Preparation of anemoside B4 for rectal mucosal administration and preparation method thereof

A technology of Pulsatilla saponins and rectal mucosa, which can be applied to medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of rectal mucosa drug delivery preparations that have not been reported yet.

Pending Publication Date: 2018-06-12
刘琦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no report of the rectal mucosal administration preparation of Pulsatilla saponin B4

Method used

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  • Preparation of anemoside B4 for rectal mucosal administration and preparation method thereof
  • Preparation of anemoside B4 for rectal mucosal administration and preparation method thereof
  • Preparation of anemoside B4 for rectal mucosal administration and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 A rectal gel of Pulsatilla saponin B4

[0088] prescription:

[0089]

[0090] Preparation:

[0091] Accurately weigh / measure each component according to the prescription; completely dissolve Pulsatilla saponin B4 in deionized water (magnetic stirring), and filter to obtain Pulsatilla saponin B4 aqueous solution; take Carbomer 941 and slowly add it to the Pulsatilla pulsatillae B4 aqueous solution During the process, stir for 20 minutes while adding until evenly mixed, then add glycerin and continue to stir for 3 minutes, finally triethanolamine, adjust the pH to 6-7, and stir to obtain the Pulsatilla saponin B4 hydrogel preparation, obtain 65ml of Pulsatilla saponin B4 The content is about 17.46mg / mL.

Embodiment 2

[0092] Example 2 A rectal gel of Pulsatilla saponin B4

[0093] prescription:

[0094]

[0095] Preparation:

[0096] The preparation method was the same as in Example 1, and a total of 80 mL of Pulsatilla saponin B4 hydrogel preparation was obtained, and the content of Pulsatillae saponin B4 was about 23.92 mg / mL.

Embodiment 3

[0097] Example 3 A rectal gel of Pulsatilla saponin B4

[0098] prescription:

[0099]

[0100] Preparation:

[0101] The preparation method was the same as in Example 1, and a total of 79 mL of Pulsatilla saponin B4 hydrogel preparation was obtained, and the content of Pulsatillae saponin B4 was about 8.73 mg / mL.

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Abstract

The invention relates to a preparation of anemoside B4 for rectal mucosal administration, comprising anemoside B4 and a pharmaceutically acceptable matrix; the preparation herein is selected from oneor two of rectal gel and rectal suppository. The invention also specifically provides rectal gel of anemoside B4, rectal suppository of anemoside B4, and their preparation methods. The preparation ofanemoside B4 for rectal mucosal administration provided herein requires less dosage than oral administration and has better effect under the same the dosage.

Description

technical field [0001] The invention belongs to the field of medicine and pharmaceutical preparations, and in particular relates to a new rectal mucosa administration preparation of Pulsatilla saponin B4 and a preparation method thereof. Background technique [0002] Pulsatilla chinensis (Bge.) Regel, a traditional Chinese medicine, is the dried root of Pulsatilla chinensis (Bge.) Regel, which is a commonly used traditional Chinese medicine. Its nature and flavor are bitter and cold, and it has the functions of clearing heat and detoxifying, cooling blood and stopping dysentery, drying dampness and killing insects, etc. Modern pharmacological research has found that Pulsatilla has more diverse activities, such as broad-spectrum antibacterial activity, anti-tumor, anti-inflammation, and enhancing the immune function of the body. [0003] Pulsatilla is rich in triterpenoid saponins. Pulsatilla saponin B4 belongs to lupine-type pentacyclic triterpene saponins, and its structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K9/06A61K31/704A61K47/32A61K47/14A61P13/12
CPCA61K47/14A61K47/32A61K9/0031A61K9/02A61K9/06A61K31/704Y02A50/30
Inventor 刘琦
Owner 刘琦
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