Rectal suppository LED (Light Emitting Diode) light source for photodynamic therapy of rectal cancers

Abstract

The invention discloses a rectal suppository irradiation light source for photodynamic therapy of rectal cancers, and belongs to a device for photodynamic therapy. A 635nm LED (Light Emitting Diode) light source, a lithium battery, a constant current control circuit and relevant circuits are packaged in a bullet-type rectal suppository having the length of about 3cm, the diameter of about 1cm and the front end slightly acute, wherein the packaging material is transparent epoxy resin adhesive. By such design, the overall light source can be placed in the rectum of a patient for photodynamic therapy, and is suitable for long-time and low-energy continuous irradiation. The photodynamic therapy process of rectal cancers is simplified, the compliance of patients is improved, the labor intensity of medical staffs is relieved, the cost of photodynamic therapy is reduced, the limitation of the photodynamic therapy space is broken, and patients can accept the therapy in clinics or at home. The light source involves in a scientific research experiment method as clinical reference data of rectal cancers.

Description

technical field [0001] The invention belongs to the field of light source design in photodynamic therapy research, and relates to a miniature LED rectal suppository light source that can be implanted in the rectum to realize long-term low-dose photodynamic therapy of rectal cancer. Background technique [0002] Photodynamic therapy (PDT) is the use of specific wavelengths of light to excite photosensitizers to undergo photodynamic reactions, that is, a series of photochemical reactions, and the reaction products (excited singlet oxygen molecules) have strong oxidation properties and can kill A new technology to treat the cells of surrounding lesions and achieve the purpose of treatment. [0003] The three elements of photodynamic therapy are photosensitizer, oxygen and light source. Traditional photodynamic therapy (acute photodynamic therapy, aPDT) irradiates the tumor with a relatively high-energy (50-500mW) laser for a short time (within 30 minutes) to stimulate the phot...

AI Technical Summary

Problems solved by technology

Rectal cancer is an indication for PDT, but the inflammatory reactions such as edema caused by conventional PDT treatment often cause side effects such as intestinal obstruction, which makes clinical treatment difficult, and mPDT can effectively solve this problem in principle, but currently relevant The research has not been reported yet, the main reason is the lack of suitable light source

Images