115 results about "D-Sorbitol" patented technology

The present invention provides a composition alleviated in a bitter taste or the like of a medicament. The present invention relates to a composition comprising a basic medicament having an unpleasant taste and polyvinylpyrrolidone and/or copolyvidone; or a method for alleviating an unpleasant taste of a basic medicament having the unpleasant taste by adding polyvinylpyrrolidone and/or copolyvidone. The present invention further provides a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (3) propylene glycol and/or D-sorbitol; a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (4) an antioxidant; and a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (5) a colorant or flavor containing a sulfuric acid or sulfurous acid group.

The invention relates to an oxiracetam freeze-drying preparation for injection and a preparation method thereof, belonging to the technical field of medicines. The freeze-drying preparation is a crystal form compound formed by oxiracetam, D-sorbitol and mannitol in a weight ratio of 1: (0.2-0.25): (0.05-0.1). The oxiracetam freeze-drying preparation has the beneficial effects that the production cycle is shortened by about 20 hours, the rate of finished products is increased by above 99%, the phenomena such as the upward shifting and the eruption of the product are avoided, medicine molecules are constrained in crystal lattices, the water content is extremely low and can be controlled below 0.1%, the preparation is difficult to degrade and has relatively good stability, the period of validity is up to 36 months, the impurity content is greatly reduced, the single maximum impurity is less than 0.1%, and the total impurities are less than 0.5%; no organic solvents are involved in the production process, the energy consumption and the cost are substantially reduced, and the technology has environmentally-friendly effect and is suitable for large-scale industrialization production. Compared with the prior art, the oxiracetam freeze-drying preparation provided by the invention has obviously improved curative effect and is suitable for clinical application.

The invention discloses a preparation method of high-purity 1,4-sorbitan, which is characterized by taking D-sorbitol as a raw material through dewatering twice and three times of crystallization. The method comprises the following steps of: (1) adding polyatomic alcohol in a reaction vessel; (2) stirring, heating and decompressing for removing free water; (3) cooling down and adding an acidic catalyst; (4) stirring, heating and decompressing for dehydrating a molecule of water; (5) neutralizing and filtering for separating the catalyst; (6) decolorizing; (7) carrying out crystallization for three times in lower alcohol to prepare the 1,4-sorbitan with more than 99% of content. The preparation method fills up the blank of 1,4-sorbitan industrial production technique; the prepared 1,4-sorbitan can be used for synthesizing high-purity surfactants, such as Span, Tween, sorbitan fatty acid ester or polysorbate and the like; and the polysorbate-80 synthesized by the prepared 1,4-sorbitan can satisfy the standard of injection-level pharmaceutic adjuvant.

The invention discloses a dried fruit jam of a layer cake for industrial production and a preparation method and applications thereof. The jam comprises the following components: 20-35% of granulated sugar, 30-40% of high fructose corn syrup, 10-20% of d-sorbitol solution, 5-10% of modified starch, 2-8% of edible glycerol, 0.5-0.7% of composite colloid, 0.6-0.8% of composite chelate salt, 0.1-0.3% of citric acid and 2-5% of dried fruit. According to the dried fruit jam, the modified starch, the composite colloid, the composite chelate salt are evenly mixed, water is added and then the mixture is stirred for dissolving until no obvious particle exists to obtain slurry; the high fructose corn syrup, the d-sorbitol solution and the granulated sugar are stirred and mixed, the slurry is added and the mixture is stirred while being heated; the mixture is heated and pasted to volatilize water until the content of solid content is 80-82%; the edible glycerol is added and the mixture is evenly mixed and cooled to 85-95 DEG C; and the dried fruit and the citric acid solution are added and the mixture is evenly stirred to obtain the jam. According to the dried fruit jam, the water activity of the jam is below 0.45, the mouthfeel is smooth and fine. The jam does not stick to teeth and the melting degree in mouth is high. The gel-state jam has a low heating temperature and can conveniently industrially prepare layer cakes.

