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Domperidone tablet and preparation method thereof

A technology for perperidone tablets and domperidone is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, which can solve the problems of slow disintegration of tablets and slow drug speed, and achieve the dissolution High, reduced equipment and operating costs, excellent appearance

Inactive Publication Date: 2014-09-10
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets prepared by wet granulation were slower to disintegrate and release drug into the dissolution medium at a slower rate

Method used

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  • Domperidone tablet and preparation method thereof
  • Domperidone tablet and preparation method thereof
  • Domperidone tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]

[0047] Preparation method: the domperidone raw material is pulverized with an airflow mill, and 1000 tablets of the domperidone raw material of the prescription amount are weighed for subsequent use; the method of equal increments is adopted, and the domperidone raw material and the cross-linked sodium carboxymethyl cellulose and the prescription amount of the croscarmellose sodium and Carboxymethyl starch sodium is fully mixed, and then fully mixed with the prescribed amount of microcrystalline cellulose, direct-pressed lactose, and magnesium stearate in turn; the mixed powder is tested for bulk density and angle of repose, and the weight of the tablet should be converted according to the content. Carry out tablet compression, adjust the hardness of the tablet to 2-3kg, and the difference in filling capacity is ±5.0%.

Embodiment 2

[0049]

[0050] Preparation method: the domperidone raw material is pulverized with an airflow mill, and 1000 prescription quantities of domperidone raw materials are taken for subsequent use; the equal amount of incremental method is adopted, and the domperidone raw material and the prescription quantity of croscarmellose sodium are fully Mix, and then fully mix with the prescribed amount of pregelatinized starch, sodium hydroxymethyl starch, microcrystalline cellulose, direct-compressed lactose, and magnesium stearate; after the content of the mixed material is tested, it should be converted into tablets according to the content Weight, perform tablet compression, adjust the hardness of the tablet to 2-3kg, and the difference in filling capacity is ±5.0%.

Embodiment 3

[0052]

[0053] Preparation method: pulverize the domperidone raw material with a jet mill, weigh 1000 pieces of the prescribed amount of domperidone raw material, and set aside; adopt the method of increasing the same amount, first fully mix the domperidone raw material with the prescribed amount of carboxymethyl starch sodium, and then Fully mix with the prescribed amount of pregelatinized starch, microcrystalline cellulose, direct-pressed lactose, and magnesium stearate in turn; after the mixed powder is tested for the angle of repose and bulk density content, the weight of the tablet should be converted according to the content, and the compression is carried out. Tablets, adjust the hardness of the tablets to 2-3kg, and the difference in filling capacity is ±5.0%.

[0054] The dissolution curves of the above-mentioned examples were measured respectively, and the results are shown in Table 1.

[0055] Table 1 each embodiment sample stripping curve value

[0056]

[...

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Abstract

The invention provides a domperidone tablet and a preparation method thereof. The domperidone tablet is prepared by carrying out direct powder compression on powder, a production is simple, a production cycle is shortened, equipment cost and operational cost are reduced, the prepared domperidone tablet is excellent in appearance, a technological process is smooth, operability is good, dissolution rate of the domperidone tablet product is high, content uniformity is qualified, and good bioavailability in a human body can be realized, so that good curative effect is realized.

Description

field of invention [0001] The invention belongs to the field of medicines, and in particular relates to tablets containing domperidone and a preparation method thereof. Background of the invention [0002] Due to the accelerated pace of life in modern society, changes in diet and many other factors, the number of people suffering from gastric hypomotility is increasing day by day. Hypogastric motility often leads to functional dyspepsia, gastroesophageal reflux and other diseases, which greatly affects people's quality of life. According to statistics, the incidence rate of gastric disease in my country is about 7% to 10%, and the number of patients is about 300 million people, ranking first in the world. According to reports, gastrointestinal drugs have always occupied a large market share, and the annual sales of gastrointestinal drugs in the world are about 13 billion US dollars, making it the third largest drug market. According to domestic epidemiological surveys, gast...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/454A61K47/38A61K47/36A61K47/26A61K47/12A61P1/04
Inventor 陈颖田艳秀王侠李畅
Owner QINGDAO MUNICIPAL HOSPITAL
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