Compositions containing cis-isomers of carotenoids and corresponding method

A carotene and composition technology, which is applied in the directions of medical preparations containing active ingredients, food preparation, drug combinations, etc., can solve problems such as inability to be used in the food field, and achieves difficult crystallization, low aggregation tendency, and good solubility. The effect of lipids

Inactive Publication Date: 2007-02-21
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with this composition is that it cannot be used in the food sector, moreover it is intended for coloring purposes
[0004] Although EP 1 289 383 provides primary compositions comprising at least one lipophilic bioactive compound and whey protein in an amount effective to increase the bioavailability of the lipophilic bioactive compound, there is still a need for bioavailability and bioefficacy Carotenoid-containing products higher than those currently on the market

Method used

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  • Compositions containing cis-isomers of carotenoids and corresponding method
  • Compositions containing cis-isomers of carotenoids and corresponding method
  • Compositions containing cis-isomers of carotenoids and corresponding method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation of Primary Compositions by Microwave Treatment

[0050] 25 grams of lycopene oleoresin manufactured by LycoRed Natural Products Industries, Ltd., Israel, was microwaved at about 105°C and 2.45 GHz for 150 seconds. The primary composition thus obtained was cooled under nitrogen to prevent degradation of the carotenoids. The cis:trans isomer ratio of lycopene in the resulting composition was about 65:35.

Embodiment 2

[0051] Example 2: Preparation of primary composition by heat treatment

[0052] 0.28 g of oleoresin (Indena 10% lycopene) in 30 ml of ethyl acetate was isomerized by heating at reflux under nitrogen for 1 hour and evaporating the solvent under reduced pressure. The cis:trans isomer ratio after heating was about 35%.

Embodiment 3

[0053] Example 3: Preparation of Primary Compositions by Reactions Between Free Radicals

[0054] 2 g oleoresin (Indena 10% lycopene) in 100 ml CH 2 Cl 2 with 116 μl iodine solution (2.8 mg iodine in 298 μl CH 2 Cl 2 )mix. The mixture was photoisomerized at room temperature for 1 h 50 min, and the solvent was removed under reduced pressure. The cis:trans isomer ratio after photoisomerization was about 77%.

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Abstract

The present invention relates to a primary composition that includes at least one carotenoid-containing extract, concentrate or oleoresin enriched in cis-isomers of the carotenoid compound, and process of forming the same. It also relates to an oral composition that contains the primary composition in a foodstuff, in a food supplement, in a cosmetic preparation or in a pharmaceutical preparation.

Description

[0001] The present invention relates to primary compositions of carotenoid-containing materials comprising at least one cis-isomer of a carotenoid-rich compound and methods of forming the same. It also relates to oral compositions comprising this primary composition in foods, food supplements, cosmetic preparations or pharmaceutical preparations. Background of the invention [0002] Commercially available compositions comprising the carotenoid, lycopene, are known. Lycopene is a natural product known to have multiple effects, especially as an antioxidant for the relief of chronic diseases. Lycopene is found in many natural products, especially tomatoes, melons, guavas and grapefruits. Lycopene-containing compositions generally available on the market are oleoresins. The problem with this oleoresin is that the bioavailability of the lycopene contained therein is insufficient. [0003] For example, European Patent 278 284 relates to powdered compositions comprising synthetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09B61/00A23L1/275A61K8/30A61Q19/08A61K31/015A23L1/30A23L33/15A61K8/31A61K8/34A61K8/35A61Q19/00
CPCA61K8/31A61K8/34A61K8/345A61K8/35A61K31/015A61K2800/92A61Q19/00A61Q19/005A61Q19/007A61Q19/08A23L33/105A61P9/00A61P17/16A61P17/18A61P35/00C09B61/00
Inventor K·博尔特利克M·里什勒P·朗伯莱F·绍西
Owner NESTEC SA
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