The invention relates to an inorganic binder for nonferrous metal 3D sand mould printing and a preparation method thereof. The inorganic binder for nonferrous metal 3D sand mould printing comprises, by weight, 22%-34% of sodium silicate, 2%-11% of sodium hydrogen phosphate, 1.5%-5.5% of D-sorbitol, 0.2%-0.8% of water soluble silicone oil, 0,7%-2.3% of tetraethyl silicate, 0.3%-0.7% of aluminum sulfate, 0.3%-0.7% of naphthalene sulfonic acid, 0.4%-2.6% of phenolic resin, 0.7%-2.3% of sodium hydroxide and 46%-66% of deionized water. The inorganic binder for nonferrous metal 3D sand mould printing has the advantages that when the temperature of the prepared inorganic binder is 25 DEG C, the viscosity is smaller than 15 mpa.s, so that the using demand of sand mould ink jetting and printing is met; the bonding strength is high; the scattering performance of the binder is excellent, and casting sand removal is easy when the inorganic binder is applied to the casting field; and the moisture absorption resistance performance of the binder is excellent, the applicable time is short, and the binder can be quickly hardened.

The invention discloses a heat-resisting protective agent for freeze-dried vaccine and a preparing method and application thereof. The heat-resisting protective agent is prepared from, by mass, 0.3-0.6% of L-sodium glutamate, 8-14% of saccharose, 2-5% of D-sorbitol, 1-3% of bovine serum albumin, 0.1-0.3% of polyvinylpyrrolidone, 0.2-1% of thiourea, 3-5% of NZ-Amine AS, 0.8-1.5% of hydrolyzed gelatin and the balance PBS with PH of 7.2. The heat-resisting protective agent for freeze-dried vaccine can be applied to freeze-drying of porcine pseudorabies live vaccine and porcine reproductive and respiratory syndrome live vaccine after being subjected to asepsis treatment. By adopting the same heat-resisting protective agent and freeze-drying technology for the two viruses, freeze-drying loss is lower than 0.2 titer, virus content titer is lower than one titer after the viruses are stored at 37 DEG C for seven days, and the viruses can be stored for 24 months at 2-8 DEG C; convenience is brought for production of freeze-dried vaccine, and product quality and competitiveness are improved.

The invention concerns improved sugar-free products, their production and use, in particular, coated products, their production and use. The products are characterized by their content in enriched mixtures of 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM) and 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS).

The present invention relates to a method for recrystallizing diacetal, such as 1,3:2,4-bis-O-(benzylidene)-D-sorbitol or a nuclearly substituted derivative thereof, in a polyolefin resin without giving a yellowish tint to the polyolefin resin; a polyolefin resin molded article containing a recrystallized diacetal which is obtainable by said recrystallization method; a method for producing polyolefin resin pellets containing the recrystallized diacetal by utilizing said recrystallization method, and polyolefin resin pellets obtainable by the above method; and a method for producing a polyolefin resin molded article by heating and melting said pellets at a temperature not lower than its sol-gel transition temperature during the heating cycle and rapidly cooling the melt; and a polyolefin resin molded article obtainable by said method.

The invention provides a fresh flower antistaling agent and a preparation method thereof. The antistaling agent comprises food-grade wax, gibberellin, propolis, chitosan, catechin, sodium polyacrylate, D-sorbitol, nicotinamide, phytic acid, glycolamide, polyvinyl alcohol, triethanolamine, stearic acid, glyceryl monostearate, sodium dodecyl sulfate, fatty alcohol polyoxyethylene ether, and deionized water. The preparation method comprises: melting the food-grade wax, and adding triethanolamine, stearic acid, glyceryl monostearate, sodium dodecyl sulfate, and fatty alcohol polyoxyethylene ether while performing stirring to obtain a mixed solution I; adding gibberellins, propolis, chitosan, catechin, sodium polyacrylate, D-sorbitol, nicotinamide, phytic acid, and glycolamide into deionized water while performing stirring a mixed solution II; and finally adding the mixed solution I into the mixed solution II while performing stirring to obtain the fresh flower antistaling agent. According to the invention, the fresh flower antistaling agent is free of hormones, and has advantages of a good sterilization and bacterium prevention effect, wide flower and plant application, and a food fresh-keeping effect.

The invention relates to artificial feed for silkworms. The artificial feed is made from, by weight, 30% to 40% of mulberry leaf powder, 30% to 38% of soybean powder, 3% to 6% of mulberry branch powder, 1% to 10% of starch, 1% to 3% of compound VB1, 1% to 3% of VC1, 1% to 4% of citric acid, 1% to 10% of xylitol, and 1% to 10% of D-sorbitol. The artificial feed for silkworm has the advantages that body weight and new molting rate of 3-instar silkworms fed with the artificial feed can be increased, water loss rate of the artificial feed is lowered, growth of molds can be suppressed, and good conditions are provided for silkworm breeding.

