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Anal plug for gynecological pelvic inflammatory disease and preparation method thereof

A technology for inflammation of the anus and pelvic cavity, applied in the field of gynecological pelvic inflammatory disease anal suppository and its preparation, to achieve the effect of uniform suppository, good drug effect and uniform texture

Active Publication Date: 2017-12-15
刘红枚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Western medicine often uses physical therapy to treat chronic pelvic inflammatory disease, but it can only temporarily relieve symptoms. Patients often relapse after fatigue, menstruation, sexual life or anger. Therefore, there is no ideal treatment in Western medicine at present, and Chinese medicine has obvious advantages and characteristics in treating this disease

Method used

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  • Anal plug for gynecological pelvic inflammatory disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1.1 Preparation of comfrey soaked oil:

[0031] Weigh 28.0 g of comfrey, crush it into coarse powder, add corn oil with 10 times the amount of comfrey, ultrasonically extract at 40°C for 0.5 h, soak at room temperature for one week, and filter with multi-layer gauze to obtain comfrey soaked oil.

[0032] 1.2 Preparation of wild chrysanthemum extract:

[0033] Weigh 30g of wild chrysanthemum, extract 3 times with 70% ethanol under reflux, use 15 times the amount of solvent for the first time, extract for 1.5h, filter, use 12 times the amount of solvent for the second time, extract for 1 hour, and use 8 times the amount of solvent for the third time , extract for 1 h, filter respectively, combine the filtrates, concentrate under reduced pressure to 6 times the weight of the wild chrysanthemum flower g / ml for later use.

[0034] 1.3 Preparation of anal suppository for gynecological pelvic inflammatory disease:

[0035] a) Put sodium stearate in a mortar and grind it into...

Embodiment 2

[0041] 2.1 Preparation of comfrey soaked oil:

[0042] Weigh 35g of comfrey, crush it into a coarse powder, add corn oil with 12 times the amount of medicinal material, ultrasonically extract at 50°C for 1 hour, soak at room temperature for one week, and filter with multiple layers of gauze to obtain comfrey soaked oil.

[0043] 2.2 Preparation of wild chrysanthemum extract:

[0044] Weigh 30g of wild chrysanthemum, extract 3 times with 75% ethanol under reflux, use 12 times the amount of solvent for the first time, extract for 1 hour, filter, use 10 times the amount of solvent for the second time, extract for 1 hour, and use 9 times the amount of solvent for the third time, Extract for 0.5h, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of the wild chrysanthemum flower g / ml, and set aside.

[0045] 2.3 Preparation of anal suppository for gynecological pelvic inflammatory disease:

[0046] a) Put sodium stearate in a morta...

Embodiment 3

[0052] The physicochemical index of embodiment 1,2 is as follows:

[0053] 3.1 Traits

[0054] This product is a pale yellow bullet-shaped suppository with moderate hardness, uniform texture, fineness, smoothness, and complete and smooth appearance.

[0055] 3.2 Weight difference check

[0056]Take 10 capsules of the test product, accurately weigh the total weight, and after obtaining the average particle size, accurately weigh the weight of each capsule respectively, and compare the weight of each capsule with the marked grain weight (the suppository with no marked grain weight is compared with the average grain weight). Weight comparison), according to the regulations, no more than 1 grain exceeding the weight difference limit, and no more than 1 times the limit. It is determined that according to the weight difference limit ±7.5%, it meets the requirements of the Pharmacopoeia.

[0057] 3.3 Melting time limit inspection

[0058] Use a melting time limit detector to dete...

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Abstract

The invention discloses a gynecological pelvic inflammatory disease rectal suppository and a preparation method thereof. The suppository includes: 1.0-5.0g of span-40, 2.0-5.0g of sodium stearate, 16.0-27.0g of glycerol, 0.1-0.4g of tween-80, 0.02-0.10g of benzoic acid, 7.0-16.0g of bee wax, 0.1-0.7g of berberine, 0.8-3.0 ml of lithospermum soaked oil, 0.8-3.9g of chrysanthemum indicum extracted liquid and 1.0-4.0g of coconut oil. The gynecological pelvic inflammatory disease rectal suppository is light yellow in color, is moderate in hardness, is uniform in texture and is free of irritation. A weight difference and a melting time are in conformity with a requirement. The berberine, the lithospermum soaked oil and the chrysanthemum indicum extracted liquid and the like ingredients are good in antisepsis and anti-inflammation effect. The suppository is an effective drug for treating gynecological pelvic inflammatory disease and deserves to be further popularized and applicated.

Description

technical field [0001] The invention relates to an anal suppository for gynecological pelvic inflammatory disease and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease, pelvic inflammatory disease, is a relatively common gynecological disease. Pelvic inflammatory disease is divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease, which is a common and frequently-occurring disease that endangers women's physical and mental health. The disease has a low cure rate and a high recurrence rate. It has a great impact on women's life and work. If the treatment is not timely, it will bring serious complications, mental stress, infertility, ectopic pregnancy, tumor induction, etc., with endless troubles. [0003] At present, the treatment for pelvic inflammatory disease is mainly based on antibiotic anti-infection treatment. Hospital treatment is mainly divided into psychotherapy, drug treatment, physical therapy, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61K36/889A61P15/00A61P31/04A61K31/4375
Inventor 孙淑萍李胜利刘侠李子月丁婷孟祥奎
Owner 刘红枚
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