Prescription and preparation method of thymopeptide-5 injection

A technology for injection and thymus, which is applied in the field of thymopentin injection, can solve problems such as increasing drug pollution, and achieve the effects of convenient preparation and good stability

Inactive Publication Date: 2012-03-21
双鹤药业(海南)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is currently on the market in the form of injection ampoules in foreign countries, but in China it appeared in the market in the form of freeze-dried powder injections before 2006. As a freeze-dried preparation, it needs to be dissolved when used, which increases the risk of drug contamination. Chance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Thymopentin 1mg

[0020] Sodium chloride 9g

[0021] Sodium bicarbonate

[0022]

[0023] Make 1000 sticks

[0024] Weigh the prescribed amount of sodium chloride, add 1000ml of water for injection, stir to dissolve, adjust the pH to 6.0-7.0 with a pH regulator, add 0.1% activated carbon (w / v), stir and absorb for 30 minutes, filter, and dilute the filtrate with water for injection To 1200ml, prepare 0.75% sodium chloride solution for use; Measure 1000ml sodium chloride solution, add the prescribed amount of thymopentin, stir to dissolve, sterilize and filter with 0.22μm filter membrane, and fill.

Embodiment 2

[0026] Thymopentin 1~10mg

[0027] Mannitol 10.8g

[0028] Sodium hydroxide amount

[0029]

[0030] Make 1000 sticks

[0031] Weigh the prescription amount of mannitol, add 1000ml of water for injection, stir to dissolve, adjust the pH to 6.0-7.0 with a pH regulator, add 0.1% activated carbon (w / v), stir and absorb for 30 minutes, filter, and dilute the filtrate with water for injection to 1200ml, prepared into 0.75% mannitol solution, ready to use; Measure 1000ml of mannitol solution, add the prescribed amount of thymopentin, stir to dissolve, sterilize and filter with 0.22μm filter membrane, and fill.

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Abstract

The invention provides a prescription and a preparation method of a thymopeptide-5 injection for treating chronic disease toxic hepatitis, tumor, and other immunity diseases. The injection is prepared through taking thymopeptide-5 as an active ingredient, and adding injection-use auxiliary materials and injection-use water. The invention aims to overcome the shortages of pharmaceutical preparations taking thymopeptide-5 as the active ingredient, and provides the prescription and the preparation method of the thymopeptide-5 injection. The thymopeptide-5 injection provided by the invention has stable stability and convenience in preparation, reduces contamination rate during the use of medication, provides great convenience to the use of the medication, and improves the safety of the medication and adaptability of patients.

Description

Technical field: [0001] The invention relates to a prescription and preparation method of thymopentin injection for treating chronic viral hepatitis, tumors and other immune diseases. Background technique: [0002] Thymopentin (Thymopentin), its chemical name: N-[N-[N-[N α -L-Arginyl-L-Lysyl]-L-α-Aspartyl]-L-Valyl]-L-tyrosine is the amino acid at positions 32 to 36 of thymopoietin II Fragment, its main physiological function is to induce and promote the differentiation, maturation and activation of T lymphocytes and its subgroups, adjust the ratio of T lymphocytes, and make CD 4 + / CD 8 + It tends to be normal, has a two-way regulatory effect of regulating and enhancing human cellular immune function, can promote the maturation of T lymphocytes in peripheral blood after mitogen activation, and increase T cells in various antigens or various lymphokines after mitogenic activation ( For example, the secretion of α, γ interferon, interleukin 2 and interleukin 3) increases the level ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K9/08A61P1/16A61P31/14A61P31/20A61P35/00A61P37/00
Inventor 魏雪纹李强
Owner 双鹤药业(海南)有限责任公司
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