The invention discloses a drag reduction object which comprises the following components in percentage by weight: 5 to 35 percent of parting agent, 5 to 40 percent of dispersing agent and over 30 percent of poly-alpha-olefin or copolymer of the poly-alpha-olefin, wherein the parting agent is selected from one or more of a powdered inorganic mineral material, organic wax, solid alcohol, stearate and fatty alcohol-polyoxyethylene ether; and the dispersing agent is selected from one or more of water, alcohol, cellosolve, polyether polyol, fatty alcohol-polyoxyethylene ether, alkyl phenyl polyoxyethylene ether, D-sorbitol polyoxyethylene ether, fatty glyceride and fatty acid. The invention also discloses a method for preparing the drag reduction object. The poly-alpha-olefin or copolymer of the poly-alpha-olefin content in the drag reduction object is up to over 30 percent, so that the transportation cost is reduced; a drag reduction effect can be effectively achieved; and the drag reduction rate is nearly 30 percent. The preparation process is finished at room temperature; and steps of refrigerating at low temperature, smashing, grinding and the like are eliminated.

The invention discloses a method which enhances glycometabolism efficiency of Ketogulonogeniumvulgarum, increases the number of bacteria, greatly shortens the incubation period of 2-KGA (2-keto-L-gulonic acid) and improves the production efficiency by adding carbon sources including two-carbon units such as ethyl alcohol, acetaldehyde and acetic acid as well as six-carbon units such as D-sorbitol, D-mannitol and D-mannose which facilitates utilization of Ketogulonogeniumvulgarum in a mixed fermentation process of a vitamin C two-step fermentation method according to research results of Ketogulonogeniumvulgarum metabolic network analysis. In a 5L fermentation tank, the period can be shortened by 14.04%, and the yield is increased by 3.40 %. According to another application, L-sorbose is taken as a carbon source by reducing Ketogulonogeniumvulgarum, so that the efficiency for converting L-sorbose into 2-KGA is also improved. According to the method, the production process is advanced, the raw material cost is low, and the method is suitable for large-scale industrial production and is improvement and promotion of vitamin C preparation technology with a biological fermentation method in about forty years of China; and besides, harmful substance emission in a production process is prevented, pollution and public hazard to the ambient environment are avoided, and environment protection requirements are met.

The invention discloses a Gluconobacter oxydans engineering bacterium for producing vitamin C synthesis intermediate sorbic ketone and a construction method and application thereof, and belongs to the field of genetic engineering. By means of the genetic engineering technique, a sorbose dehydrogenase gene (sdh) derived from common ketogenic base Ketogulonigenium vulgare is cloned onto Gluconobacter oxydans to obtain the G. oxydans engineering bacterium for producing the sorbic ketone by utilizing sorbitol. G. oxydans WSH-003 which is provided by Jiangsu Jiangshan Pharmaceutical Co., Ltd is a fermented industrial strain obtained in a first step of a two-step fermentation method for producing 2-keto-L-gulonic acid (2-KLG). The sdh is cloned into the G. oxydans so that conversion from D-sorbitol to the vitamin C synthesis intermediate sorbic ketone is achieved, the foundation for further constructing the fermented industrial strain in one step to produce the direct precursor 2-KLG of vitamin C is laid, and the yield of the sorbic ketone is as high as 72g/L. Therefore, the Gluconobacter oxydans engineering bacterium has good application prospects.

The invention discloses a soil remediation method for removing heavy metal lead. According to the method, the biological fermentation characteristic of gluconobacter oxydans is creatively utilized; lactonization reaction is conducted in the gluconobacter oxydans in presence of D-sorbitol and various sorts of nutritional ingredients inherent in soil, and finally L-ascorbic acid (vitamin C) is produced through fermentation; and then the L-ascorbic acid can be bonded with the heavy metal lead to produce non-toxic inorganic salt with the density being obviously larger than that of soil particles, and the heavy metal lead can be separated and removed from the soil through vibration sorting operation. Meanwhile, by the adoption of the L-ascorbic acid produced in the way that the D-sorbitol participates in biological fermentation reaction, the cost is far lower than that of adding L-ascorbic acid into the soil directly, and the material cost of soil remediation treatment can be greatly reduced.

