Abuse resistant drug formulation

a drug formulation and drug technology, applied in the direction of biocide, microcapsules, drug compositions, etc., can solve the problems of significant side effects, inability to meet the needs of patients, so as to reduce the amount of drug abus
US20080069891A1Inactive Publication Date: 2008-03-20CIMA LABS +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CIMA LABS
Publication Date
2008-03-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat / wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of the filing date of U.S. Provisional Patent Application Nos. 60 / 845,128 filed Sep. 15, 2006, 60 / 845,127 filed Sep. 15, 2006, 60 / 845,126 filed Sep. 15, 2006, 60 / 845,151 filed Sep. 15, 2006, and 60 / 850,456 filed Oct. 10, 2006, the disclosures of which are hereby incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Some prescription drugs provide a controlled release of the active pharmaceutical ingredient (“API”) that they are intended to deliver. Controlled release can be a delayed release such as an enteric release in the intestines. It can be an extended release where release begins immediately or shortly after ingestion and continues, either at a constant rate or in some pattern, over an extended period of time, usually from about 6 to about 24 hours. Often this is accomplished using a controlled release coating. Not only are controlled release dosage forms, and especially extended rele...

Claims

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