Melatonin soft capsules and preparation method thereof

A technology for melatonin and soft capsules is applied in the field of formulation and preparation of melatonin soft capsules, which can solve the problems of decreased water content of the capsule shell, hardened capsule shell, unfavorable digestion and absorption, etc., and achieves the effect of beautiful appearance

Inactive Publication Date: 2011-02-09
杭州海王生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1) Because melatonin is soluble in water, the shell of the soft capsule contains water, so melatonin will partially migrate into the capsule shell after a period of time. The amount of melatonin added to each capsule is mostly in milligrams, so it is very difficult It is easy to cause instability in the measured value of melatonin content in the content
[0007] 2) It is also because melatonin is soluble in water, so it is easier to absorb the water in the capsule shell, resulting in a decrease in the water content of the capsule shell, causing the product to be placed for a period of time, and the capsule shell becomes brittle, hard and disintegrated due to the decrease in water content The time limit is extended, and it is not conducive to the digestion and absorption of the product after taking it

Method used

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  • Melatonin soft capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Preparation of content: Weigh 142.50g of melatonin, slowly add 1460g of polyethylene glycol 400, stir while adding, until the melatonin is completely dissolved, add 575g of glycerin, stir and mix well, then add 10320g of polyethylene glycol Alcohol 400, after stirring and mixing, grind twice with a colloid mill, pass through a 100-mesh sieve, cover and place it for later use.

[0032] 2) Glue solution preparation: first add 41.6Kg of water, 24Kg of glycerin (2Kg is reserved for coloring), and 10.41Kg of sorbitol solution into the glue tank in proportion, heat and stir. Add 52Kg of gelatin when heated to a certain temperature of 65-75°C, and continue to stir. After the gelatin is melted in hot water and mixed with sorbitol liquid, glycerin, and purified water to form a uniform glue, vacuumize while stirring until there are no bubbles. .

[0033] Weigh 10.4g of tartrazine, 260g of titanium dioxide, and mix with 2kg of glycerin reserved for gelatinization, add to a col...

Embodiment 2

[0043] 1) Preparation of content: Weigh 81.4g of melatonin, slowly add 960g of polyethylene glycol 400, and stir while adding, until the melatonin is completely dissolved, add 600g of propylene glycol, stir and mix, and then add 10856g of polyethylene glycol Alcohol 400, after stirring and mixing, grind twice with a colloid mill, pass through a 100-mesh sieve, cover and place it for later use.

[0044] 2) Glue solution preparation: first add 41Kg of water, 25.2Kg of glycerin (1Kg is reserved for coloring), and 10.44Kg of sorbitol solution into the glue tank in proportion, heat and stir. Add 52Kg of gelatin when heated to a certain temperature of 65-75°C, and continue to stir. After the gelatin is melted in hot water and mixed with sorbitol liquid, glycerin, and purified water to form a uniform glue, vacuumize while stirring until there are no bubbles. .

[0045] Weigh 2g of Brilliant Blue, mix with 1Kg of glycerin reserved for gelatinization, add to a colloid mill and grind e...

Embodiment 3

[0049] 1) Preparation of content: Weigh 142.50g of melatonin, slowly add 1460g of polyethylene glycol 400, and stir while adding, until the melatonin is completely dissolved, add 450g of glycerin and 200g of propylene glycol, stir and mix, and then add 6310g Polyethylene glycol 400 and 3935g polyethylene glycol 600, after stirring and mixing, grind twice with a colloid mill, pass through an 80-mesh sieve, cover and store, and set aside.

[0050] 2) Glue solution preparation: first add 41.6Kg of water, 24.5Kg of glycerin (1.5Kg is reserved for coloring), and 10.41Kg of sorbitol solution into the glue tank in proportion, heat and stir. Add 52Kg of gelatin when heated to a certain temperature of 65-75°C, and continue to stir. After the gelatin is melted in hot water and mixed with sorbitol liquid, glycerin, and purified water to form a uniform glue, vacuumize while stirring until there are no bubbles. .

[0051] Weigh 400g of cocoa shell pigment, 4.2g of brilliant blue, 0.3g of ...

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Abstract

The invention discloses melatonin soft capsules and a preparation method thereof. The contents of the soft capsules serving as the product comprise melatonin, polyethylene glycol and stabilizer in a weight ratio of 1:60-360:2-12, wherein the soft capsule shell comprises gelatin, pure water, glycerol, D-sorbitol solution, titanium dioxide and lemon yellow in the weight ratio of 1.0:0.76-0.85:0.45-0.55:0.15-0.25:0.002-0.006:0.00008-0.00024; the product is the melatonin soft capsules with polyethylene glycol as medium; a certain proportion of stabilizer is added into the contents; and the components such as the D-sorbitol solution and the like are added into the capsule shell. The product can solve the problems that the melatonin in the contents of the soft capsules available on the current market is easy to migrate, the capsule shell is easy to become hard and crisp and difficult to break down after being placed for a long time and the like.

Description

technical field [0001] The invention belongs to the technical field of melatonin soft capsules, and in particular relates to a formula and a preparation method of melatonin soft capsules. technical background [0002] Melatonin, also known as pineal gland, is an indoleamine hormone secreted by the pineal gland of mammals and humans at night. Its chemical name is N-acetyl-5-methoxytryptamine. Molecular formula is C 13 h 16 N 2 o 2 , has good light and heat stability, slightly soluble in water, easily soluble in hot water and propylene glycol, soluble in aqueous ethanol, acid, alkali and salt water. The amount of melatonin secreted daily is extremely small, but its effect is extremely powerful, and it has a wide range of physiological and pharmacological effects. Studies have shown that melatonin has various physiological functions such as adjusting the biological clock, inducing sleep, and regulating the endocrine system. [0003] The sleep activity of the human body is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K9/48A61K47/10A61K47/04A61K47/42A61K31/4045A61P25/20A61K47/26
Inventor 刘勇李文霞戴晶晶柏金霞朱妙飞上官海燕郭靖赵耘
Owner 杭州海王生物工程有限公司
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