Recombinant thymus pentapeptide structural analogs, its production and use

A technology similar in structure to thymosin, applied in the field of genetic engineering, can solve problems such as the inability to realize the efficient preparation of cyclic peptides, and achieve the effect of low cost and high efficiency
CN1982331AInactive Publication Date: 2007-06-20广州达信生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
广州达信生物技术有限公司
Publication Date
2007-06-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

Recombinant thymus pentapeptide structural analogs, its production, expression and use for preparing related immune diseases medicines are disclosed. The structural formula is cyclo-(Cys-Arg-Lys-Asp-Val-Tyr-), and it consists of Cys-guided circular thymic peptide and 6 amino acids. It has better biological activity and stability.
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Description

technical field

[0001] The invention relates to the technical field of genetic engineering, in particular to a recombinant thymosin analogue and a preparation method thereof, and the application of the recombinant thymosin analogue in medicine for treating immune-related diseases. Background technique

[0002] U.S. Patents (U.S.Pat.Nos.4,190,646 and U.S.PaT.Nos.4,261,886) disclose artificially synthesized pentapeptides that have the same activity as human natural thymosin II (composed of 74 amino acids), and the sequence is H-ARG-LYS -ASP-VAL-TYR-OH, known as thymopentin (thymopentin or thymopoietin, TP); US patents (U.S. Pat. Nos. 4,002,740 and 4,077,949) reveal that thymopentin can selectively activate T cell differentiation, 1978 M.E. Weksler and others published an article in "Japanese Applied Medicine", claiming that thymopentin has a significant immune regulation function and has great medical application value.

[0003] Since then, a number of patents in the United S...

Claims

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