Thymus penta peptide slow releasing micro ball and its preparing method

A slow-release microsphere and thymus technology, which is applied in pharmaceutical formulations, peptide/protein components, medical preparations containing active ingredients, etc., can solve problems such as limiting clinical application and market development, patient inconvenience, poor compliance, etc.

Active Publication Date: 2006-01-04
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

TP-5 treats a wide range of diseases, and the medication time ranges from 1 to 24 months. Therefore, long-term frequent injections are required clinically, which brings a lot of inconvenience to patients, poor compliance, and extremely inconvenient clinical use and treatment. Significantly limits the clinical application and market development of the drug

Method used

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  • Thymus penta peptide slow releasing micro ball and its preparing method
  • Thymus penta peptide slow releasing micro ball and its preparing method
  • Thymus penta peptide slow releasing micro ball and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0017] Weigh 1000mg PLGA (polymerization ratio=50:50, molecular weight 18000), dissolve it in 2ml dichloromethane, weigh 40mg-TP-5 and dissolve it in 400μl distilled water. Preparation concentration is 20ml of the PVA aqueous solution of 3% and the PVA aqueous solution 300ml of 0.3% of concentration. First move the TP-5 solution into the dichloromethane solution that is dissolved with PLGA, place it on an emulsifying disperser under ice bath conditions at a high speed (22000rpm) for 20 seconds, and then transfer the prepared W / O emulsion to 20ml Concentration is 3% PVA solution, put on the emulsifying disperser with the rotating speed of 6000rpm, milk evenly for 1 minute, get W / O / W type double emulsion, move into 300ml 0.3% PVA solution, place on the mechanical stirrer Stir at 500 rpm for 3 hours, centrifuge, collect the obtained microspheres, wash with distilled water for several times, then collect by centrifugation, and freeze-dry to obtain the final product.

[0018] The ...

experiment example 2

[0020] Weigh 600mg PLGA (polymerization ratio=50:50, molecular weight 18000), dissolve in 2ml dichloromethane, weigh 28mgTP-5 and dissolve in 400μl distilled water, prepare 20ml of 3% PVA aqueous solution and 0.3% PVA aqueous solution 300ml. First move the TP-5 solution into the dichloromethane solution that is dissolved with PLGA, place it on an emulsifying disperser under ice bath conditions at a high speed (22000rpm) for 20 seconds, and then transfer the prepared W / O emulsion to 20ml Concentration is 3% PVA solution, put on the emulsifying disperser with the rotating speed of 6000rpm, milk evenly for 1 minute, get W / O / W type double emulsion, move into 300ml 0.5% PVA solution, place on the mechanical stirrer Stir at 500 rpm for 3 hours, centrifuge to collect the obtained microspheres, wash with distilled water several times, then collect by centrifugation, and freeze-dry.

[0021] The particle size of the obtained microspheres is 1-40 μm, and the average particle size is 25...

Embodiment 3

[0023] Weigh 1000mg PLGA (polymerization ratio=50:50, molecular weight 18000), dissolve it in 2ml dichloromethane, weigh 80mg TP-5 and dissolve it in 400μl distilled water, and prepare 20ml PVA aqueous solution with a concentration of 2% and a concentration of 0.5% 300ml of PVA aqueous solution. First move the TP-5 solution into the dichloromethane solution that is dissolved with PLGA, place it on an emulsifying disperser under ice bath conditions at a high speed (22000rpm) for 20 seconds, and then transfer the prepared W / O emulsion to 20ml Concentration is 3% in PVA solution, put on emulsifying disperser with the rotating speed of 6000rpm, milk evenly for 1 minute, then move the obtained W / O / W type double emulsion into 300ml 0.5% PVA solution, place on a mechanical stirrer to Stir at 500 rpm for 3 hours, centrifuge to collect the obtained microspheres, wash with distilled water several times, then collect by centrifugation, and freeze-dry.

[0024] The particle size of the o...

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Abstract

The present invention discloses a kind of slowly releasing thymus penta peptide microballoon and its preparation process. The thymus penta peptide microballoon consists of thymus penta peptide, biodegradable medicinal polymer material and emulsifying stabilizer. It may be prepared through emulsifying dispersion process, solvent volatilizing process, spray drying process or lower temperature spray extracting process. The thymus penta peptide microballoon with biodegradable medicinal polymer material may be released slowly for several days or even several months, resulting in obviously medicine taking times and being favorable to clinical treatment.

Description

technical field [0001] The invention relates to a slow-release microsphere of thymopentin (TP-5). The microsphere is composed of drug thymopentin, biodegradable medicinal polymer material, emulsification stabilizer and emulsification stabilizer, and can be prepared by emulsification dispersion method, solvent evaporation method, spray drying method or low temperature spray extraction method. The microspheres prepared by the patented method can slowly release thymopentin, and the sustained release period can last for several days or several months, which can obviously reduce the frequency of taking medicine and is more beneficial to clinical treatment. Background technique [0002] Thymic insufficiency, chronic viral infection, and proliferative changes are related to the occurrence of autoimmunity. When the function of the thymus itself is insufficient or the immune system dependent on the thymus has obvious primary or secondary defects, and its own regulation is not enough...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K9/16A61P37/02A61P1/16A61P31/14A61P29/00A61P19/02A61P11/06A61P1/02A61P35/00
Inventor 刘玉玲胡俊
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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