the existing MPC powder commonly has difficulty in industrialized production. A method 1 comprises the following steps: 1, processing a cow milk sample; 2, sterilizing; 3, removing lactose and partial minerals; 4, concentrating; 5, mixing; and 6, drying. A method 2 comprises the following steps: 1, processing a cow milk sample; 2, sterilizing; 3, removing lactose and partial minerals; 4, concentrating; 5, drying; and 6, mixing. According to the storable MPC powder, by adding different types of surfactants, the trend of polymerization of protein molecules is weakened, the emulsion stability of a system is improved, and the probability of particle enlargement and water solubility characteristic reduction caused by fat precipitation is lowered. The preparation method disclosed by the invention is simple in operation, low in cost, large in capacity, and capable of realizing industrialized production; conventional equipment is adopted in the preparation method.

The present invention relates to, among other things, methods and systems for recognizing and characterizing protein aggregation processes at the earliest possible time and use of such new methods and systems for (1) the identification and selection of protein formulations that minimize aggregation and extend long-term stability and (2) the identification of protein variants with the lowest tendency to aggregate.

The invention discloses a modified grinding-aiding early strength agent for steel slag as well as a preparation method and an application method of the modified grinding-aiding early strength agent, and relates to the field of steel slag grinding aiding. The modified grinding-aid early strength agent comprises (a) 60%-75% of ester compounds based on the total weight of the modified grinding-aid early strength agent; (b) 5%-15% of polyacrylic acid based on the total weight of the modified grinding-aid early strength agent; (c) 10%-35% of alcohol amine and acrylic acid monomers based on the total weight of the modified grinding-aid early strength agent, the preparation method comprises the following steps: adding water into alcohol amine and acrylic acid, uniformly mixing, heating while stirring, reacting at 60-80 DEG C for 3-4 hours, and cooling the solution to room temperature to obtain the modified grinding-aiding early strength agent which is applied to grinding of a gel material with high doping amount of steel slag, so the problems of low grinding efficiency of an existing grinding aid, low activity of the steel slag in the early stage, complex synthesis process, high cost and the like are solved. The preparation process is simple, the raw material cost is low, the finished product quality and performance are stable, the use effect is good, and the 7d strength increase is greater than or equal to 30%.

The present invention relates to a mouthwash including microspheres that incorporate an active ingredient, wherein the microspheres are obtained directly in situ in the aqueous phase of the mouthwash by cross-linking. These microspheres do not tend to aggregate and the mouthwash appears in the form of a homogenous and stable suspension even after prolonged storage.

The present invention relates to novel antibody variable domain combinations with advantageous properties.

The invention discloses a preparation method for a textile defoamer, and belongs to the field of textile industry. Soybeans are used as a raw material to prepare epoxidized soybean oil, the epoxidizedsoybean oil in the defoamer and an alcoholic substance are mutually soluble, and undergo ring-opening in a strong alkaline textile slurry to reduce the outer surface tension of bubbles, and an external pressure crushes the bubbles to achieve defoaming, so that the defoamer stably exists in an alkaline environment; and microcrystalline cellulose, silica sol and other effective components are mixedand stirred, the obtained mixture is filtered to obtain a filter cake, the filter cake is a silicon-containing cellulose gel with pores, and is immersed in methylsilicone oil, and the obtained filtercake is dispersed in fumed silica oxidized soybean oil, amino silicone oil, anhydrous ethanol, isopropanol, white carbon black and other components at a high speed to obtain the textile defoamer.

The present invention relates to a process for the manufacture of an infusible beverage ingredient, the process comprising the steps of: (a) providing unsweetened fruit pieces; (b) treating the fruit pieces so as to reduce their total sugar content by at least 35%; and then subsequently (c) drying the fruit pieces to a moisture content of less than 30%, preferably to a moisture content of 0.1 to 10%, wherein step (b) of the process comprises a first centrifugation of the fruit pieces.

The present invention aims at providing a preparation method of novel mussel polypeptide oral liquid by using an enzymolysis technology of mainly using trypsin, pepsin and neutral protease to conduct enzyme digestion of purple mussels, and adding an emulsifier, a stabilizer and a seasoning material, and provides the new mussel polypeptide oral liquid product for the industry of functional food. The enzymolysis technology of different enzymes is used and the enzymolysis is conducted under the enzymolysis conditions at different enzyme activities, temperatures, pH and time. The preparation method uses different types of the protein stabilizer, emulsifier and flavoring agent, reduces the polymerization trend between protein molecules, improves the emulsion stability of the system, and reduces the problems of enlarged particles and decreased water soluble properties caused by fat precipitation.