Combined drug of pantoprazole and domperidone

A technology of domperidone and pantoprazole, which is applied in the field of combination medicine of pantoprazole and domperidone, to achieve strong acid suppression ability and the effect of inhibiting the secretion of gastric acid

Inactive Publication Date: 2011-02-02
CHENGDU ZIHAO PHARMA
View PDF13 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no relevant report on...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combined drug of pantoprazole and domperidone
  • Combined drug of pantoprazole and domperidone
  • Combined drug of pantoprazole and domperidone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prepare the freeze-dried powder injection of pantoprazole sodium and domperidone according to the following formula:

[0028] Pantoprazole sodium (equivalent to pantoprazole 40g) 45.1g

[0029] Domperidone 10g

[0030] Mannitol 100g

[0031] Sodium chloride 22.5g

[0032] Polyethylene Glycol-6000 10g

[0033] Sodium edetate 1.0g

[0034] Appropriate amount of sodium hydroxide

[0035] The preparation method is as follows: Weigh the prescribed amount of pantoprazole sodium, domperidone, mannitol, polyethylene glycol-6000 and sodium edetate, dissolve them in an appropriate amount of water for injection, control the temperature at about 70°C and stir Make it dissolve; add 0.1mol / L sodium hydroxide solution, adjust the pH value to about 10, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, decarbonize by coarse filtration, add water for injection to the full amount, mix Evenly, measure the content and pH value, after passing the test, filter it with a 0....

Embodiment 2

[0037] Prepare the freeze-dried powder injection of pantoprazole sodium and domperidone according to the following formula:

[0038] Pantoprazole sodium (equivalent to pantoprazole 40g) 45.1g

[0039] Domperidone 20g

[0040] Mannitol 150g

[0041] Sodium chloride 30g

[0042] Polyethylene Glycol-6000 20g

[0043] EDTA 1.0g

[0044] Appropriate amount of sodium hydroxide

[0045] Its preparation method is: take prescription amount of pantoprazole sodium, domperidone, glucose, polyethylene glycol-6000 and ethylenediaminetetraacetic acid, dissolve it in an appropriate amount of water for injection, control the temperature at about 70°C and stir to make it Dissolve; add 0.1mol / L sodium hydroxide solution, adjust the pH value to about 10, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, decarbonize by coarse filtration, add water for injection to the full amount, mix well, Determine the content and pH value. After passing the test, filter it with a 0.22 μm mic...

Embodiment 3

[0047] Prepare the freeze-dried powder injection of pantoprazole sodium and domperidone according to the following formula:

[0048] Pantoprazole sodium (equivalent to pantoprazole 20g) 22.6g

[0049] Domperidone 10g

[0050] Glucose 60g

[0051] Sodium chloride 15g

[0052] Polyethylene Glycol-6000 15g

[0053] Sodium edetate 1.0g

[0054] Appropriate amount of sodium hydroxide

[0055] Its preparation method is: take prescription amount of pantoprazole sodium, domperidone, glucose, polyethylene glycol-6000 and ethylenediaminetetraacetic acid, dissolve it in an appropriate amount of water for injection, control the temperature at about 70°C and stir to make it Dissolve; add 0.1mol / L sodium hydroxide solution, adjust the pH value to about 10, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, decarbonize by coarse filtration, add water for injection to the full amount, mix well, Determine the content and pH value. After passing the test, filter it with a 0.2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a combined drug of pantoprazole and domperidone and in particular provides application of pantoprazole and domperidone to preparing combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia. The invention also provides the combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia, including different specifications of unit preparations, pantoprazole and domperidone for simultaneous, respective or successive administration and preparations prepared by pharmaceutically acceptable vectors. The weight ratio of pantoprazole and domperidone is 1:1-5:1, and the pantoprazole and domperidone contain excipients, stabilizing agents, etc. Through combined injection administration, the invention improves the bioavailability of pantoprazole and domperidone and ensures the treatment effects to be obviously better.

Description

technical field [0001] The present invention relates to the combined medicine of pantoprazole and domperidone, specifically, the application in the preparation of combined injection medicine for treating gastric ulcer, duodenal ulcer, gastroesophageal reflux disease or functional dyspepsia. Background technique [0002] Pantoprazole is a proton pump inhibitor (PPI), which is relatively stable under neutral and weakly acidic conditions, and is rapidly activated under strongly acidic conditions. has better selectivity. It can specifically inhibit the H+, K+-ATPase on the secretory microtubules formed by the apical membrane of the parietal cell and the tubular vesicle in the cytoplasm, causing irreversible inhibition of the enzyme, thereby effectively inhibiting the secretion of gastric acid. Since H+, K+-ATPase is the last process of parietal cell acid secretion, pantoprazole has a strong ability to suppress acid. It can not only non-competitively inhibit gastric acid secret...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4439A61P1/04A61P1/14A61K9/19A61K9/08A61K31/454A61K9/14
Inventor 李玲冯凌刘忠荣何宇新刘小军
Owner CHENGDU ZIHAO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap