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Domperidone orally disintegrating tablets as well as preparation method and quality control method thereof

A technology of orally disintegrating dipperidone and domperidone, which is applied in the field of medicine and can solve problems such as affecting curative effect, suffering of patients, inconvenient administration, etc.

Inactive Publication Date: 2009-04-15
SHAANXI BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Domperidone is a peripheral dopamine receptor agonist, which has been recognized by the majority of patients and medical workers. It is mainly used clinically for delayed gastric emptying, gastroesophageal reflux, dyspepsia caused by esophagitis, epigastric fullness, and abdominal distension. , epigastric pain, belching, flatulence, nausea, vomiting, stomach burning with or without regurgitation of gastric contents in the mouth; but for the treatment of functional, organic, infectious, dietary, radiation therapy Or nausea and vomiting caused by chemotherapy, when treating clinical cases such as nausea and vomiting caused by Parkinson's disease with dopamine receptor agonists (such as levodopa, bromocriptine, etc.), there are quite a few cases of clinical response in After taking it with warm water, it immediately causes vomiting reflex, causing the medicine just taken to vomit out again, resulting in inaccurate dosage and affecting the curative effect. Clinicians have to use antiemetic injections for treatment, which is inconvenient to administer and makes the patient suffer. pain

Method used

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  • Domperidone orally disintegrating tablets as well as preparation method and quality control method thereof
  • Domperidone orally disintegrating tablets as well as preparation method and quality control method thereof
  • Domperidone orally disintegrating tablets as well as preparation method and quality control method thereof

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Embodiment Construction

[0059] Example 1 of the present invention: 76g of mannitol, 10g of low-substituted hydroxypropyl cellulose, and 0.25g of stevioside are sieved and mixed, and set aside; Domperidone 10g is mixed with the above-mentioned mixture through an 80-mesh sieve by an equal increase method, and prepared with water Soft material, granulated with a 30-mesh sieve, ventilated and dried at 65°C for 0.5 hours, granulated with a 20-mesh sieve; 3g of talc powder, 0.7g of magnesium stearate and the granules prepared above are fully mixed, and pressed into tablets.

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Abstract

The invention discloses a domperidone oral disintegrating tablet, and a method for preparing the same and a method for quality control. The domperidone oral disintegrating tablet is prepared from domperidone and auxiliary materials, and the quality thereof is controllable and stable. The domperidone oral disintegrating tablet is a peripheral dopamine receptor agonist which is safe and effective. Compared with the prior art, the domperidone oral disintegrating tablet has the advantages of rapid disintegration, convenient taking, no vomiting, rapid effect, and low side effect.

Description

technical field [0001] The invention relates to domperidone orally disintegrating tablets, a preparation method and a quality control method thereof, and belongs to the technical field of medicine. Background technique [0002] Domperidone is a peripheral dopamine receptor agonist, which has been recognized by the majority of patients and medical workers. It is mainly used clinically for delayed gastric emptying, gastroesophageal reflux, dyspepsia caused by esophagitis, epigastric fullness, and abdominal distension. , epigastric pain, belching, flatulence, nausea, vomiting, stomach burning with or without regurgitation of gastric contents in the mouth; but for the treatment of functional, organic, infectious, dietary, radiation therapy Or nausea and vomiting caused by chemotherapy, when treating clinical cases such as nausea and vomiting caused by Parkinson's disease with dopamine receptor agonists (such as levodopa, bromocriptine, etc.), there are quite a few cases of clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/454A61P1/08A61P1/04
Inventor 赵涛
Owner SHAANXI BUCHANG PHARMA
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