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Vitamin C effervescent tablet

A vitamin and effervescent tablet technology, applied in the field of effervescent tablets and vitamin C effervescent tablets, can solve the problems affecting the stability of effervescent tablets, long drying and dehydration time, and many process steps, so as to improve material stability and reduce Effect of material pollution and process flow reduction

Inactive Publication Date: 2018-06-15
SHANDONG TIANLI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Effervescent tablets are generally wet granulated by acid and alkali alone, and then mixed with other raw materials for tablet compression. This production method has many process steps, and the moisture content must be controlled to a relatively low level after wet granulation, otherwise it will The tableting process sticks and punches, and causes acid-base reaction, which affects the stability of the effervescent tablet during storage, and the drying and dehydration time is longer, resulting in higher energy consumption

Method used

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  • Vitamin C effervescent tablet
  • Vitamin C effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] According to 4g / tablet, prepare 10000 pieces by weight, and the quality of each component is:

[0015] Vitamin C 300g, anhydrous citric acid 7000g, sodium bicarbonate 9000g, sodium caseinate 100g, sunset yellow aluminum lake 5g, PEG6000 1000g, orange flavor 100g, steviol glycoside 60g, α crystal mannitol 8974g, β mannitol granules 13461g .

[0016] The preparation method comprises the following steps:

[0017] (1) Vitamin C, anhydrous citric acid, sodium bicarbonate, sodium caseinate, PEG6000, α-crystalline mannitol and β-mannitol granules are respectively passed through a 100-mesh sieve for later use.

[0018] (2) Accurately weigh various raw and auxiliary materials according to the formula, mix and press into tablets.

[0019] Detection method:

[0020] Hardness: Measured by SY-6D tablet four-purpose tester, take 10 tablets for measurement, and calculate the average value.

[0021] Friability: measured by SY-6D four-purpose tester for tablets, drum diameter Drum...

Embodiment 2

[0024] According to 4g / tablet, prepare 10000 pieces by weight, and the quality of each component is:

[0025] Vitamin C1000g, anhydrous citric acid 6600g, sodium bicarbonate 8000g, sodium caseinate 150g, sunset yellow aluminum lake 10g, PEG6000 1000g, orange flavor 150g, steviol glycosides 200g, α-crystalline mannitol 11545g, β-mannitol granules 11545g .

[0026] The specific preparation and detection methods are the same as in Example 1.

Embodiment 3

[0028] According to 4g / tablet, prepare 10000 pieces by weight, and the quality of each component is:

[0029] Vitamin C 1000g, anhydrous citric acid 6600g, sodium bicarbonate 8000g, sunset yellow aluminum lake 10g, PEG60001000g, orange flavor 150g, steviol glycoside 200g, α crystal mannitol 11545g, β mannitol granule 13045g.

[0030] The specific preparation and detection methods are the same as in Example 1.

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Abstract

The present invention relates to an effervescent tablet, and particularly relates to a vitamin C effervescent tablet. The invention belongs to the technical field of health food tablet formulation. Vitamin C, one of the essential vitamins of the human body, has a preventive effect on many diseases. Vitamin C can also be used in combination with many other drugs in the treatment of certain diseases. Effervescent tablet is a novel tablet developed and applied abroad in recent years, and the effervescent tablet is usually prepared by acid and alkali separate wet granulation, followed by being mixed with other raw materials for tablet compressing. In order to shorten the production process and further improve the product stability, the invention adopts the mixed use of alpha- and beta-crystalform D-mannitol, which reduces the fragility of the tablets on the basis of ensuring the effervescent effect of the tablets. The formula of the invention is suitable for the direct tablet compressingprocess, free of the addition of water or other wetting agents in the production process and capable of reducing the occurrence of material pollution, improving the production efficiency, reducing theprocess flow and decreasing and reducing the energy consumption. In addition, the addition of sodium caseinate can improve the effervescent effect of the tablets.

Description

technical field [0001] The invention relates to an effervescent tablet, in particular to a vitamin C effervescent tablet, which belongs to the technical field of health food tablet formula. technical background [0002] As one of the essential vitamins for the human body, vitamin C can participate in the metabolism of amino acids, the synthesis of neurotransmitters, the synthesis of collagen and tissue interstitium, reduce the permeability of capillaries, promote iron absorption, and improve cholesterol metabolism , antihistamine, enhance immunity, etc. Taking it can increase the body's resistance and prevent the invasion of cold viruses. According to related data, vitamin C is deficient in various degrees in various populations. When the body has some minor problems, it should be timely supplemented with appropriate amount of vitamins and minerals to improve nutritional deficiencies, especially for middle-aged and elderly people. Vitamins have a preventive effect on many ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L29/30A23P10/28
CPCA23L29/37A23L33/15A23P10/28A23V2002/00A23V2200/30A23V2250/032A23V2250/708A23V2250/262A23V2250/6418
Inventor 庄祎王乔隆陈平平郑秀宁刘敏
Owner SHANDONG TIANLI PHARMA
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