Traditional Chinese medicine for stomach dynamic

A technology of gastric motility and traditional Chinese medicine, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of obvious side effects of morphine, and achieve the effect of alleviating gastric motility disorder, low price and small dosage

Active Publication Date: 2006-06-21
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the side effects of morphine are also obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 - preparation of Muxiangweitai dripping pills

[0055] Prescription: Muxiang Weitai 100

[0056] PEG6000 300~500

[0057] Operation: Melt the prescribed amount of matrix on a water bath at 85°C, add Muxiangweitai under stirring, mix well, keep warm at 85°C for 10-20 minutes, and drop to 5- In the condensing agent at 15°C, take out the dripping pills, wipe off the condensing agent, and granulate. Each dropping pill weighs 30-50 mg, contains 7.5 mg of Muxiang Weitai, which is equivalent to 0.25 g of Muxiang crude drug, and has a yield of 85-98%.

Embodiment 2

[0058] Example 2 - Preparation of Muxiangweitai Dispersible Tablets

[0059] Prescription: Muxiangweitai-β-cyclodextrin inclusion complex 30

[0060] Low-substituted hydroxypropyl cellulose 10~20

[0061] Starch 35~45

[0062] Crospovidone XL-10 5~15

[0063] Operation: Muxiangweitai-β-cyclodextrin inclusion compound, low-substituted hydroxypropyl cellulose, starch, crospovidone XL-10, pulverized, mixed, passed through a 100-mesh sieve, and used 1-2% hydroxyl Propyl methyl cellulose is granulated, passed through a 40-mesh sieve, dried at 30-55°C for 3-5 hours, passed through a 20-mesh sieve for granulation, adding 1-4% crospovidone XL and 0.5-1.0% stearin Magnesium acid, mixed evenly, tableted, each tablet weighs 200-400mg, contains 15mg of Muxiangweitai, which is equivalent to 0.5g of Muxiang crude drug, and the yield is 80-98%.

Embodiment 3

[0064] Example 3——Preparation of Muxiangweitai liquid-filled capsules

[0065] Prescription: Muxiang Weitai 100

[0066] Polyethylene glycol 4000 200~350

[0067] Polyethylene glycol 400 200~350

[0068] Operation: Mix the prescribed amount of polyethylene glycol 4000 and the prescribed amount of polyethylene glycol 400 evenly, melt at 55-75°C, slowly cool down to 40-50°C, add the prescribed amount of Muxiang Weitai, mix well, Keep it warm for 10-50 minutes, exhaust the air bubbles, and fill it into capsules with a liquid-filled capsule filling machine. Each capsule weighs 100-400 mg, contains 30 mg of Muxiang Weitai, which is equivalent to 1.0 g of Muxiang crude drug, and the yield is 80-98%.

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PUM

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Abstract

The Chinese medicine gastric dynamia medicine is Chinese medicine preparation with aucklandia Weitai extracted from aucklandia as the main material, and aucklandia Weitai contains total aucklandia lactone in 50-90 wt%. Animal test shows that the Chinese medicine gastric dynamia medicine has the effect of promoting gastric dynamia and remitting gastric adynamia similar to that of Domperidone, the analgetic effect superior to Domperidone and has no side effect of Domperidone. In addition, it has small dosage and low cost.

Description

[0001] Field: [0002] The invention belongs to a traditional Chinese medicine, in particular to a traditional Chinese gastric motility drug capable of increasing human gastric motility. Background technique: [0003] The representative drug of gastric motility drug is the chemical drug morphine tablet. It holds the number one market share in the drug market for patients with gastric dysmotility disorders. But the side effects of morphine are also obvious. Because patients with gastric motility disorder may have recurrent attacks, they often take repeated medications, and more attention should be paid to the side effects, such as dry mouth, rash, headache, dizziness, lassitude, lethargy, diarrhea, nervousness, lactation, and feminization of gynecomastia. Invention content: [0004] The object of the present invention is to provide a traditional Chinese medicine gastric motility medicine, which can promote gastric motility, alleviate gastric motility disorder, has analgesic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/289A61K9/20A61K9/48A61K125/00A61P1/14
Inventor 孔伶俐魏吉城
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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