Radial shape of polymer compound containing iodine, preparation method thereof, and ct contrast medium composition containing same

Abstract

The present invention relates to a radial shape of a polymer compound containing iodine capable of being used as an active ingredient of a CT contrast medium, a preparation method thereof, and a contrast medium composition containing the same. According to the present invention, the radial shape of the polymer compound containing iodine has a remarkably enhanced contrast effect retention time compared with a conventional low molecular weight contrast medium compound containing iodine. In addition, the polymer compound containing iodine forms a protective film by encompassing a compound containing iodine substituted near the surface of a central nucleus, which leaves room for causing various kinds of abnormal reactions with toxicity, with a relatively long biocompatible polymer chain layer, thereby preventing the exposure thereof to external environments to reduce in vivo toxicity, preventing the rapid absorption due to a macrophage to extend in vivo circulation time, and allowing the polymer compound containing iodine to be discharged from the body after an adequate time has passed since an in vivo injection. Further, the preparation method and the purification method of the polymer compound containing iodine are very simple, thereby enabling mass production in a high yield and at low costs, the polydispersity is very low, thereby providing high reproducibility in the preparation and effects, and all of the structures of the prepared radial shape of the polymer compound containing iodine comprise a covalent bond, thereby being structurally very stable, and thus the polymer compound containing iodine can be useful for the preparation of a CT contrast medium.

Description

technical field [0001] The present application relates to an iodine-containing radial macromolecule used as an active component of a computed tomography (CT) contrast medium, a preparation method thereof, and a CT contrast medium composition comprising the radial macromolecule. Background technique [0002] Computed tomography (CT, Computed Tomography) is a photographic technique in which X-rays in different directions are used to irradiate the target area of ​​the human body, and the transmitted X-rays are collected by a detector, and then reconstructed by a computer through mathematical techniques The difference between the X-ray absorption for that region. That is, it is an imaging technique that uses computer programming to create a three-dimensional image by recombining multiple two-dimensional x-ray pictures taken at various angles with a camera that can be rotated 360 degrees around the body. [0003] Thus, such x-ray based imaging generally focuses primarily on gene...

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Problems solved by technology

This may be due to the complex preparation of dendrimer-based iodine-containing CT contrast media involving many synthetic steps, relatively higher toxicity, and to a lesser extent the duration of contrast enhancement compared with small-molecule iodine-containing contrast agents. time, and relatively poor image quality (i.e., contrast enhancement) (Non-Patent Document 10 [W.Krause et al, Top.Curr.Chem.2000, 210, 261-308], Patent Document 3 [PCT / EP94 / 04245] , Patent Document 4 [PCT / EP96 / 02450], Patent Document 5 [PCT / FR92 / 01135], Patent Document 6 [PCT / EP94 / 648203], Patent Document 7 [PCT / EP95 / 730573], Patent Document 8 [PCT / EP95 / 78263], Non-Patent Document 11 [A.T.Yordanov et al, Nano Lett. 2002, 2, 595-599] and Non-Patent Document 12 [Y.Fu et al, Bioconjugate Chem. 2006, 17, 1043-1056])

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