The invention belongs to the technical field of medicine, and discloses a Relinqing chewable tablet and a preparation method thereof. The Relinqing chewable tablet is prepared from polygonum capitatum, mannitol, D-sorbitol sorbitol, stevioside, citric acid, magnesium stearate and ethanol. The preparation method comprises: taking a polygonum capitatum crude medicine, and adding water into the polygonum capitatum crude medicine for decoction for two times, wherein the decoction is performed for 1 to 2 hours each time and 12 to 14 times of water is added each time; mixing decoction solution, filtering the mixture, and performing vacuum concentration on filtrate to obtain dense ointment with the relative density of between 1.35 and 1.38 (60 DEG C); drying the dense ointment, and crushing the obtained product into fine powder; adding the mannitol, the D-sorbitol sorbitol, the stevioside and the citric acid into the fine powder, and uniformly mixing the materials; adding the ethanol as an adhesive to prepare particles; and adding the magnesium stearate to press the particles into tablets, and encapsulating film coats to obtain the Relinqing chewable tablet. As calculated by quercetin, the weight of the polygonum capitatum in each tablet is required to be not less than 0.1 milligram. The Relinqing chewable tablet has the advantages of good mouthfeel, quick medicine release, convenient taking, convenient carrying, stable quality, simple process and easy industrial production on a large scale.

The invention discloses a Gluconobacter oxydans gene engineering bacteria for producing 2-KLG and its application. According to the invention, by means of a genetic engineering technology, sorbose dehydrogenase (SDH) and sorbosone dehydrogenase (SNDH) genes derived from Ketogulonigenium vulgare are connected by a connecting peptide and then expressed in Gluconobacter oxydans so as to obtain G. oxydans engineering bacteria for high efficiency production of 2-KLG. The G. oxydans is a strain commonly used in a first step fermentation process during two-step fermentation production of 2-KLG. The expression of sdh and sndh genes in G.oxydans can dissolve the dependence problem of small bacteria on associated bacteria, thus realizing direct conversion from D-sorbitol to 2-KLG, and simplifying the vitamin C production process. With a 2-KLG yield of 32.4g/L, the Gluconobacter oxydans gene engineering bacteria has very good application prospects.

The invention concerns improved sugar-free products, their production and use, in particular, coated products, their production and use. The products are characterized by their content in enriched mixtures of 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM) and 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS).

The invention relates to a composition for improving the glossiness of polypropylene and reducing the haze of polypropylene and application thereof.The composition is prepared from two different types of transparent polyolefin nucleating agents 1,3:2,4-2-bi-(p-chlorophenyl methylene)-D-sorbose and 1,3:2,4-bi(3,4-dimethyl benzylidene)-D-sorbitol, can unexpectedly improve the glossiness of the polypropylene and reduce the haze of the polypropylene, meanwhile can effectively reduce the injection and extrusion temperatures of the polypropylene and achieves the effects of improving the transparency quality of polypropylene products and reducing the production cost.

A method of effecting lysis of acid-fast bacteria, comprising heating acid-fast bacteria in a liquid containing a non-ionic surfactant at a temperature of below the boiling point of the liquid. This method enables accomplishing secure lysis of acid-fast bacteria in a simple manner within a short period of time without the use of special apparatus and agent and enables extracting genes. The heating is preferably conducted at 96° C. for 10 min. As the nonionic surfactant, use can be made of a d-sorbitol fatty acid ester, a polyoxyethylene glycol sorbitan alkyl ester, a polyoxyethylene glycol p-t-octylphenyl ether or the like. The pH value of the liquid is preferably 8, and the liquid preferably contains EDTA. It is also preferred that before the heating, the acid-fast bacteria be treated with lipase.

The invention relates to a novel use of a mixture of 6-O-alpha-D-glucopyranosyl-D-sorbitol and 1-O-alpha-D-glucopyranosyl-D-mannitol as a bifidogenic prebiotic optionally containing a probiotic, to be used as or for producing a food item, semi-luxury food, fodder, or a medicament. Said medicament is used for the treatment and/or prevention of intestinal diseases such as chronic inflammatory intestinal diseases, intestinal cancer, bacterial intestinal infections, among other things.

