40results about How to "Minimizing aggregation" patented technology

The present invention provides stable lyophilized formulations of bispecific antibodies or fragments thereof.

Nanowire dispersion compositions (and uses thereof) are disclosed comprising a plurality of inorganic nanowires suspended in an aqueous or non-aqueous solution comprising at least one low molecular weight and / or low HLB (Hydrophile-Lipophile Balance) value dispersant. Methods of further improving the dispersability of a plurality of inorganic nanowires in an aqueous or non-aqueous solution comprise, for example, oxidizing the surface of the nanowires prior to dispersing the nanowires in the aqueous or non-aqueous solution.

The present invention provides stable lyophilized formulations of bispecific antibodies or fragments thereof.

A method (and system) for producing a halftoned image, includes calculating errors corresponding to a plurality of different viewing conditions of a halftone image, and minimizing a function of the errors, such that the halftoned image appears as a different image under different viewing conditions. Alternatively, in another embodiment, the halftoned image appears as the same image under different viewing conditions.

The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable formulations show optimal percent adsorption for each conjugate wherein, aggregation can be prevented by employing i) Individual or separate adsorption for conjugates that otherwise show lower percent adsorption by combined adsorption ii) Histidine-Succinic acid buffer system along with shift in pH from neutral pH to acidic pH iii) a polysaccharide to protein ratio between 0.5 to about 1.4 iv) a six-bladed Rushton type turbine impeller in formulation vessels.

A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surface modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a collidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as fuctionalization with a variety of different chemical groups, expanding their utility and application.

A service is provided to users of communication devices present in a geographic service area. Each device is associated with a specific user. The service comprises conditionally alerting a user, via his / her communication device, to a presence of another device of another user. The alerting occurs if the other user is registered as a buddy of the user and if a geographical distance between the user's device and the buddy's device is smaller than a pre-determined threshold. A succession of polling cycles is run. In each polling cycle, the mobile devices are sequentially polled based on location and according to a ranking determined in a preceding polling cycle that minimizes a value of a sum of terms. Each respective term indicates a respective difference between rankings of the mobile device of the respective user and of the mobile device of the buddy of the respective user.

An electroluminescent (EL) is provided comprising an anode, an organic electroluminescent element, and a cathode wherein the electroluminescent element contains, for example, a fluorescent 1,1′-binaphthyl derivative component of Formula (I) wherein R1, R2, R3 and R4 are individual substituents or a group of substituents, each of which may be selected from the group consisting of hydrogen, or alkyl of from 1 to about 25 carbon atoms; an alicyclic alkyl of from 3 to 15 carbon atoms; an aryl or substituted aryl with about 6 to about 30 carbon atoms; carbon atoms from 4 to 24 necessary to complete a fused aromatic ring of naphthalene, anthracene, perylene and the like; an alicyclic alkyl group with from about 3 to about 15 carbon atoms; a silicon atom which can be substituted with a trimethyl, diphenylmethyl, triphenyl group and the like; heteroaryl or substituted heteroaryl of from 5 to 24 carbon atoms, carbon atoms necessary to complete a fused heteroaromatic ring of furyl, thienyl, pyridyl, quinolinyl and other heterocyclic systems; an alkoxy, amino, alkyl amino or aryl amino of from 1 to about 25 carbon atoms; a halogen, a cyano group, and the like.

A method of increasing productivity, in particularly cell-specific productivity, of recombinant factor VIII (rFVIII) produced in a eukaryotic cell suspension during culturing of the eucaryotic cell suspension in a culturing medium containing not more than 500 μM CaCl2, at least a non-ionic detergent and other nutrient components needed for the cells to grow and produce rFVIII, the cell suspension is cultured under conditions inducing a shear stress mechanically to the eucaryotic cell suspension by adding a power density of at least 3 W / m3.

Provided is a fluorescent probe composition including an indolizino[3,2-c]quinoline-based compound, and a nucleic acid / protein / cell imaging method using the same. Since the compound of the present invention demonstrates excellent environmental sensitivity, fluorescence intensity, photostability, nucleic acid / protein binding, intracellular permeability, etc., the compound may be effectively used for various studies of protein / cell functions and imaging technologies, such as nucleic acid / protein kinetics, drug-protein interactions, and intracellular protein imaging.