Traditional Chinese medicinal composition for treating intestinal function disorder and its preparation method

A technology for intestinal dysfunction and composition, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of inability to meet clinical requirements, high treatment costs, and limited treatment methods.

Inactive Publication Date: 2005-02-16
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods are limited, and most of them start from relaxing intestinal smooth muscle, stimulating and antagonizing neurotransmitters, and anti-anxiety, with limited effects
And the drugs are often aimed at treating single symptoms such as diarrhea or constipation, mainly focusing on the regulation of intestinal microecology, antidepressant, prokinetic drug treatment, calcium channel ant

Method used

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  • Traditional Chinese medicinal composition for treating intestinal function disorder and its preparation method
  • Traditional Chinese medicinal composition for treating intestinal function disorder and its preparation method
  • Traditional Chinese medicinal composition for treating intestinal function disorder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0275] Example 1, the prescription is: Bupleurum 6 grams, Radix Paeoniae Alba 6 grams, Radix Pseudostellariae 3 grams, Radix Glycyrrhizae 6 grams.

[0276] The above composition is extracted with water, ethanol, or other organic solvents;

[0277] Purification, separation and drying: the extract of water or ethanol is obtained by vacuum concentration, ethanol precipitation, resin adsorption, resin exchange, high-speed centrifugation, cyclodextrin inclusion and other methods;

[0278] Granules, capsules, tablets, preparations for transdermal or transmucosal administration, and suppositories for rectal administration prepared by adding appropriate pharmaceutical adjuvants to the above drugs.

Embodiment 2

[0279] Example 2 is basically the same as Example 1, but the prescription is: Bupleurum 18 grams, Radix Paeoniae Alba 30 grams, Radix Pseudostellariae 18 grams, Radix Glycyrrhizae 15 grams. At the same time, the preparation method is changed to:

[0280] The above composition is extracted with water, ethanol, or other organic solvents;

[0281] Purification, separation and drying: the extract of water or ethanol is obtained by vacuum concentration, ethanol precipitation, resin adsorption, resin exchange, high-speed centrifugation, cyclodextrin inclusion and other methods;

[0282] The above extracts are directly or purified and separated by adding appropriate pharmaceutical excipients to prepare granules, capsules, tablets, oral liquids, injections, transdermal or transmucosal administration preparations, and suppositories for rectal administration.

Embodiment 3

[0283] Example 3 is basically the same as Example 1 or 2, but the prescription is: Bupleurum 12 grams, Radix Paeoniae Alba 12 grams, Radix Pseudostellariae 6 grams, Radix Glycyrrhizae 6 grams.

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Abstract

The invention is a Chinese traditional medicine compound for treating intestines functions disorder. The compound includes following ingredients: bupleurum root 6-18g, white peony root 6-30g, pseudostellaria root 3-18g, liquorice 6-15g. The method can be used in clinic directly without adding ingredients; it also can use the extract of above mentioned medicines as medicine; the extract is: a. extract the volatile oil for backup from above mentioned compound; b. carries on extraction with water, alcohol, or other organic solution to above mentioned volatile oil compound; c. purifies and separates: water extracting liquid, vacuum condensing, and alcohol depositing, resin absorbing and exchanging, high speed eccentric process, and cyclodextrin packaging method; d. the extracts in above steps are combined, and become medicine compound. There also can increase lagehead atractylodes, chuaniong rhizome, Tuckahoe, kudzu vine root, uncaria and other medicines; or some compounds such as shimida, and dopan ketone. The invention also provides a manufacturing method for above mentioned medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound composition for treating diseases related to intestinal dysfunction and its modern preparation, as well as a process for preparing the pharmaceutical composition. Background technique [0002] Irritable bowel syndrome (IBS) is a common non-organic intestinal dysfunction disease of the digestive tract, with clinical characteristics of chronic recurrent attacks. The clinical symptoms are abdominal discomfort (abdominal pain, bloating) and abnormal intestinal motility, such as changes in bowel habits (diarrhea or constipation), abnormal stool properties (loose stools, mucus stools, or hard stools), and increased frequency of bowel movements. Existence or intermittent attacks, pathological examination mostly no specific intestinal inflammatory lesions, clinically divided into diarrhea type, constipation type, alternating type. Modern medicine believes that the pathogenesis of IBS is related ...

Claims

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Application Information

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IPC IPC(8): A61P1/14
Inventor 杨星昊
Owner NANJING NORMAL UNIVERSITY
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