The invention discloses a preparation method for a sandwich doughnut cake, and belongs to the field of preparation of doughnut cakes. The sandwich doughnut cake is prepared from the following raw materials in parts by mass: 22-23 parts of medium-strength wheat flour, 19-22 parts of white granulated sugar, 4-6 parts of water, 18-21 parts of refined vegetable oil, 25-26 parts of fresh eggs, 5-6 parts of corn starch, 1-2 parts of edible salts, 0.5-0.8 part of double-effect baking powder, 0.1-0.2 part of citric acid, 0.05-0.15 part of edible flavor, 2-6 parts of Custard cream, 5-6 parts of coating chocolate, 0.2-0.5 part of chocolate cream, 0.04-0.06 part of a d-sorbitol solution, 0.04-0.05 part of glycerol, 0.04-0.05 part of xanthan gum and 0.10-0.15 part of a cake emulsifier. A preparation method for the sandwich doughnut cake comprises the following steps: preparing the raw materials and mixing the raw materials, fermenting flour pulp, slip-casting and molding the fermented flour pulp, roasting the fermented flour pulp, carrying out core casting on the roasted flour pulp, de-molding and cooling the flour pulp to obtain a cake, forming patterns on the coating of the cake, and packaging and warehousing the cake. The preparation method further comprises preparing coating chocolate. The sandwich doughnut cake adopts various formulas, and is rich in nutrient, is fine in classifying in a preparing process, steps are smooth, and the operation is easier.

The invention relates to a transparent photocatalyst emulsion of composite metal ion doped with nano TiO2, which is characterized in that the emulsion comprises the following components by weight proportion: nano TiO2, 2.1 to 20 percent of metal salt containing lanthanum, cerium and vanadium, 1 to 10 percent of tween, arlacel, D-sorbitol or OP emulsifier and the residual amount of water. The mole ratio of the metal salt containing lanthanum, cerium and vanadium and titanium is 3.0 to 10 percent. The invention adopts inorganic salts with low price of titanium tetrachloride, lanthanum nitrate, cerous sulfate and metavanadic acid, and the like, adopts low-temperature complexation-control hydrolysis reaction to prepare the transparent photocatalyst emulsion of composite metal ion doped with nano TiO2, leads the materials to form more doping levels, thus widening the response interval of spectrum; the invention has the biggest advantages that sunlight or a fluorescent light is utilized directly to realize complete degradation to the organic pollutants of formaldehyde, benzene, dye, pesticide, microorganism and the like, and the speed and efficiency of degradation of organic matter by photocatalysis is improved, thus realizing the purification to environment.

The invention discloses a stuffed baking pita cake and a preparation method thereof, which comprises a cake embryo and stuffing. The cake embryo comprises, by weight, 30-50 parts of eggs, 15-30 parts of white sugar, 20-35 parts of pastry flour, 0.5-5 parts of edible vegetable oil, 1-5 parts of powdered milk, 1-10 parts of exclusive modifying agent for baking pita cakes, 0.5-3 parts of cake oil, 1-5 parts of D-sorbitol solution, 1-3 parts of glycerol, 0.1-0.5 part of salt, 0.01-0.3 part of preservative, 0.02-0.07 part of citric acid and 0.05-0.5 part of edible flavor. The preparation method comprises the steps of premixing raw materials, stirring, dispensing, distributing pulp, baking cakes, stripping and cooling, cutting the cakes, injecting the stuffing and compression moulding and the like. According to the stuffed baking pita cake, the style of the cake is novel, moreover, the cake is filled with different flavors of jam, greatly enriching its taste and nutrition, the cake tastes moist and elastic, storage life can be up to one month, and the cake can attract consumers easily and has a broad market prospect.

The invention discloses a method for reinforcing a hemi-cellulose membrane by utilizing CNCC (Cationic Nanocrystalline Cellulose). The method comprises the following steps: firstly, carrying out cationic modification on NCC (Nanocrystalline Cellulose) obtained through hydrolysis of cotton microcrystalline cellulose, thus obtaining the CNCC; secondly, designing a hemi-cellulose/D-sorbitol/NCC dispersion system according to a certain mass proportion, and magnetically stirring at a high speed for a certain time, thus obtaining an aqueous-phase mixed system with good dispersibility; finally, taking and pouring a certain amount of hemi-cellulose/D-sorbitol/NCC dispersion solution to a polytetrafluoroethylene die, and carrying out air blast drying, thus preparing the hemi-cellulose membrane reinforced by the CNCC. According to the method disclosed by the invention, the performance of the hemi-cellulose membrane is improved by fully utilizing the mechanical performance and the thermal stability of the CNCC; the technology is simple, industrialization is easy, the membrane forming performance is good, the strength is high, and a formed membrane has good barrier performance and good water resistance.